메뉴 건너뛰기




Volumn 62, Issue 1, 2007, Pages 3-5

Sodium channel blockers as neuroprotectants in neuroinflammatory disease: A double-edged sword

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CARBAMAZEPINE; FLECAINIDE; GLUTAMATE RECEPTOR; LAMOTRIGINE; PHENYTOIN; SODIUM; SODIUM CHANNEL BLOCKING AGENT;

EID: 34547791749     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.21188     Document Type: Editorial
Times cited : (8)

References (35)
  • 2
    • 33644607018 scopus 로고    scopus 로고
    • Multiple sclerosis - the plaque and its pathogenesis
    • Frohman EM, Racke MK, Raine CS. Multiple sclerosis - the plaque and its pathogenesis. N Engl J Med 2006;354: 942-955.
    • (2006) N Engl J Med , vol.354 , pp. 942-955
    • Frohman, E.M.1    Racke, M.K.2    Raine, C.S.3
  • 3
    • 33947095512 scopus 로고    scopus 로고
    • The pathology of MS: New insights and potential clinical applications
    • Pittock SJ, Lucchinetti CF. The pathology of MS: new insights and potential clinical applications. Neurologist 2007; 13:45-56.
    • (2007) Neurologist , vol.13 , pp. 45-56
    • Pittock, S.J.1    Lucchinetti, C.F.2
  • 4
    • 33845294412 scopus 로고    scopus 로고
    • Remyelination is extensive in a subset of multiple sclerosis patients
    • Patrikios P, Stadelmann C, Kutzelnigg A, et al. Remyelination is extensive in a subset of multiple sclerosis patients. Brain 2006;129:3165-3172.
    • (2006) Brain , vol.129 , pp. 3165-3172
    • Patrikios, P.1    Stadelmann, C.2    Kutzelnigg, A.3
  • 5
    • 2542619146 scopus 로고    scopus 로고
    • Molecular changes in neurons in MS: Altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na/Ca exchanger
    • Craner MJ, Newcombe J, Black JA, et al. Molecular changes in neurons in MS: altered axonal expression of Nav1.2 and Nav1.6 sodium channels and Na/Ca exchanger. Proc Natl Acad Sci U S A 2004;101:8168-8173.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 8168-8173
    • Craner, M.J.1    Newcombe, J.2    Black, J.A.3
  • 6
    • 33751208544 scopus 로고    scopus 로고
    • Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis
    • Coman I, Aigrot MS, Seilhean D, et al. Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis. Brain 2006;129: 3186-3195.
    • (2006) Brain , vol.129 , pp. 3186-3195
    • Coman, I.1    Aigrot, M.S.2    Seilhean, D.3
  • 7
    • 0032576752 scopus 로고    scopus 로고
    • Axonal transection in the lesions of multiple sclerosis
    • Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998;338: 278-285.
    • (1998) N Engl J Med , vol.338 , pp. 278-285
    • Trapp, B.D.1    Peterson, J.2    Ransohoff, R.M.3
  • 8
    • 0037441487 scopus 로고    scopus 로고
    • Axonal loss in the pathology of MS: Consequences for understanding the progressive phase of the disease
    • Bjartmar C, Wujek JR, Trapp BD. Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the disease. J Neurol Sci 2003;206:165-171.
    • (2003) J Neurol Sci , vol.206 , pp. 165-171
    • Bjartmar, C.1    Wujek, J.R.2    Trapp, B.D.3
  • 9
    • 0036136532 scopus 로고    scopus 로고
    • Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis
    • Wujek JR, Bjartmar C, Richer E, et al. Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. J Neuropathol Exp Neurol 2002; 61:23-32.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 23-32
    • Wujek, J.R.1    Bjartmar, C.2    Richer, E.3
  • 10
    • 0031852514 scopus 로고    scopus 로고
    • Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study
    • De Stefano N, Matthews PM, Fu L, et al. Axonal damage correlates with disability in patients with relapsing-remitting multiple sclerosis. Results of a longitudinal magnetic resonance spectroscopy study. Brain 1998;121:1469-1477.
    • (1998) Brain , vol.121 , pp. 1469-1477
    • De Stefano, N.1    Matthews, P.M.2    Fu, L.3
  • 11
    • 1642482932 scopus 로고    scopus 로고
    • Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation
    • Inglese M, Mancardi GL, Pagani E, et al. Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. J Neurol Neurosurg Psychiatry 2004;75: 643-644.
    • (2004) J Neurol Neurosurg Psychiatry , vol.75 , pp. 643-644
    • Inglese, M.1    Mancardi, G.L.2    Pagani, E.3
  • 12
    • 31544467633 scopus 로고    scopus 로고
