Protein structure in the truncated (2/2) hemoglobin family

IUBMB Life

Volumn 59, Issue 8-9, 2007, Pages 535-541

  Pesce, Alessandra ^a   Nardini, Marco ^b   Milani, Mario ^b   Bolognesi, Martino ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Globin fold; Heme ligand recognition; Hemoglobin; Hemoglobin evolution; Truncated hemoglobin

Indexed keywords

HEMOGLOBIN; TRYPTOPHAN; TYROSINE;

ALPHA HELIX; AMINO ACID SEQUENCE; HYDROGEN BOND; INVERTEBRATE; NONHUMAN; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE; REVIEW; VERTEBRATE; X RAY CRYSTALLOGRAPHY;

HEMOGLOBINS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEINS;

INVERTEBRATA; VERTEBRATA;

EID: 34547943491     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1080/15216540701225933     Document Type: Review

References (44)

1. Wittenberg, J. B., Bolognesi, M., Wittenberg, B. A., and Guertin, M. (2002) Truncated hemoglobins: a new family of hemoglobins widely distributed in bacteria, unicellular eukaryotes, and plants. J. Biol. Chem. 277, 871-874.
2. Vuletich, D. A., and Lecomte, J. T. (2006) A phylogenetic and structural analysis of truncated hemoglobins. J. Mol. Evol. 62, 196-210.
3. Hill, D. R., Belbin, T. J., Thorsteinsson, M. V., Bassam, D., Brass, S., Ernst, A., Boger, P., Paerl, H., Mulligan, M. E., and Potts, M. (1996) GlbN (cyanoglobin) is a peripheral membrane protein that is restricted to certain Nostoc spp. J. Bacteriol. 178, 6587-6598.
4. Ouellet, H., Ouellet, Y., Richard, C., Labarre, M., Wittenberg, B., Wittenberg, J., and Guertin, M. (2002) Truncated hemoglobin HbN protects Mycobacterium bovis from nitric oxide. Proc. Natl. Acad. Sci. USA 99, 5902-5907.
5. Pathania, R., Navani, N. K., Gardner, A. M., Gardner, P. R., and Dikshit, K. L. (2002) Nitric oxide scavenging and detoxification by the Mycobacterium tuberculosis haemoglobin, HbN in Escherichia coli. Mol. Microbiol. 45, 1303-1314.
6. Wainwright, L. M., Elvers, K. T., Park, S. F., and Poole, R. K. (2005) A truncated haemoglobin implicated in oxygen metabolism by microaerophilic food-borne pathogen Campylobacter jejuni. Microbiology 151, 4079-4091.
7. Wainwright, L. M., Wang, Y., Park, S. F., Yeh, S. R., and Poole, R. K. (2006) Purification and spectroscopic characterization of Ctb, a group III truncated hemoglobin implicated in oxygen metabolism in the food-borne pathogen Campylobacter jejuni. Biochemistry 45, 6003-6011.
8. Pesce, A., Couture, M., Dewilde, S., Guertin, M., Yamauchi, K., Ascenzi, P., Moens, L., and Bolognesi, M. (2000) A novel two-over-two α-helical sandwich fold is characteristic of the truncated hemoglobin family. EMBO J. 19, 2424-2434.
9. 2 diffusion to the heme. EMBO J. 20, 3902-3909.
10. Falzone, C. J., Vu, B. C., Scott, N. L., and Lecomte, J. T. (2002) The solution structure of the recombinant hemoglobin from the cyanobacterium Synechocystis sp. PCC 6803 in its hemichrome state. J. Mol. Biol. 324, 1015-1029.
11. Hoy, J. A., Kundu, S., Trent, J. T. 3rd, Ramaswamy, S., and Hargrove, M. S. (2004) The crystal structure of Synechocystis hemoglobin with a covalent heme linkage. J. Biol. Chem. 279, 16535-16542.
12. Trent, J. T. 3rd., Kundu, S., Hoy, J. A., and Hargrove, M. S. (2004) Crystallographic analysis of synechocystis cyanoglobin reveals the structural changes accompanying ligand binding in a hexacoordinate hemoglobin. J. Mol. Biol. 341, 1097-1108.
13. Milani, M., Savard, P. Y., Ouellet, H., Ascenzi, P., Guertin, M., and Bolognesi, M. (2003) A TyrCD1/TrpG8 hydrogen bond network and a TyrB10-TyrCD1 covalent link shape the heme distal site of Mycobacterium tuberculosis hemoglobin O. Proc. Natl. Acad. Sci. USA 100, 5766-5771.
