Stem cell factor functions as a survival factor for mature Leydig cells and a growth factor for precursor Leydig cells after ethylene dimethane sulfonate treatment: Implication of a role of the stem cell factor/c-kit system in Leydig cell development

Developmental Biology

Volumn 227, Issue 1, 2000, Pages 169-182

  Yan, Wei ^a,b   Kero, Jukka ^a,b   Huhtaniemi, Ilpo ^a   Toppari, Jorma ^a,b  

^a Department of Physiology ^*  (Finland)

^b UNIVERSITY OF TURKU   (Finland)

Author keywords

C kit; Leydig cell; Stem cell factor; Testis; Testosterone

Indexed keywords

ETHYLENE GLYCOL DIMESYLATE; GONADOTROPIN; GROWTH FACTOR; STEM CELL FACTOR; STEM CELL FACTOR RECEPTOR; TESTOSTERONE;

ADOLESCENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; LEYDIG CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STEM CELL; TESTIS DEVELOPMENT; TESTOSTERONE SYNTHESIS;

ANIMALIA;

EID: 0034331256     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.9885     Document Type: Article

References (42)

1. Gene expression of luteinizing hormone receptor and steroidogenic enzymes during Leydig cell development
2. Exogenous stem cell factor (SCF) compensates for altered SCF expression in 2,5-hexanedione-induced testicular atrophy
3. Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms
4. Leuprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2,5-hexanedione-induced irreversible testicular injury in the rat, resulting in normalized stem cell factor expression
5. Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility
6. The primary structure of rat ribosomal protein L19. A determination from the sequence of nucleotides in a cDNA and from the sequence of amino acids in the protein
7. Expression of c-kit receptor and its autophosphorylation in immature rat type A spermatogonia
8. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing a Sld mutant
9. The kit ligand, stem cell factor
10. A supersensitive immunofluorometric assay for rat luteinizing hormone
11. Function of stem cell factor as a survival factor of spermatogonia and localization of messenger ribonucleic acid in the rat seminiferous epithelium
12. Inhibin, activin, and follistatin in reproductive medicine
13. Testosterone inhibits and induces apoptosis in rat seminiferous tubules in a stage-specific manner: In situ quantification in squash preparations after administration of ethane dimethane sulfonate
14. Differential expression and processing of two cell-associated forms of the kit-ligand: KL-1 and KL-2
15. Treatment of prostatic cancer with a gonadotropin-releasing hormone agonist analog: Acute and long term effects on endocrine functions of testis tissue
16. Comparative protective actions of gonadotrophins and testosterone against the antispermatogenic action of ethane dimethanesulphonate
17. Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses
18. Sexual maturation of male rats treated postnatally with a gonadotropin-releasing hormone
19. Purification and characterization of soluble forms of human and rat stem cell factor recombinantly expressed by Escherichia coli and by Chinese hamster ovary cells
20. Stem cell factor and c-kit in the mammalian testis: Lessons originating from Mother Nature's gene knockouts
21. Primary structure and functional expression of rat and human stem cell factor DNAs
22. Ethylene dimethanesulphonate destroys Leydig cells in the rat testis
23. Influence of rat seminiferous tubules on LC testosterone production in vitro
24. Gonadal regulation of hypothalamic gonadotropin-releasing hormone release in primates
25. Expression of the mRNA for the ligand of c-kit in mouse Sertoli cells
26. Follicle-stimulating hormone induction of steel factor (SLF) mRNA in mouse Sertoli cells and stimulation of DNA synthesis in spermatogonia by soluble SLF
27. Expression of c-kit and its ligand, stem cell factor, in normal and subfertile human testicular tissue
28. Developmental changes in levels of luteinizing hormone receptor and androgen receptor in rat Leydig cells
29. Consequences of exclusive expression in vivo of Kit-ligand lacking the major proteolytic cleavage site
30. Biologically active kit ligand growth factor is produced by mouse Sertoli cells and is defective in Sld mutant mice
31. Hormonal control of apoptotic cell death in the testis: Gonadotropins and androgens as testicular cell survival factors
32. LC apoptosis in the rat testes after administration of the cytotoxin ethane dimethanesulphonate: Role of the Bcl-2 family members
33. Human stem cell factor promoter deoxyribonucleic acid sequence and the regulation by cyclic 3',5'-adenosine monophosphate in a Sertoli cell line
34. Regeneration of Leydig cells after depletion by EDS: A model for postnatal Leydig cell renewal
35. Identification of markers for precursor and LC differentiation in the adult rat testis following ethane dimethyl sulphonate administration
36. The regulation of the proliferation and differentiation of rat LC precursor cells after EDS administration or daily HCG treatment
37. Molecular mechanisms of reappearance of luteinizing hormone receptor expression and function in rat testis after selective LC destruction by ethylene dimethane sulfonate
38. The pattern of inhibin/activin α- and β(B)-subunit messenger ribonucleic acid expression in the rat testis after selective Leydig cell destruction by ethylene dimethane sulfonate
39. Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse: A kit-kl interaction critical for meiosis
40. Stage-specific regulation of stem cell factor gene expression in the rat seminiferous epithelium
41. Stem cell factor protects germ cells from apoptosis in vitro
42. Role of c-kit in mouse spermatogenesis: Identification of spermatogonia as a specific site of c-kit expression and function