Estradiol and dihydrotestosterone regulate endothelial cell barrier function after hypergravity-induced alterations in MAPK activity

American Journal of Physiology - Cell Physiology

Volumn 293, Issue 2, 2007, Pages

  Sumanasekera, Wasana K ^a   Sumanasekera, Gamini U ^b   Mattingly, Kathleen A ^a   Dougherty, Susan M ^a   Keynton, Robert S ^b   Klinge, Carolyn M ^a  

^a University of Louisville School of Medicine   (United States)

^b University of Louisville   (United States)

Author keywords

Androgen; Estrogen; Paracellular permeability

Indexed keywords

ANDROGEN; ANDROSTANOLONE; CYTOCHROME C OXIDASE; ESTRADIOL; ESTROGEN; MITOGEN ACTIVATED PROTEIN KINASE; OCCLUDIN; PHOSPHATIDYLINOSITOL 3 KINASE;

AEROSPACE MEDICINE; ARTICLE; CARDIOVASCULAR RESPONSE; CELL FUNCTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; COSMONAUT; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC TRANSCRIPTION; GRAVITY; HORMONE ACTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

CAPILLARY PERMEABILITY; CELLS, CULTURED; DIHYDROTESTOSTERONE; ELECTRIC IMPEDANCE; ELECTRON TRANSPORT COMPLEX IV; ENDOTHELIAL CELLS; ENZYME ACTIVATION; ESTRADIOL; FEMALE; HUMANS; HYPERGRAVITY; HYPOTENSION, ORTHOSTATIC; MALE; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; SEX FACTORS; SPACE FLIGHT; TIGHT JUNCTIONS; TIME FACTORS; TYROSINE;

EID: 34547808104     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00418.2006     Document Type: Article

References (52)

