Role of the appendix in the pathogenesis of ulcerative colitis

Inflammopharmacology

Volumn 15, Issue 4, 2007, Pages 154-157

  Matsushita, M ^a   Uchida, K ^a   Okazaki, K ^a  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

Author keywords

Activated T cell; Appendectomy; Appendix; CD4+ T cell; Ulcerative colitis

Indexed keywords

HLA DR ANTIGEN;

APPENDECTOMY; APPENDIX; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; HISTOPATHOLOGY; HUMAN; IMMUNE RESPONSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE ACTIVATION; ULCERATIVE COLITIS;

ANIMALS; APPENDECTOMY; APPENDIX; CD4-CD8 RATIO; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; COLITIS, ULCERATIVE; HUMANS;

EID: 34547873532     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-007-1563-7     Document Type: Review

References (33)

1. Andersson, R. E. et al. (2001) Appendectomy and protection against ulcerative colitis, N. Engl. J. Med. 344, 808-814.
2. Bhan, A. K. et al. (1999) Colitis in transgenic and knockout animals as models of human inflammatory bowel disease, Immunol. Rev. 169, 195-207.
3. Bitton, A. et al. (2001) Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis, Gastroenterology 120, 13-20.
4. Cosnes, J. et al. (2002) Effects of appendicectomy on the course of ulcerative colitis, Gut 51, 803-807.
5. Eri, R.D. et al. (2002) Appendectomy for refractory ulcerative colitis: targeting the right patient, Gastroenterology 122, A61.
6. Fiocchi, C. (1998) Inflammatory bowel disease: etiology and pathogenesis, Gastroenterology 115, 182-205.
7. Hallas, J. et al. (2004) Appendicectomy has no beneficial effect on admission rates in patients with ulcerative colitis, Gut 53, 351-354.
8. Hallas, J. et al. (2004) The role of age in the protection of appendicectomy against ulcerative colitis: author's reply, Gut 53, 1719-1720.
9. Hu, D. et al. (2004) Analysis of regulatory CD8 T cells in Qa-1-deficient mice, Nat. Med. 5, 516-523.
10. Järnerot, G. et al. (2001) Laparoscopic appendectomy in patients with refractory ulcerative colitis, Gastroenterology 120, 1562-1563.
11. Jo, Y. et al. (2003) Histological and immunological features of appendix in patients with ulcerative colitis, Dig. Dis. Sci. 48, 99-108.
12. Kroft, S.H. et al. (1994) Appendiceal involvement as a skip lesion in ulcerative colitis, Mod. Pathol. 7, 912-914.
13. Matsumoto, T. et al. (2002) Significance of appendiceal involvement in patients with ulcerative colitis, Gastrointest. Endosc. 55, 180-185.
14. Matsushita, M. et al. (2005) Appendix is a priming site in the development of ulcerative colitis, World J. Gastroenterol. 11, 4869-4874.
15. Mizoguchi, A. et al. (1996) Role of appendix in the development of inflammatory bowel disease in TCR-a mutant mice, J. Exp. Med. 184, 707-715.
16. Mizoguchi, A. et al. (2000) Limited CD4 T-cell diversity associated with colitis in T-cell receptor a mutant mice requires a T helper 2 environment, Gastroenterology 119, 983-995.
17. Müller, S. et al. (1998) Activated CD4+ and CD8+ cytotoxic cells are present in increased numbers in the intestinal mucosa from patients with active inflammatory bowel disease, Am. J. Pathol. 152, 261-268.
18. Naganuma, M. et al. (2001) Appendectomy protects against the development of ulcerative colitis and reduces its recurrence: results of a multicenter case-controlled study in Japan, Am. J. Gastroenterol. 96, 1123-1126.
19. Okazaki, K. et al. (2000) A patient with improvement of ulcerative colitis after appendectomy, Gastroenterology 119, 502-506.
20. Panaccione, R., Sandborn, W.J. (1999) The appendix in ulcerative colitis: a not so innocent bystander, Gastroenterology 117, 272-273.
21. Probert, C. S. et al. (1996) Persistent clonal expansions of peripheral blood CD4+ lymphocytes in chronic inflammatory bowel disease, J. Immunol. 157, 3183-3191.
22. Rachmilewitz, D. et al. (2002) Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis, Gastroenterology 122, 1428-1441.
23. Radford-Smith, G. L. et al. (2002) Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn's disease, Gut 51, 808-813.
24. Russel, M. G. et al. (1997) Appendectomy and the risk of developing ulcerative colitis or Crohn's disease: results of a large case-control study, Gastroenterology 113, 377-382.
25. Rutgeerts, P. et al. (1994) Appendectomy protects against ulcerative colitis, Gastroenterology 106, 1251-1253.
26. Scott, I. S. et al. (1998) Appendiceal inflammation in ulcerative colitis, Histopathology 33, 168-173.
27. Selby, W. S. et al. (2002) Appendectomy protects against the development of ulcerative colitis but not affect its course, Am. J. Gastroenterol. 97, 2834-2838.
28. Simpson, S. J. et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-dificient colitis, Eur. J. Immunol. 25, 2618-2625.
29. Takahashi, I. et al. (1997) CD4+ T-cell population mediates development of inflammatory bowel disease in T-cell receptor a chain-deficient mice, Gastroenterology 112, 1876-1886.
30. Taurog, J. D. et al. (1994) The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats, J. Exp. Med. 180, 2359-2364.
31. Tibble, J. A. et al. (2000) Surrogate marker of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease, Gastroenterology 119, 15-22.
32. Ueyama, H. et al. (1998) High Fas ligand expression on lymphocytes in lesions of ulcerative colitis, Gut 43, 48-55.
33. Walker, M. R. et al. (2003) Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25- T cells, J. Clin. Invest. 112, 1437-1443.