14. Giangiacomo, L., Ilari, A., Boffi, A., Morea, V., and Chiancone, E. (2005) The truncated oxygen-avid hemoglobin from Bacillus subtilis: x-ray structure and ligand binding properties. J. Biol. Chem. 280, 9192-9202.
15. Bonamore, A., Ilari, A., Giangiacomo, L., Bellelli, A., Morea, V., and Boffi, A. (2005) A novel thermostable hemoglobin from the actinobacterium Thermobifida fusca. FEBS J. 272, 4189-4201.
16. Ilari, A., Kjelgaard, P., von Wachenfeldt, C., Catacchio, B., Chiancone, E., and Boffi, A. (2007) Crystal structure and ligand binding properties of the truncated hemoglobin from Geobacillus stearothermophilus. Arch. Biochem. Biophys. 457, 85-94.
17. Nardini, M., Pesce, A., Labarre, M., Richard, C., Bolli, A., Ascenzi, P., Guertin, M., and Bolognesi, M. (2006) Structural determinants in the group III truncated hemoglobin from Campylobacter jejuni. J. Biol. Chem. 281, 37803-37812.
18. Perutz, M. F. (1979) Regulation of oxygen affinity of hemoglobin: influence of structure of the globin on the heme iron. Annu. Rev. Biochem. 48, 327-386.
19. Kraulis, P. J. (1991). MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24, 946-950.
20. Nardini, M., Pesce, A., Milani, M., and Bolognesi, M. (2007) Protein fold and structure in the truncated (2/2) globin family. Gene in press.
21. Couture, M., Das, T. K., Savard, P. Y., Ouellet, Y., Wittenberg, J. B., Wittenberg, B. A., Rousseau, D. L., and Guertin, M. (2000) Structural investigations of the hemoglobin of the cyanobacterium Synechocystis PCC6803 reveal a unique distal heme pocket. Eur. J. Biochem. 267, 4770-4780.
22. Scott, N. L., Falzone, C. J., Vuletich, D. A., Zhao, J., Bryant, D. A., and Lecomte, J. T. (2002) Truncated hemoglobin from the cyanobacterium Synechococcus sp. PCC 7002: evidence for hexacoordination and covalent adduct formation in the ferric recombinant protein. Biochemistry 41, 6902-6910.
23. Milani, M., Pesce, A., Nardini, M., Ouellet, H., Ouellet, Y., Dewilde, S., Bocedi, A., Ascenzi, P., Guertin, M., Moens, L., Friedman, J. M., Wittenberg, J. B., and Bolognesi, M. (2005) Structural bases for heme binding and diatomic ligand recognition in truncated hemoglobins. J. Inorg. Biochem. 99, 97-109.
24. Couture, M., Yeh, S. R., Wittenberg, B. A., Wittenberg, J. B., Ouellet, Y., Rousseau, D. L., and Guertin, M. (1999) A cooperative oxygen-binding hemoglobin from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. USA 96, 11223-11228.
25. 2 stretching modes in oxyhemoglobins. Proc. Natl. Acad. Sci. USA 98, 479-484.
26. Yeh, S. R., Couture, M., Ouellet, Y., Guertin, M., and Rousseau, D. L. (2000) A cooperative oxygen binding hemoglobin from Mycobacterium tuberculosis. Stabilization of heme ligands by a distal tyrosine residue. J. Biol. Chem. 275, 1679-1684.
27. Samuni, U., Ouellet, Y., Guertin, M., Friedman, J. M., and Yeh, S. R. (2004) The absence of proximal strain in the truncated hemoglobins from Mycobacterium tuberculosis. J. Am. Chem. Soc. 126, 2682-2683.
28. Bolognesi, M., Bordo, D., Rizzi, M., Tarricone, C., and Ascenzi, P. (1997) Nonvertebrate hemoglobins: structural bases for reactivity. Prog. Biophys. Mol. Biol. 68, 29-68.
29. Hiner, A. N., Raven, E. L., Thorneley, R. N., Garcia-Canovas, F., and Rodriguez-Lopez, J. N. (2002) Mechanisms of compound I formation in heme peroxidases. J. Inorg. Biochem. 91, 27-34.
