Multiphase Contrast-Enhanced CT Imaging in Hepatocellular Carcinoma. Correlation With Immunohistochemical Angiogenic Activities

Academic Radiology

Volumn 14, Issue 9, 2007, Pages 1084-1091

  Kim, Young Il ^a   Chung, Jin Wook ^b   Park, Jae Hyung ^b   Kang, Gyeong Hoon ^b   Lee, Minjin ^c   Suh, Kyung Suk ^b   Kim, Kwang Gi ^b  

^a National Cancer Center   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Hallym University College of Medicine   (South Korea)

Author keywords

angiogenesis; computed tomography; Hepatocellular carcinoma

Indexed keywords

CD34 ANTIGEN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ADULT; AGED; ANGIOGENESIS; AORTA; ARTICLE; CANCER SURGERY; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; CORRELATION ANALYSIS; DIAGNOSTIC IMAGING; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIVER CELL CARCINOMA; LIVER PARENCHYMA; LIVER RESECTION; MALE; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; TUMOR BLOOD FLOW;

ADULT; AGED; BIOLOGICAL MARKERS; CARCINOMA, HEPATOCELLULAR; FEMALE; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; RADIOGRAPHIC IMAGE ENHANCEMENT; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; STATISTICS; TOMOGRAPHY, X-RAY COMPUTED; TUMOR MARKERS, BIOLOGICAL;

EID: 34547839732     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2007.06.015     Document Type: Article

References (38)