    • The window of therapeutic opportunity in multiple sclerosis: Evidence from monoclonal antibody therapy
    • Coles AJ, Cox A, Le Page E, et al. The window of therapeutic opportunity in multiple sclerosis: evidence from monoclonal antibody therapy. J Neurol 2006;253:98-108.
    • (2006) J Neurol , vol.253 , pp. 98-108
    • Coles, A.J.1    Cox, A.2    Le Page, E.3
  • 13
    • 34249749383 scopus 로고    scopus 로고
    • Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis
    • Metz I, Lucchinetti CF, Openshaw H, et al. Autologous haematopoietic stem cell transplantation fails to stop demyelination and neurodegeneration in multiple sclerosis. Brain 2007; 130:1254-1262.
    • (2007) Brain , vol.130 , pp. 1254-1262
    • Metz, I.1    Lucchinetti, C.F.2    Openshaw, H.3
  • 14
    • 0036546066 scopus 로고    scopus 로고
    • New concepts in the immunopathogenesis of multiple sclerosis
    • Hemmer B, Archelos JJ, Hartung HP. New concepts in the immunopathogenesis of multiple sclerosis. Nat Rev Neurosci 2002;3:291-301.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 291-301
    • Hemmer, B.1    Archelos, J.J.2    Hartung, H.P.3
  • 15
    • 0029087953 scopus 로고
    • Voltage-gated calcium channels in CNS white matter: Role in anoxic injury
    • Fern R, Ransom BR, Waxman SG. Voltage-gated calcium channels in CNS white matter: role in anoxic injury. J Neurophysiol 1995;74:369-377.
    • (1995) J Neurophysiol , vol.74 , pp. 369-377
    • Fern, R.1    Ransom, B.R.2    Waxman, S.G.3
  • 16
    • 0033616414 scopus 로고    scopus 로고
    • The role of voltage-gated Ca2+ channels in anoxic injury of spinal cord white matter
    • Imaizumi T, Kocsis JD, Waxman SG. The role of voltage-gated Ca2+ channels in anoxic injury of spinal cord white matter. Brain Res 1999;817:84-92.
    • (1999) Brain Res , vol.817 , pp. 84-92
    • Imaizumi, T.1    Kocsis, J.D.2    Waxman, S.G.3
  • 17
    • 33644520285 scopus 로고    scopus 로고
    • NMDA receptors mediate Ca accumulation in central nervous system myelin during chemical ischemia
    • Micu I, Coderre E, Jiang Q, et al. NMDA receptors mediate Ca accumulation in central nervous system myelin during chemical ischemia. Nature 2006;439:988-992.
    • (2006) Nature , vol.439 , pp. 988-992
    • Micu, I.1    Coderre, E.2    Jiang, Q.3
  • 18
    • 0141750468 scopus 로고    scopus 로고
    • Depolarization-induced Ca2+ release in ischemic spinal cord white matter involves L-type Ca2+ channel activation of ryanodine receptors
    • Ouardouz M, Nikolaeva M, Coderre E, et al. Depolarization-induced Ca2+ release in ischemic spinal cord white matter involves L-type Ca2+ channel activation of ryanodine receptors. Neuron 2003;40:53-63.
    • (2003) Neuron , vol.40 , pp. 53-63
    • Ouardouz, M.1    Nikolaeva, M.2    Coderre, E.3
  • 19
    • 0026556810 scopus 로고
    • Ionic mechanisms of anoxic injury in mammalian CNS white matter: Role of Na+ channels and Na+-Ca2+ exchanger
    • Stys PK, Waxman SG, Ransom BR. Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na+-Ca2+ exchanger. J Neurosci 1992;12: 430-439.
    • (1992) J Neurosci , vol.12 , pp. 430-439
    • Stys, P.K.1    Waxman, S.G.2    Ransom, B.R.3
  • 20
    • 0035875713 scopus 로고    scopus 로고
    • AMPA/kainate receptor activation mediates hypoxic oligodendrocyte death and axonal injury in cerebral white matter
    • Tekkok SB, Goldberg MP. AMPA/kainate receptor activation mediates hypoxic oligodendrocyte death and axonal injury in cerebral white matter. J Neurosci 2001;21: 4237-4248.
    • (2001) J Neurosci , vol.21 , pp. 4237-4248
    • Tekkok, S.B.1    Goldberg, M.P.2
  • 21
    • 20444386558 scopus 로고    scopus 로고
    • General mechanisms of axonal damage and its prevention
    • Stys PK. General mechanisms of axonal damage and its prevention. J Neurol Sci 2005;233:3-13.
    • (2005) J Neurol Sci , vol.233 , pp. 3-13
    • Stys, P.K.1
  • 22
    • 33644817756 scopus 로고    scopus 로고
    • Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
    • Dutti R, McDonough J, Yin X, et al. Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients. Ann Neurol 2006;59:478-489.
    • (2006) Ann Neurol , vol.59 , pp. 478-489
    • Dutti, R.1    McDonough, J.2    Yin, X.3
  • 23
    • 33846025116 scopus 로고    scopus 로고
    • Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis
    • Qi X, Lewin AS, Sun L, et al. Mitochondrial protein nitration primes neurodegeneration in experimental autoimmune encephalomyelitis. J Biol Chem 2006;281:31950-31962.
    • (2006) J Biol Chem , vol.281 , pp. 31950-31962
    • Qi, X.1    Lewin, A.S.2    Sun, L.3
  • 24
    • 2142814324 scopus 로고    scopus 로고
    • Axonal degeneration in MS: Is it time for neuroprotective strategies?
    • Stys PK. Axonal degeneration in MS: is it time for neuroprotective strategies? Ann Neurol 2004;55:601-603.
    • (2004) Ann Neurol , vol.55 , pp. 601-603
    • Stys, P.K.1
  • 25
    • 0242508548 scopus 로고    scopus 로고
    • Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo
    • Lo AC, Saab CY, Black JA, et al. Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivo. J Neurophysiol 2003;90:3566-3571.
    • (2003) J Neurophysiol , vol.90 , pp. 3566-3571
    • AC, L.1    Saab, C.Y.2    Black, J.A.3
  • 26
    • 2142760098 scopus 로고    scopus 로고
    • Axonal protection using flecainide in experimental autoimmune encephalomyelitis
    • Bechtold DA, Kapoor R, Smith KJ. Axonal protection using flecainide in experimental autoimmune encephalomyelitis. Ann Neurol 2004;55:607-616.
    • (2004) Ann Neurol , vol.55 , pp. 607-616
    • Bechtold, D.A.1    Kapoor, R.2    Smith, K.J.3
  • 27
    • 33744489487 scopus 로고    scopus 로고
    • Axonal protection achieved in a model of multiple sclerosis using lamotrigine
    • Bechtold DA, Miller SJ, Dawson AC, et al. Axonal protection achieved in a model of multiple sclerosis using lamotrigine. J Neurol 2006;253:1542-1551.
    • (2006) J Neurol , vol.253 , pp. 1542-1551
    • Bechtold, D.A.1    Miller, S.J.2    Dawson, A.C.3
  • 28
    • 33751166454 scopus 로고    scopus 로고
    • Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE
    • Black JA, Liu S, Hains BC, et al. Long-term protection of central axons with phenytoin in monophasic and chronic-relapsing EAE. Brain 2006;129:3196-3208.
    • (2006) Brain , vol.129 , pp. 3196-3208
    • Black, J.A.1    Liu, S.2    Hains, B.C.3
  • 29
    • 0033958462 scopus 로고    scopus 로고
    • Glutamate excitotoxicity in a model of multiple sclerosis
    • Pitt D, Werner P, Raine CS. Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med 2000;6:67-70.
    • (2000) Nat Med , vol.6 , pp. 67-70
    • Pitt, D.1    Werner, P.2    Raine, C.S.3
  • 30
    • 0033963231 scopus 로고    scopus 로고
    • Autoimmune encephalomyelitis ameliorated by AMPA antagonists
    • Smith T, Groom A, Zhu B, et al. Autoimmune encephalomyelitis ameliorated by AMPA antagonists. Nat Med 2000;6: 62-66.
    • (2000) Nat Med , vol.6 , pp. 62-66
    • Smith, T.1    Groom, A.2    Zhu, B.3
  • 32
    • 0141861944 scopus 로고    scopus 로고
    • Riluzole suppresses experimental autoimmune encephalomyelitis: Implications for the treatment of multiple sclerosis
    • Gilgun-Sherki Y, Panet H, Melamed E, et al. Riluzole suppresses experimental autoimmune encephalomyelitis: implications for the treatment of multiple sclerosis. Brain Res 2003; 989:196-204.
    • (2003) Brain Res , vol.989 , pp. 196-204
    • Gilgun-Sherki, Y.1    Panet, H.2    Melamed, E.3
  • 33
    • 3543068828 scopus 로고    scopus 로고
    • Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis
    • Brand-Schieber E, Werner P. Calcium channel blockers ameliorate disease in a mouse model of multiple sclerosis. Exp Neurol 2004;189:5-9.
    • (2004) Exp Neurol , vol.189 , pp. 5-9
    • Brand-Schieber, E.1    Werner, P.2
  • 34
    • 34547773583 scopus 로고    scopus 로고
    • Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine
    • Black JA, Liu S, Carrithers M, et al. Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepine. Ann Neurol 2007;62:21-33.
    • (2007) Ann Neurol , vol.62 , pp. 21-33
    • Black, J.A.1    Liu, S.2    Carrithers, M.3
  • 35
    • 34250211729 scopus 로고    scopus 로고
    • v1.5 in the macrophage late endosome regulates endosomal acidification
    • v1.5 in the macrophage late endosome regulates endosomal acidification. J Immunol 2007;178:7822-7832.
    • (2007) J Immunol , vol.178 , pp. 7822-7832
    • Carrithers, M.D.1    Dib-Hajj, S.2    Carrithers, L.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.