30. Samuni, U., Dankster, D., Ray, A., Wittenberg, J. B., Wittenberg, B. A., Dewilde, S., Moens, L., Ouellet, Y., Guertin, M., and Friedman, J. (2003) Kinetics modulation in the carbonmonoxy derivatives of truncated hemoglobins. The role of distal heme pocket residues and extended apolar tunnel. J. Biol. Chem. 278, 27241-27250.
31. Milani, M., Ouellet, Y., Ouellet, H., Guertin, M., Boffi, A., Antonini, G., Bocedi, A., Mattu, M., Bolognesi, M., and Ascenzi, P. (2004) Cyanide binding to truncated hemoglobins: a crystallographic and kinetic study. Biochemistry 43, 5213-5221.
32. Lecomte, J. T., Scott, N. L., Vu, B. C., and Falzone, C. J. (2001) Binding of ferric heme by the recombinant globin from the cyanobacterium Synechocystis sp. PCC 6803. Biochemistry 40, 6541-6552.
33. Vu, B. C., Nothnagel, H. J., Vuletich, D. A., Falzone, C. J., and Lecomte, J. T. (2004) Cyanide binding to hexacoordinate cyanobacterial hemoglobins: hydrogen-bonding network and heme pocket rearrangement in ferric H117A Synechocystis hemoglobin. Biochemistry 43, 12622-12633.
34. Couture, M., and Guertin, M. (1996) Purification and spectroscopic characterization of a recombinant chloroplastic haemoglobin from the green alga Chlamydomonas eugametos. Eur. J. Biochem. 242, 779-787.
35. Visca, P., Fabozzi, G., Petrucca, A., Ciaccio, C., Coletta, M., De Sanctis, G., Bolognesi, M., Milani, M., and Ascenzi, P. (2002) The truncated hemoglobin from Mycobacterium leprae. Biochem. Biophys. Res. Commun. 294, 1064-1070.
36. Ouellet, H., Juszczak, L., Dantsker, D., Samuni, U., Ouellet, Y. H., Savard, P. Y., Wittenberg, J. B., Wittenberg, B. A., Friedman, J. M., and Guertin, M. (2003) Reactions of Mycobacterium tuberculosis truncated hemoglobin O with ligands reveal a novel ligand-inclusive hydrogen bond network. Biochemistry 42, 5764-5774.
37. Bolognesi, M., Rosano, C., Losso, R., Borassi, A., Rizzi, M., Wittenberg, J. B., Boffi, A., and Ascenzi, P. (1999) Cyanide binding to Lucina pectinata hemoglobin I and to sperm whale myoglobin: an X-ray crystallographic study. Biophys. J. 77, 1093-1099.
38. Ascenzi, P., Bocedi, A., de Sanctis, D., Pesce, A., Bolognesi, M., Marden, M.C., Dewilde, S., Moens, L., Hankeln, T., and Burmester, T., (2004) Neuroglobin and cytoglobin: two new entries in the hemoglobin superfamily. Biochem. Mol. Biol. Educ. 32, 305-313.
39. Hankeln, T., Ebner, B., Fuchs, C., Gerlach, F., Haberkamp, M., Laufs, T. L., Roesner, A., Schmidt, M., Weich, B., Wystub, S., Saaler-Reinhardt, S., Reuss, S., Bolognesi, M., de Sanctis, D., Marden, M. C., Kiger, L., Moens, L., Dewilde, S., Nevo, E., Avivi, A., Weber, R. E., Fago, A., and Burmester, T. (2005) Neuroglobin and cytoglobin in search of their role in the vertebrate globin family. J. Inorg. Biochem. 99, 110-119.
40. Pesce, A., Bolognesi, M., Bocedi, A., Ascenzi, P., Dewilde, S., Moens, L., Hankeln, T., and Burmester, T. (2002) Neuroglobin and cytoglobin. Fresh blood for the vertebrate globin family. EMBO Rep. 3, 1146-1151.
41. de Sanctis, D., Dewilde, S., Pesce, A., Moens, L., Ascenzi, P., Hankeln, T., Burmester, T., and Bolognesi, M. (2004) Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination. J. Mol. Biol. 336, 917-927.
42. Ermler, U., Siddiqui, R. A., Cramm, R., and Friedrich, B. (1995) Crystal structure of the flavohemoglobin from Alcaligenes eutrophus at 1.75 Å resolution. EMBO J. 14, 6067-6077.
43. Freitas, T. A., Hou, S., and Alam, M. (2003) The diversity of globin coupled sensors. FEBS Lett. 552, 99-104.
44. Bonamore, A., Attili, A., Arenghi, F., Catacchio, B., Chiancone, E., Morea, V., and Boffi, A. (2007) A novel chimera: the "truncated hemoglobin-antibiotic monooxygenase" from Streptomyces avermitilis. Gene in press.