1. Liotta L.A., Steeg P.S., and Stetler-Stevenson W.G. Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 64 (1991) 327-336
2. Folkman J. Endothelial cells and angiogenic growth factors in cancer growth and metastasis. Cancer Metastasis Rev 9 (1990) 171-174
3. Marme D. Tumor angiogenesis: the pivotal role of vascular endothelial growth factor. World J Urol 14 (1996) 166-174
4. Takahashi Y., Kitadai Y., Bucana C.D., et al. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 55 (1995) 3964-3968
5. Miura H., Miyazaki T., Kuroda M., et al. Increased expression of vascular endothelial growth factor in human hepatocellular carcinoma. J Hepatol 27 (1997) 854-861
6. Ueda K., Terada T., Nakamura Y., et al. Vascular supply in adenomatous hyperplasia of the liver and hepatocellular carcinoma: a morphometric study. Hum Pathol 23 (1992) 619-626
7. Yamaguchi R., Yano H., Iemura A., et al. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 28 (1998) 68-77
8. Schlingemann R.O., Rietveld F.J., de-Waal R.M., et al. Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma. Lab Invest 62 (1990) 690-696
9. Anthony P.P., and Ramani P. Endothelial markers in malignant vascular tumors of the liver: superiority of QB-END/10 over von Willebrand factor and Ulex europaeus agglutinin 1. J Clin Pathol 44 (1991) 29-32
10. Ruck P., Xiao J.C., and Kaiserling E. Immunoreactivity of sinusoids in hepatocellular carcinoma: an immunohistochemical study using lectin UEA-1 and antibodies against endothelial markers, including CD34. Arch Pathol Lab Med 119 (1995) 173-178
11. Tanigawa N., Lu C., Mitsui T., et al. Quantitation of sinusoid-like vessels in hepatocellular carcinoma: its clinical and prognostic significance. Hepatology 26 (1997) 1216-1223
12. Weidner N. Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol 147 (1995) 9-19
13. Brasch R., and Turetschek K. MRI characterization of tumors and grading angiogenesis using macromolecular contrast media: status report. Eur J Radiol 34 (2000) 148-155
14. Kanematsu M., Osada S., Amaoka N., et al. Expression of vascular endothelial growth factor in hepatocellular carcinoma and the surrounding liver: correlation with angiographically assisted CT. AJR Am J Roentgenol 183 (2004) 1585-1593
15. Wang B., Gao Z.Q., and Yan X. Correlative study of angiogenesis and dynamic contrast-enhanced magnetic resonance imaging features of hepatocellular carcinoma. Acta Radiol 46 (2005) 353-358
16. Wang J.H., Min P.Q., Wang P.J., et al. Dynamic CT evaluation of tumor vascularity in renal cell carcinoma. AJR Am J Roentgenol 186 (2006) 1423-1430
17. Thompson W.D., Li W.W., and Maragoudakis M. The clinical manipulation of angiogenesis: pathology, side-effects, surprises and opportunities with novel human therapies. J Pathol 190 (2000) 330-337
18. Patt Y.Z., Hassan M.M., Lozano R.D., et al. Durable clinical response of refractory hepatocellular carcinoma to orally administered thalidomide. Am J Clin Oncol 23 (2000) 319-321
19. Gasparini G., Weidner N., Bevilacqua P., et al. Tumor microvessel density, p53 expression, tumor size, and peritumoral lymphatic vessel invasion are relevant prognostic markers in node-negative breast carcinoma. J Clin Oncol 12 (1994) 454-466
20. Cuenod C.A., Fournier L., Balvay D., et al. Tumor angiogenesis: pathophysiology and implications for contrast-enhanced MRI and CT assessment. Abdom Imaging 31 (2006) 188-193
21. Padhani A.R. Functional MRI for anticancer therapy assessment. Eur J Cancer 38 (2002) 2116-2127
22. Miles K.A. Functional computed tomography in oncology. Eur J Cancer 38 (2002) 2079-2084
23. Cuenod C., Leconte I., Siauve N., et al. Early changes in liver perfusion caused by occult metastases in rats: detection with quantitative CT. Radiology 218 (2001) 556-561
24. Poon R.T., Ng I.O., Lau C., et al. Tumor microvessel density as a predictor of recurrence after resection of hepatocellular carcinoma: a prospective study. J Clin Oncol 20 (2002) 1775-1785
25. Kwak B.K., Shim H.J., Park E.S., et al. Hepatocellular carcinoma: correlation between vascular endothelial growth factor level and degree of enhancement by multiphase contrast-enhanced computed tomography. Invest Radiol 36 (2001) 487-492
26. Jeng K.S., Sheen I.S., Wang Y.C., et al. Is the vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma of prognostic value after resection?. World J Gastroenterol 10 (2004) 676-681
27. Ng I.O., Poon R.T., Lee J.M., et al. Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma. Am J Clin Pathol 116 (2001) 838-845
28. Buckley D.L. Uncertainty in the analysis of tracer kinetics using dynamic contrast-enhanced T1-weighted MRI. Magn Reson Med 47 (2002) 601-606
29. Padhani A.R., and Neeman M. Challenges for imaging angiogenesis. Br J Radiol 74 (2001) 886-890
30. Anderson H., Price P., Blomley M., et al. Measuring changes in human tumour vasculature in response to therapy using functional imaging techniques. Br J Cancer 85 (2001) 1085-1093
31. Tajima T., Honda H., Taguchi K., et al. Sequential hemodynamic change in hepatocellular carcinoma and dysplastic nodules. AJR Am J Roentgenol 178 (2002) 885-897
32. Leggett D.A., Kelley B.B., Bunce I.H., et al. Colorectal cancer: diagnostic potential of CT measurements of hepatic perfusion and implications for contrast enhancement protocols. Radiology 205 (1997) 716-720
33. Fournier L.S., Cuenod C.A., de Bazelaire C., et al. Early modifications of hepatic perfusion measured by functional CT in a rat model of hepatocellular carcinoma using a blood pool contrast agent. Eur Radiol 14 (2004) 2125-2133
34. Van Beers B.E., Leconte I., Materne R., et al. Hepatic perfusion parameters in chronic liver disease: dynamic CT measurements correlated with disease severity. AJR Am J Roentgenol 176 (2001) 667-673
35. Zeng H., Sanyal S., and Mukhopadhyay D. Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively. J Biol Chem 276 (2001) 32714-32719
36. Heidenreich R., Machein M., Nicolaus A., et al. Inhibition of solid tumor growth by gene transfer of VEGF receptor-1 mutants. Int J Cancer 111 (2004) 348-357
37. Plate K.H., Breier G., Weich H.A., et al. Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms. Int J Cancer 59 (1994) 520-529
38. de Jong J.S., van Diest P.J., van der Valk P., et al. Expression of growth factors, growth inhibiting factors, and their receptors in invasive breast cancer. I: an inventory in search of autocrine and paracrine loops. J Pathol 184 (1998) 44-52