Cytotoxic small molecule dimers and their inhibitory activity against human breast cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 18, 2007, Pages 5063-5067

  Hadden, M Kyle ^a   Blagg, Brian S J ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Cytotoxic; Dimers; Inhibitors; Modulators

Indexed keywords

ANTINEOPLASTIC AGENT; ARTEMISININ DIMER; COUMAMYCIN A1; DICERANDROL A; DICERANDROL B; DICERANDROL C; DIMER; ESTROGEN RECEPTOR; TORREYANIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DIMERIZATION; HUMANS;

EID: 34547855099     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.07.014     Document Type: Article

References (22)

1. Schlessinger J. Cell 103 (2000) 211
2. Wiesmann C., Fuh G., Christinger H.W., Eigenbrot C., Wells J.A., and de Vos A.M. Cell 91 (1997) 695
3. Kossiakoff A.A., and de Vos A.M. Adv. Protein Chem. 52 (1998) 67
4. Jiang G., and Hunter T. Curr. Biol. 9 (1999) R568
5. Hall J.M., Couse J.F., and Korach K.S. J. Biol. Chem. 276 (2001) 36869
6. Tamrazi A., Carlson K.E., Daniels J.R., Hurth K.M., and Katzenellenbogen J.A. Mol. Endocrin. 16 (2002) 2706
7. Brandt M.E., and Vickery L.E. J. Biol. Chem. 272 (1997) 4843
8. Blagg B.S.J., and Kerr T.D. Med. Res. Rev. 26 (2006) 310
9. Lee J.C., Strobel G.A., Lobovsky E., and Clardy J. J. Org. Chem. 61 (1996) 3232
10. Wagenaar M.M., and Clardy J. J. Nat. Prod. 64 (2001) 1006
11. Marcu M.G., Schulte T.W., and Neckers L. J. Natl. Can. Inst. 92 (2000) 242
12. Burlison J.A., and Blagg B.S.J. Org. Lett. 8 (2006) 4855
13. Posner G.H., Ploypradith P., Parker M.H., O'Dowd H., Woo S.-H., Northrop J., Krasavin M., Dolan P., Kensler T.W., Xie S., and Shapiro T.A. J. Med. Chem. 42 (1999) 4275
14. Posner G.H., McRiner A.J., Paik I.H., Sur S., Borstnik K., Xie S., Shapiro T.A., Alagabala A., and Foster B. J. Med. Chem. 47 (2004) 1299
15. Posner G.H., Paik I.H., Sur S., McRiner A.J., Borstnik K., Xie S., and Shapiro T.A. J. Med. Chem. 46 (2003) 1060
16. Jeyadevan J.P., Bray P.G., Chadwick J., Mercer A.E., Byrne A., Ward S.A., Park B.K., Williams D.P., Cosstick R., Davies J., Higson A.P., Irving E., Posner G.H., and O'Neill P.M. J. Med. Chem. 47 (2004) 1290
17. Zheng F.F., Kuduk S.D., Chiosis G., Munster P.N., Sepp-Lorenzino L., Danishefsky S.J., and Rosen N. Cancer Res. 60 (2000) 2090
18. Bergmann K.E., Wooge C.H., Carlson K.E., Katzenellenbogen B.S., and Katzenellenbogen J.A. J. Steroid Biochem. Mol. Biol. 49 (1994) 139
19. Groleau S., Nault J., Lepage M., Couture M., Dallaire N., Berube G., and Gaudreault R.C. Bioorg. Chem. 27 (1999) 383
20. 1H NMR (Yields 16-92%).
21. Galam L., Hadden M.K., Ma Z., Ye Q.-Z., Yun B.-G., Blagg B.S.J., and Matts R.L. Bioorg. Med. Chem. 15 (2007) 1939
22. Thornber C.W. Chem. Soc. Rev. 8 (1979) 563