Leuprolide, a gonadotropin-releasing hormone agonist, reestablishes spermatogenesis after 2, 5-hexanedione-induced irreversible testicular injury in the rat, resulting in normalized stem cell factor expression

Endocrinology

Volumn 139, Issue 1, 1998, Pages 236-244

  Blanchard, Kerry T ^a   Lee, Jeongwu ^b   Boekelheide, Kim ^b  

^a BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^b BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85011500653     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/endo.139.1.5678     Document Type: Article

References (50)

1. ZirkinBR1993Regulation of spermatogenesis in the adult mammal: gonadotropins and androgens. In: Desjardins CD, Ewing LL (eds) Cell and Molecular Biology of the Testis. Oxford University Press, New York, pp 166-188
2. RussellLD1993Role in spermiation.In: Russell LD, Griswold MD (eds) The Sertoli cell. Cache River Press, Clearwater, FL, pp 269-303
3. de KresterDM1994Clinical male infertility. I. Prevalence of and progress in understanding male infertility. Reprod Fertil Dev6:3-8
4. Howards SS 1995 Current concepts: treatment of male infertility. N Engl J Med 332:312-317
5. Sherins RJ 1995 Are semen quality and male infertility changing? N Engl J Med 332:327
6. CarlsenE, GiwercmanA, KeidingN, SkakkebaekNE1992Evidence for decreasing quality of semen during past 50 years. Br J Med305:609-613
7. AugerJ, KunstmannJM, CzyglikF, Jouanet, P 1995 Decline in semen quality among fertile men in Paris during the past 20 years. N Engl J Med332:281-285
8. GiwercmanA, CarlsenE, KeidingN, SkakkebaekNE1993Evidence for increasing incidence of abnormalities of the human testis: a review. Environ Health Perspect101[Suppl 2]:65-71
9. RichburgJH, BlanchardKT, BoekelheideK1997The Sertoli cell as a target for toxicants.In: Sipes IG, McQueen CA, Gandolfi AJ (eds) Comprehensive toxicology, vol 10: Reproductive and endocrine toxicology, sect I: Male reproductivetoxciology. Elsevier Science, Oxford, pp 127-138
10. Chapin RE, Morgan KT, Bus JS 1983 The morphogenesis of testicular degeneration induced in rats by orally administered 2, 5-hexanedione. Exp Mol Pathol 38:149-169
11. BoekelheideK1988Rat testis during 2, 5-hexanedione intoxication and recovery. I. Dose response and the reversibility of germ cell loss. Toxicol Appl Pharmacol92:18-27
12. KrasavageWJ, O'DonoghueJL, DiVincenzoGD, TerhaarCJ1980The relative neurotoxicity of methyl-w-butyl-ketone, «-hexane, and their metabolites. Toxicol Appl Pharmacol52:433-441
13. PerbelliniL, BrugnoneF, PavanI1980Identification of the metabolites of β-hexane, cyclohexane, and their isomers in men's urine.Toxicol Appl Pharmacol53:220-229
14. O'DonoghueJL, KrasavageWJ, TerhaarCJ1978Toxic effects of 2, 5-hexanedione. Toxicol Appl Pharmacol45:269
15. JohnsonKJ, HallES, Boekelheide K 1991 2, 5-Hexanedione exposure alters the rat Sertoli cell cytoskeleton. I. Microtubules and seminiferous tubule fluid secretion. Toxicol Appl Pharmacol111:432-442
16. RichburgJH, RedenbachDM, Boekelheide K 1994 Seminiferous tubule fluid secretion is a Sertoli cell microtubule-dependent process inhibited by 2, 5-hexanedione exposure. Toxicol Appl Pharmacol128:302-309
17. BoekelheideK, Hall SJ 1991 2, 5-Hexanedione exposure in the rat results in long-term testicular atrophy despite the presence of residual spermatogonia. J Androl12:18-26
18. AllardEK, Boekelheide K 1996 Fate of germ cells in 2, 5-hexanedione-induced testicular injury. II. Atrophy persists due to a reduced stem cell mass and ongoing apoptosis. Toxicol Appl Pharmacol137:149-156
19. AllardEK, HallSJ, BoekelheideK1995Stem cell kinetics in rat testis after irreversible injury induced by 2, 5-hexanedione. Biol Reprod53:186-192
20. GalliSJ, ZseboKM, GeisslerEN1994The kit ligand, stem cell factor. Adv Immunol55:1-94
21. YoshinagaK, NishikawaS, OgawaM, HayashiS, KunidadaT, FujimotoT, NishikawaS1991Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function. Development113:689-699
22. AllardEK, BlanchardKT, BoekelheideK1996Exogenous stem cell factor (SCF) compensates for altered endogenous SCF expression in 2, 5-hexanedione-induced testicular atrophy. Biol Reprod55:185-193
23. ManovaK, HuangEJ, AngelesM, LeonVD, SanchezS, PronovostSM, BesmerP, BachvarovaRF1993The expression pattern of the c-kit ligand in gonads of mice supports a role for the c-kit receptor in oocyte growth and in proliferation of spermatogonia. Dev Biol157:85-99
24. FlanaganJ, ChenD, LederP1991Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in Sid mutant. Cell64:1025-1035
25. TajimaY, OnoueH, KitamuraY, NishimuneY1991Biologically active kit ligand growth factor is produced by mouse Sertoli cells and is defective in Sid mutant mice. Development113:1031-1035
26. AndersonDM, LymanSD, BairdA, WignallJM, EisenmanJ, RauchC, MarchCJ, BoswellHS, GimpelSD, CosmanD, Williams DE1990 Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms. Cell63:235-243
