Pathological tau tangles localize to focal cortical dysplasia in older patients

Epilepsia

Volumn 48, Issue 8, 2007, Pages 1447-1454

  Sen, Arjune ^a   Thom, Maria ^a   Martinian, Lillian ^a   Harding, Brian ^b   Cross, J Helen ^c   Nikolic, Margareta ^d   Sisodiya, Sanjay M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

cdk5; Epilepsy; Focal cortical dysplasia; GSK3 ; Neurodegeneration; Tau

Indexed keywords

AMYLOID BETA PROTEIN;

ADULT; AGED; ARTICLE; BRAIN CORTEX; CELL COUNT; CLINICAL ARTICLE; CORTICAL DYSPLASIA; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL DIFFERENTIATION; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENESCENCE; SILVER STAINING;

ADOLESCENT; ADULT; AGE FACTORS; AGED, 80 AND OVER; AMYLOID BETA-PROTEIN; CELL COUNT; CEREBRAL CORTEX; CHILD; CHILD, PRESCHOOL; COLORING AGENTS; EPILEPSIES, PARTIAL; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT; MALE; MIDDLE AGED; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; NEURONS; PHOSPHORYLATION; TAU PROTEINS; TAUOPATHIES;

EID: 34547837494     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2007.01107.x     Document Type: Article

References (20)

1. Angelo M, Plattner F, Giese KP 2006) Cyclin-dependent kinase 5 in synaptic plasticity, learning and memory. Journal of Neurochemistry 99 : 353 370.
2. Bossy-Wetzel E, Schwarzenbacher R, Lipton SA 2004) Molecular pathways to neurodegeneration. Nature Medicine 10 (suppl S2 S9.
3. Bothwell M, Giniger E 2000) Alzheimer's disease: neurodevelopment converges with neurodegeneration. Cell 102 : 271 273.
4. Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai LH 1997) Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron 18 : 29 42.
5. Cotter D, Honavar M, Lovestone S, Raymond L, Kerwin R, Anderton B, Everall I 1999) Disturbance of Notch-1 and Wnt signalling proteins in neuroglial balloon cells and abnormal large neurons in focal cortical dysplasia in human cortex. Acta Neuropathoogica (Berl) 98 : 465 472.
6. Cruz JC, Tsai LH 2004) A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease. Current Opinion in Neurobiology 14 : 390 394.
7. de Silva R, Lashley T, Gibb G, Hanger D, Hope A, Reid A, Bandopadhyay R, Utton M, Strand C, Jowett T, Khan N, Anderton B, Wood N, Holton J, Revesz T, Lees A 2003) Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies. Neuropathology and Applied Neurobiology 29 : 288 302.
8. Duong T, De Rosa MJ, Poukens V, Vinters HV, Fisher RS 1994) Neuronal cytoskeletal abnormalities in human cerebral cortical dysplasia. Acta Neuropathologica (Berl) 87 : 493 503.
9. Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai LH 2005) Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 48 : 825 838.
10. Herrup K, Neve R, Ackerman SL, Copani A 2004) Divide and die: cell cycle events as triggers of nerve cell death. Journal of Neuroscience 24 : 9232 9239.
11. Kaytor MD, Orr HT 2002) The GSK3 beta signaling cascade and neurodegenerative disease. Current Opinion in Neurobiology 12 : 275 278.
12. Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH 2000) Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405 : 360 364.
13. Ohshima T, Ward JM, Huh CG, Longenecker G, Veeranna, Pant HC, Brady RO, Martin LJ, Kulkarni AB 1996) Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death. Proceedings of the National Academy of Sciences of the United States of America 93 : 11173 11178.
14. Palmini A, Najm I, Avanzini G, Babb T, Guerrini R, Foldvary-Schaefer N, Jackson G, Luders HO, Prayson R, Spreafico R, Vinters HV 2004) Terminology and classification of the cortical dysplasias. Neurology 62 : S2 S8.
15. Patrick GN, Zukerberg L, Nikolic M, de La MS, Dikkes P, Tsai LH 1999) Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402 : 615 622.
16. Plattner F, Angelo M, Giese KP 2006) The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation. Journal of Biological Chemistry 281 : 25457 25465.
17. Sisodiya SM 2004) Malformations of cortical development: burdens and insights from important causes of human epilepsy. Lancet Neurology 3 : 29 38.
18. Sisodiya SM, Thom M, Lin WR, Bajaj NP, Cross JH, Harding BN 2002) Abnormal expression of cdk5 in focal cortical dysplasia in humans. Neuroscience Letters 328 : 217 220.
19. Thom M, Martinian L, Sen A, Cross JH, Harding BN, Sisodiya SM 2005) Cortical neuronal densities and lamination in focal cortical dysplasia. Acta Neuropathologica (Berl). 110 : 383 392.
20. Weishaupt JH, Neusch C, Bahr M 2003) Cyclin-dependent kinase 5 (CDK5) and neuronal cell death. Cell and Tissue Research 312 : 1 8.