Cytogenetic aberrations and immunoglobulin VH gene mutations in clinically benign CD5- monoclonal B-cell lymphocytosis

American Journal of Clinical Pathology

Volumn 128, Issue 2, 2007, Pages 333-338

  Amato, Dominick ^a,c   Oscier, David G ^b   Davis, Zadie ^b   Mould, Sarah ^b   Zheng, Jianing ^a,c   Kolomietz, Elena ^a,c   Wang, Chen ^a,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b ROYAL BOURNEMOUTH HOSPITAL   (United Kingdom)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Benign lymphocytosis; CD5 ; Cytogenetics; IgVH mutations

Indexed keywords

CD5 ANTIGEN; IMMUNOGLOBULIN HEAVY CHAIN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; B CELL LYMPHOMA; B LYMPHOCYTE; CHROMOSOME 17Q; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOPHENOTYPING; LYMPHOCYTOSIS; MALE; PHENOTYPE; PRIORITY JOURNAL; SOMATIC MUTATION;

AGED; AGED, 80 AND OVER; ANTIGENS, CD5; B-LYMPHOCYTES; CHROMOSOME ABERRATIONS; FEMALE; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LYMPHOCYTOSIS; MALE; MIDDLE AGED; MUTATION;

EID: 34547906497     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/WB56ET6AGM44TM5T     Document Type: Article

References (19)

1. Marti GE, Rawstron AC, Ghia P, et al, for the International Familial CLL Consortium. Diagnostic criteria for monoclonal B-cell lymphocytosis. Br J Haematol. 2005;130:325-332.
2. Ghia P, Prato G, Scielzo C, et al. Monoclonal CD5+ and CD5- B lymphocyte expansions are frequent in the peripheral blood of the elderly. Blood. 2004;103:2337-2342.
3. Rawstron AC, Green MJ, Kuzmicki A, et al. Monoclonal B lymphocytosis with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts. Blood. 2002;100:635-639.
4. O'Connor SJM, Rawstron AC, Plummer M, et al. Demonstration of the genotypic relationship between CLUS and clinical B-CLL [abstract]. Leuk Lymphoma. 2003;44(suppl 2):S13.
5. Wang C, Amato D, Fernandes F. CD5-negative phenotype of monoclonal B-lymphocytosis of undetermined significance (MLUS). Am J Hematol. 2002;69:147-149.
6. Wang C, Amato D, Rabah R, et al. Differentiation of monoclonal B lymphocytosis of undetermined significance (MLUS) and chronic lymphocytic leukemia (CLL) with weak CD5 expression from CD5- CLL. Leuk Res. 2002;26:1125-1129.
7. H gene repertoire: differential effects of selection and somatic hypermutation on human CD5+/IgM and CD5-/IgM B cells. J Clin Invest. 1997;99:2488-2501.
8. H genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848-1854.
9. Oscier DG, Gardiner A, Mould S. Structural abnormalities of chromosome 7q in chronic lymphoproliferative disorders. Cancer Genet Cytogenet. 1996;92:24-27.
10. Sole F, Woessner S, Soledad F, et al. Frequent involvement of chromosomes 1, 3, 7 and 8 in splenic marginal zone B-cell lymphoma. Br J Haematol. 1997;98:446-449.
11. Corcoran MM, Mould SJ, Orchard JA, et al. Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations. Oncogene. 1999;18:6271-6277.
12. LeMaoult J, Szabo P, Weksler ME. Effect of age on humoral immunity selection of the B-cell repertoire and B-cell development. Immunol Rev. 1997;160:115-126.
13. Han T, Ozer H, Gavigan M, et al. Benign monoclonal B cell lymphocytosis: a benign variant of CLL: clinical, immunologic, phenotypic and cytogenetic studies in 20 patients. Blood. 1984;64:244-252.
14. Garcia C, Rosen A, Kimby E, et al. Higher T-cell imbalance and growth factor receptor expression in B-cell chronic lymphocytic leukemia as compared to monoclonal B-cell lymphocytosis of undetermined significance (B-MLUS). Leuk Res. 1989;13:31-37.
15. Kimby E, Mellstedt H, Nilsson B, et al. Differences in blood T and NK cell populations between chronic lymphocytic leukemia of B cell type and monoclonal B-lymphocytosis of undetermined significance (B-MLUS). Leukemia. 1989;3:501-504.
16. Byrd J. Clonal lymphocytosis of uncertain significance (CLUS): what clues will CLUS yield? Blood. 2002;100:2277.
17. Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute-sponsored working group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996;87:4990-4997.
18. Chiorazzi N, Rai KR, Ferrarini M. Chronic lymphocytic leukemia. N Engl J Med. 2005;352:804-815.
19. Dohner H, Stilgenbauer S, Benner A, et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med. 2000;343:1910-1916.