27. LangleyKE, MendiazEA, LiuN, NarhiLO, ZeniL, ParseghianCM, ClogstonCL, LeslieI, PopeJA, LuHS, ZseboKM, Boone TC1994 Properties of variant forms of human stem cell factor recombinantly expressed in Escherichia coli. Arch Biochem Biophy311:55-61
28. BrannanCJ, BedellMA, ResnickJL, EppigJJ, HandelMA, WilliamsKE, LymanSD, DonovanPJ, JenkinsNA, CopelandNG1992Developmental abnormalities in Steel 17H mice results from a splicing defect in the steel factor cytoplasmic tail. Genes Dev6:1832-1842
29. MarzialiG, LazzaroD, Sorrentino V 1993 Binding of germ cells to mutant Sid Sertoli cells is defective and is rescued by expression of the transmembrane form of the c-kit ligand. Dev Biol157:182-190
30. DolciS, WilliamsDE, ErnstMK, ResnickJL, Brannan CI, LockLF, LymanSD, BoswellHS, DonovanPJ1991Requirement for mast cell growth factor for primordial germ cell survival in culture. Nature352:809-811
31. MeistrichML, ParchuriN, WilsonG, JurdogluB, KangasniemiM1995Hormonal protection from cyclophosphamide-induced inactivation of rat stem spermatogonia. J Androl16:334-341
32. KangasniemiM, WilsonG, ParchuriN, HuhtaniemiI, MeistrichML1995Rapid protection of rat spermatogenic stem cells against procarbazine by treatment with a gonadotropin-releasing hormone antagonist (Nal-Glu) and an antiandrogen (flutamide). Endocrinology136:2881-2888
33. KangasniemiM, WilsonG, HuhtaniemiI, MeistrichML1995Protection against procarbazine-induced testicular damage by GnRH-agonist and antiandrogen treatment in the rat. Endocrinology136:3677-3680
34. MeistrichML, KangasnemiM1997Hormone treatment after irradiation stimulates recovery of rat spermatogenesis from surviving spermatogonia. J Androl18:80-87
35. OkadaH, DokenY, OgawaY, ToguchiH1994Sustained suppression of the pituitary-gonadal axis by leuprorelin three-month depot microspheres in rats and dogs. Pharmacol Res11:1199-1203
36. HudsonPB, HakkySI, LombardoME1994Testicular androgens in prostate cancer patients treated with a luteinizing hormone releasing hormone agonist. J Urol151:1281-1282
37. Physicians' DeskReference 1997 51st ed. Medical Economics Co., Montvale, NJ, pp 2736-2741
38. ChapinRE, RossMD, LambJC1984Immersion fixation methods for glycol methacrylate-embedded testes. Toxicol Pathol12:221-227
39. RussellLD, EttlinRA, Sinha HikimAP, CleggED1990Histological and histopathological evaluation of the testis. Cache River Press, Clearwater, FL, pp 63-118
40. MartinFH, SuggsSV, LangleyKE, LuHS, TingJ, OkinoKH, MorrisCF, McNieceIK, JacobsenFW, MendiazEA, BirkettN, SmithK, JohnsonM, ParderV, FloresJ, PatelA, FisherE, ErjavecH, HerreraC, WypychJ, SachdevR, PopeJ, LeslieI, WenD, LinC-H, CupplesR, ZseboKM1990Primary structure and functional expression of rat and human stem cell factor DNAs. Cell63:203-211
41. OkadaH, HeyaT, IgariY, OgawaY, ToguchiH, ShimamotoT1989One-month release injectable microspheres of leuprolide acetate inhibit steroidogenesis and genital organ growth in rats. J Pharmaceut54:231-239
42. DiamondDA, FloresC, KumarS, MalhotraR, SeethalakshmiL1992The effects of an LHRH agonist on testicular function in the cryptorchid rat. J Urol147:264-269
43. SetchellBP, GalilKAA1983Limitations imposed by testicular blood flow on the function of Leydig cells in rats in vivo. Aust J Biol Sci36:285-293
44. MeistrichML, WilsonG, YeWS, ThrashC, HuhtaniemiI1996Relationship among hormonal treatments, suppression of spermatogenesis, and testicular protection from chemotherapy-induced damage. Endocrinology137:3823-3831
45. HsuehAJ W, Jones PBC1981 Extrapituitary actions of gonadotropin-releasing hormone. Endocr Rev2:437-461
46. ClaytonRN, KatikineniM, ChanV, DufauML, Catt KJ 1980 Direct inhibition of testicular function by gonadotropin-releasing hormone: mediation by specific gonadotropin-releasing hormone receptors in interstitial cells. Biochemistry77:4459-4463
47. ElkingtonJSH, SanbornBM, MartinMW, ChowdhuryAK, SteinbergerE1994Effect of testosterone propionate on ABP levels in rats hypophysecto-mized at different ages using individual sampling. Mol Cell Endocrinol6:203-209
48. TajimaY, NishinaY, KoshimizuU, JippoT, KitamuraY, Nishimune Y 1993 Effects of hormones, cyclic AMP analogues and growth factors on steel factor (SF) production in mouse Sertoli cell cultures. J Reprod Fertil99:571-575
49. TaylorWE, NajmabadiH, StratheamM, JouNT, LieblingM, RajavashisthT, ChanaiN, PhungL, BhasinS1996Human stem cell factor promoter deoxyribonucleic acid sequence and regulation by cyclic 3', 5'-adenosine monophosphate in a Sertoli cell line. Endocrinology137:5407-5414
50. McGuinnessMP, OrthJM1992Reinitiation of gonocyte mitosis and movement of gonocytes to the basement membrane in testes of newborn rats in vivo and in vitro. Anat Rec233:527-537