1. Acconcia F, Ascenzi P, Bocedi A, Spisni E, Tomasi V, Trentalance A, Visca P, Marino M. Palmitoylation-dependent estrogen receptor - membrane localization: regulation by 17β-estradiol. Mol Biol Cell 16: 231-237, 2005.
2. Baisch JF, Wolfram G, Beck L, Drummer C, Stormer I, Buckey J, Blomqvist G. Orthostatic stress is necessary to maintain the dynamic range of cardiovascular control in space. Pflügers Arch 441: R52-R61, 2000.
3. Barletta F, Wong CW, McNally C, Komm BS, Katzenellenbogen B, Cheskis BJ. Characterization of the interactions of estrogen receptor and MNAR in the activation of cSrc. Mol Endocrinol 18: 1096-1108, 2004.
4. Baron S, Manin M, Beaudoin C, Leotoing L, Communal Y, Veyssiere G, Morel L. Androgen receptor mediates non-genomic activation of phosphatidylinositol 3-OH kinase in androgen-sensitive epithelial cells. J Biol Chem 279: 14579-14586, 2004.
5. Blomqvist CG, Buckey JC, Gaffney FA, Lane LD, Levine BD, Watenpaugh DE. Mechanisms of post-flight orthostatic intolerance. J Gravit Physiol 1: P122-P124, 1994.
6. Buckey JC, Lane LD, Levine BD, Watenpaugh DE, Wright SJ, Moore WE, Gaffney FA, Blomqvist CG. Orthostatic intolerance after spaceflight. J Appl Physiol 81: 7-18, 1996.
7. Bulayeva NN, Gametchu B, Watson CS. Quantitative measurement of estrogen-induced ERK 1 and 2 activation via multiple membrane-initiated signaling pathways. Steroids 69: 181-192, 2004.
8. Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev 23: 665-686, 2002.
9. Chen YH, Lu Q, Goodenough DA, Jeansonne B. Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells. Mol Biol Cell 13: 1227-1237, 2002.
10. Cho MM, Ziats NP, Abdul-Karim FW, Pal D, Goldfarb J, Utian WH, Gorodeski GI. Effects of estrogen on tight junctional resistance in cultured human umbilical vein endothelial cells. J Soc Gynecol Investig 5: 260-270, 1998.
11. Citi S. The molecular organization of tight junctions. J Cell Biol 121: 485-489, 1993.
12. Convertino VA. G-factor as a tool in basic research: mechanisms of orthostatic tolerance. J Gravit Physiol 6: P73-P76, 1999.
13. Dejana E. Endothelial adherens junctions: implications in the control of vascular permeability and angiogenesis. J Clin Invest 98: 1949-1953, 1996.
14. Drummer C, Gerzer R, Baisch F, Heer M. Body fluid regulation in micro-gravity differs from that on Earth: an overview. Pflügers Arch 441: R66-R72, 2000.
15. Drummer C, Heer M, Joosten M, Stormer I, Hesse C, Beck L, Wolfram G, Baisch F. Regulation and distribution of body fluid during a 6-day head-down tilt study in a randomized cross-over design. J Gravit Physiol 7: P187-P188, 2000.
16. Drummer C, Hesse C, Baisch F, Norsk P, Elmann-Larsen B, Gerzer R, Heer M. Water and sodium balances and their relation to body mass changes in microgravity. Eur J Clin Invest 30: 1066-1075, 2000.
17. Economos AC, Miquel J, Ballard RC, Blunden M, Lindseth KA, Fleming J, Philpott DE, Oyama J. Effects of simulated increased gravity on the rate of aging of rats: implications for the rate of living theory of aging. Arch Gerontol Geriatr 1: 349-363, 1982.
18. Farshori P, Kachar B. Redistribution and phosphorylation of occludin during opening and resealing of tight junctions in cultured epithelial cells. J Membr Biol 170: 147-156, 1999.
19. Fletcher NF, Brayden DJ, Brankin B, Worrall S, Callanan JJ. Growth and characterisation of a cell culture model of the feline blood-brain barrier. Vet Immunol Immunopathol 109: 233-244, 2006.
20. Gray GA, Sharif I, Webb DJ, Seckl JR. Oestrogen and the cardiovascular system: the good, the bad and the puzzling. Trends Pharmacol Sci 22: 152-156, 2001.
21. Gumbiner B. Structure, biochemistry, and assembly of epithelial tight junctions. Am J Physiol Cell Physiol 253: C749-C758, 1987.
22. Hirase T, Staddon JM, Saitou M, Ando-Akatsuka Y, Itoh M, Furuse M, Fujimoto K, Tsukita S, Rubin LL. Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci 110: 1603-1613, 1997.
23. Hoheisel D, Nitz T, Franke H, Wegener J, Hakvoort A, Tilling T, Galla HJ. Hydrocortisone reinforces the blood-brain properties in a serum free cell culture system. Biochem Biophys Res Commun 247: 312-315, 1998.
24. Huang AJ, Furie MB, Nicholson SC, Fischbarg J, Liebovitch LS, Silverstein SC. Effects of human neutrophil chemotaxis across human endothelial cell monolayers on the permeability of these monolayers to ions and macromolecules. J Cell Physiol 135: 355-366, 1988.
25. Hurst RD, Fritz IB. Properties of an immortalised vascular endothelial/glioma cell co-culture model of the blood-brain barrier. J Cell Physiol 167: 81-88, 1996.
26. Jacobson JR, Dudek SM, Singleton PA, Kolosova IA, Verin AD, Garcia JG. Endothelial cell barrier enhancement by ATP is mediated by the small GTPase Rac and cortactin. Am J Physiol Lung Cell Mol Physiol 291: L289-L295, 2006.
27. Jonsson D, Nilsson J, Odenlund M, Bratthall G, Broman J, Ekblad E, Lydrup ML, Nilsson BO. Demonstration of mitochondrial oestrogen receptor β and oestrogen-induced attenuation of cytochrome c oxidase subunit I expression in human periodontal ligament cells. Arch Oral Biol 52: 669-676, 2007.
