Crystallographic and Mass Spectrometric Characterisation of eIF4E with N7-alkylated Cap Derivatives

Journal of Molecular Biology

Volumn 372, Issue 1, 2007, Pages 7-15

  Brown, Christopher J ^a   McNae, Iain ^a   Fischer, Peter M ^b   Walkinshaw, Malcolm D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b CYCLACEL LTD   (United Kingdom)

Author keywords

cap derivative; eIf4E; mRNA; translation

Indexed keywords

BENZYL DERIVATIVE; CATION; GUANOSINE DERIVATIVE; GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATE; INITIATION FACTOR 4E; TRYPTOPHAN;

ALKYLATION; ARTICLE; BINDING SITE; CRYSTALLOGRAPHY; DISSOCIATION CONSTANT; GAS; HUMAN; MASS SPECTROMETRY; METHYLATION; PRIORITY JOURNAL;

EUKARYOTA;

EID: 34547788872     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.06.033     Document Type: Article

References (33)

1. Gingras A.C., Raught B., and Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68 (1999) 913-963
2. Gingras A.C., Raught B., and Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes Dev. 15 (2001) 807-826
3. Ueda T., Watanabe-Fukunaga R., Fukuyama H., Nagata S., and Fukunaga R. Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol. Cell. Biol. 24 (2004) 6539-6549
4. Rhoads R.E. Cap recognition and the entry of mRNA into the protein synthesis initiation cycle. Trends Biochem. Sci. 13 (1988) 52-56
5. Graff J.R., and Zimmer S.G. Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs. Clin. Exp. Metastasis 20 (2003) 265-273
6. De Benedetti A., and Graff J.R. eIF-4E expression and its role in malignancies and metastases. Oncogene 23 (2004) 3189-3199
7. Graff J.R., and Zimmer S.G. Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs. Clin. Exp. Metastasis 20 (2003) 265-273
8. Topisirovic I., Ruiz-Gutierrez M., and Borden K.L.B. Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities. Cancer Res. 64 (2004) 8639-8642
9. Mamane Y., Petroulakis E., Rong L., Yoshida K., Ler L.W., and Sonenberg N. eIF4E - from translation to transformation. Oncogene 23 (2004) 3172-3179
10. Graff J.R., Konicek B.W., Lynch R.L., Vincent T.M., Bailey S.N., Schwier P., et al. Depleting eIF4E expression with a novel eIF4E targeted antisense oligonucleotide suppresses eIF4E expression and human xenograft tumor growth without overt toxicity. Proc. Am. Assoc. Cancer Res. 46 (2005) Abs. 576
11. Kentsis A., Topisirovic I., Culjkovic B., Shao L., and Borden K.L.B. Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap. Proc. Natl Acad. Sci. USA 101 (2004) 18105-18110
12. Kentsis A., Volpon L., Topisirovic I., Soll C.E., Culjkovic B., Shao L., and Borden K.L.B. Further evidence that ribavirin interacts with eIF4E. RNA 11 (2005) 1762-1766
13. Grudzien E., Stepinski J., Jankowska-Anyszka M., Stolarski R., Darzynkiewicz E., and Rhoads R.E. Novel cap analogs for in vitro synthesis of mRNAs with high translational efficiency. RNA 10 (2004) 1479-1487
14. Cai A., Jankowska-Anyszka M., Centers A., Chlebick L., Stepinski J., Stolarski R., et al. Quantitative assessment of mRNA cap analogues as inhibitors of in vitro translation. Biochemistry 38 (1999) 8538-8547
15. Niedzwiecka A., Marcotrigiano J., Stepinski J., Jankowska-Anyszka M., Wyslouch-Cieszynska A., Dadlez M., et al. Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5′ cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. J. Mol. Biol. 319 (2002) 615-635
16. Marcotrigiano J., Gingras A.-C., Sonenberg N., and Burley S.K. Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell 89 (1997) 951-961