28. 2-mediated permeability: role of MAPK and occludin. Am J Physiol Cell Physiol 279: C21-C30, 2000.
29. Klinge CM, Bambara RA, Hilf R. What differentiates antiestrogen-liganded vs. estradiol-liganded estrogen receptor action? Oncol Res 4: 137-144, 1992.
30. Klinge CM, Blankenship KA, Risinger KE, Bhatnagar S, Noisin EL, Sumanasekera WK, Zhao L, Brey DM, Keynton RS. Resveratrol and estradiol rapidly activate MAPK signaling through estrogen receptors alpha and beta in endothelial cells. J Biol Chem 280: 7460-7468, 2005.
31. Ku CY, Lu Q, Ussuf KK, Weinstock GM, Sanborn BM. Hormonal regulation of cytochrome oxidase subunit messenger RNAs in rat Sertoli cells. Mol Endocrinol 5: 1669-1676, 1991.
32. Leach CS, Alfrey CP, Suki WN, Leonard JI, Rambaut PC, Inners LD, Smith SM, Lane HW, Krauhs JM. Regulation of body fluid compartments during short-term spaceflight. J Appl Physiol 81: 105-116, 1996.
33. Louisy F, Andre-Deshays C, Cauquil D, Lazerges M, Lafaye C, Camus AL, Schroiff P, Gallina G. Air plethysmography: an alternative method for assessing peripheral circulatory adaptations during spaceflights. Eur J Appl Physiol 85: 383-391, 2001.
34. Motte S, Communi D, Pirotton S, Boeynaems JM. Involvement of multiple receptors in the actions of extracellular ATP: the example of vascular endothelial cells. Int J Biochem Cell Biol 27: 1-7, 1995.
35. Pantalos GM, Bennett TE, Sharp MK, Woodruff SJ, O'Leary DS, Gillars KJ, Schurfranz T, Everett SD, Lemon M, Schwartz J. The effect of gravitational acceleration on cardiac diastolic function: a biofluid mechanical perspective with initial results. Curr Pharm Biotechnol 6: 331-341, 2005.
36. Pantalos GM, Sharp MK, Woodruff SJ, O'Leary DS, Lorange R, Everett SD, Bennett TE, Shurfranz T. Influence of gravity on cardiac performance. Ann Biomed Eng 26: 931-943, 1998.
37. Razandi M, Oh P, Pedram A, Schnitzer J, Levin ER. ERs associate with and regulate the production of caveolin: implications for signaling and cellular actions. Mol Endocrinol 16: 100-115, 2002.
38. Rubin LL. Endothelial cells: adhesion and tight junctions. Curr Opin Cell Biol 4: 830-833, 1992.
39. Sakakibara A, Furuse M, Saitou M, Ando-Akatsuka Y, Tsukita S. Possible involvement of phosphorylation of occludin in tight junction formation. J Cell Biol 137: 1393-1401, 1997.
40. Schneeberger EE, Lynch RD. Structure, function, and regulation of cellular tight junctions. Am J Physiol Lung Cell Mol Physiol 262: L647-L661, 1992.
41. Seebach J, Dieterich P, Luo F, Schillers H, Vestweber D, Oberleithner H, Galla HJ, Schnittler HJ. Endothelial barrier function under laminar fluid shear stress. Lab Invest 80: 1819-1831, 2000.
42. Song RX, Fan P, Yue W, Chen Y, Santen RJ. Role of receptor complexes in the extranuclear actions of estrogen receptor α in breast cancer. Endocr Relat Cancer 13: S3-S13, 2006.
43. Spisni E, Bianco MC, Griffoni C, Toni M, D'Angelo R, Santi S, Riccio M, Tomasi V. Mechanosensing role of caveolae and caveolar constituents in human endothelial cells. J Cell Physiol 197: 198-204, 2003.
44. Sumanasekera WK, Zhao L, Ivanova M, Morgan DD, Noisin EL, Keynton RS, Klinge CM. Effect of estradiol and dihydrotestosterone on hypergravity-induced MAPK signaling and occludin expression in human umbilical vein endothelial cells. Cell Tissue Res 324: 243-253, 2006.
45. Tarbell JM, DeMaio L, Zaw MM. Effect of pressure on hydraulic conductivity of endothelial monolayers: rote of endothelial cleft shear stress. J Appl Physiol 87: 261-268, 1999.
46. Tretiach M, van Driel D, Gillies MC. Transendothelial electrical resistance of bovine retinal capillary endothelial cells is influenced by cell growth patterns: an ultrastructural study. Clin Exp Ophthalmol 31: 348-353, 2003.
47. Tsukamoto T, Nigam SK. Role of tyrosine phosphorylation in the reassembly of occludin and other tight junction proteins. Am J Physiol Renal Physiol 276: F737-F750, 1999.
48. van Breda E, Keizer HA, Vork MM, Surtel DA, de Jong YF, van der Vusse GJ, Glatz JF. Modulation of fatty-acid-binding protein content of rat heart and skeletal muscle by endurance training and testosterone treatment. Pflügers Arch 421: 274-279, 1992.
49. Wang Y, Zhang J, Yi XJ, Yu FS. Activation of ERK1/2 MAP kinase pathway induces tight junction disruption in human corneal epithelial cells. Exp Eye Res 78: 125-136, 2004.
50. Waters WW, Ziegler MG, Meck JV. Postspaceflight orthostatic hypotension occurs mostly in women and is predicted by low vascular resistance. J Appl Physiol 92: 586-594, 2002.
51. Ye L, Martin TA, Parr C, Harrison GM, Mansel RE, Jiang WG. Biphasic effects of 17-beta-estradiol on expression of occludin and transendothelial resistance and paracellular permeability in human vascular endothelial cells. J Cell Physiol 196: 362-369, 2003.
52. Zeng R, Li X, Gorodeski GI. Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation. J Clin Endocrinol Metab 89: 5145-5155, 2004.