17. Matsuo H., Li H., McGuire A.M., Fletcher C.M., Gingras A.-C., Sonenberg N., and Wagner G. Structure of translation factor eIF4E bound to m7GDP and interaction with 4E-binding protein. Nature Struct. Biol. 4 (1997) 717-724
18. Tomoo K., Shen X., Okabe K., Nozoe Y., Fukuhara S., Morino S., et al. Crystal structures of 7-methylguanosine 5prime prime or minute-triphosphate (m7GTP)- and P1-7-methylguanosine-P3-adenosine-5prime prime or minute,5prime prime or minute-triphosphate (m7GpppA)-bound human full-length eukaryotic initiation factor 4E: biological importance of the C-terminal flexible region. Biochem. J. 362 (2002) 539-544
19. Niedzwiecka A., Darzynkiewicz E., and Stolarski R. Thermodynamics of mRNA 5' cap binding by eukaryotic translation initiation factor eIF4E. Biochemistry 43 (2004) 13305-13317
20. Blachut-Okrasinska E., Bojarska E., Niedzwiecka A., Chlebicka L., Darzynkiewicz E., Stolarski R., et al. Stopped-flow and Brownian dynamics studies of electrostatic effects in the kinetics of binding of 7-methyl-GpppG to the protein eIF4E. Eur. Biophys. J. 29 (2000) 487-498
21. Loo J.A. Studying non-covalent protein complexes by electrospray ionization mass spectrometry. Mass Spectrom. Rev. 16 (1997) 1-23
22. Robinson C.V., Chung E.W., Kragelund B.B., Knudsen J., Aplin R.T., Poulsen F.M., and Dobson C.M. Probing the nature of non-covalent interactions by mass spectrometry. A study of protein-CoA ligand binding and assembly. J. Am. Chem. Soc. 118 (1996) 8646-8653
23. Marcotrigiano J., Gingras A.-C., Sonenberg N., and Burley S.K. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Mol. Cell 3 (1999) 707-716
24. Mazza C., Segref A., Mattaj I.W., and Cusack S. Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. EMBO J. 21 (2002) 5548-5557
25. Rosettani P.F., Knapp S FAU - Vismara M.-G., Vismara MG FAU - Rusconi L., Rusconi L.F., and Cameron A.D. Structures of the human eIF4E homologous protein, h4EHP, in its m(7)GTP-bound and unliganded forms. J. Mol. Biol. 368 (2007) 691-705
26. Hodel A.E., Gershon P.D., and Quiocho F.A. Structural basis for sequence-nonspecific recognition of 5′-capped mRNA by a cap-modifying enzyme. Mol. Cell 1 (1998) 443-447
27. Hodel A.E., Gershon P.D., Shi X., Wang S.-M., and Quiocho F.A. Specific protein recognition of an mRNA cap through its alkylated base. Nature Struct. Biol. 4 (1997) 350-354
28. Fletcher C.M., McGuire A.M., Gingras A.-C., Li H., Matsuo H., Sonenberg N., and Wagner G. 4E binding proteins inhibit the translation factor eIF4E without folded structure. Biochemistry 37 (1998) 9-15
29. Quiocho F.A., Hu G., and Gershon P.D. Structural basis of mRNA cap recognition by proteins. Curr. Opin. Struct. Biol. 10 (2000) 78-86
30. Tomoo K., Shen X., Okabe K., Nozoe Y., Fukuhara S., Morino S., et al. Structural features of human initiation factor 4E, studied by X-ray crystal analyses and molecular dynamics simulations. J. Mol. Biol. 328 (2003) 365-383
31. Volpon L., Osborne M.J., Topisirovic I., Siddiqui N., and Borden K.L. Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands. EMBO J. 25 (2006) 5138-5149
32. Fischer P.M. The design of drug candidate molecules as selective inhibitors of therapeutically relevant kinases. Curr. Med. Chem. 11 (2004) 1563-1583
33. Ghosh P., Park C., Peterson M.S., Bitterman P.B., Polunovsky V.A., and Wagner C.R. Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP. Bioorg. Med. Chem. Letters 15 (2005) 2177-2180