Inhibition of trifluoperazine-induced DNA fragmentation by cyclic AMP mediated signaling

Molecules and Cells

Volumn 9, Issue 6, 1999, Pages 596-602

  Kang, Ung Gu ^b   Kim, Myung Jong ^c   Suh, Pann Ghill ^c   Ryu, Sung Ho ^c   Park, Joo Bae ^d   Kim, Jung Hye ^a   Kim, Yong Sik ^b   Lee, Young Han ^a  

^a Yeungnam University College of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Pohang University of Science and Technology (POSTECH)   (South Korea)

^d Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Calcium; Calmodulin; Cyclic AMP; DNA Fragmentation; PC12 Cell; Trifluoperazine

Indexed keywords

ADENYLATE CYCLASE TOXIN; BORDETELLA VIRULENCE FACTOR; BROXURIDINE; BUCLADESINE; CHOLERA TOXIN; CYCLIC AMP; DNA FRAGMENT; FORSKOLIN; TRIFLUOPERAZINE;

ANIMAL; ARTICLE; CALCIUM SIGNALING; CELL STRAIN; CELL SURVIVAL; DRUG EFFECT; METABOLISM; RAT; SIGNAL TRANSDUCTION;

ADENYLATE CYCLASE TOXIN; ANIMALS; BROMODEOXYURIDINE; BUCLADESINE; CALCIUM SIGNALING; CELL SURVIVAL; CHOLERA TOXIN; CYCLIC AMP; DNA FRAGMENTATION; FORSKOLIN; PC12 CELLS; RATS; SIGNAL TRANSDUCTION; TRIFLUOPERAZINE; VIRULENCE FACTORS, BORDETELLA;

EID: 0033621288     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Abe, K., Sekizawa, T., and Kogure K. (1986) Biphasic effects of chlorpromazine on cell viability in a neuroblastoma cell line. Neurosci. Lett. 71, 335-339.
2. Ahn, J.-H., Ko, Y.-G., Park, W.-Y., Kang, Y.-S., Chung, H. Y., and Seo, J.-S. (1999) Suppression of ceramide-mediated apoptosis by HSP70. Mol. Cells 9, 200-206.
3. Akompong, T., Spencer, R. L., and McEwen, B. S. (1994) Cytosolic phospholipase C activity: II. Relationship to concanavalin A-induced phosphatidylinositol-turnover in splenocytes. J. Cell Biochem. 56, 409-417.
4. Batistatou, A. and Greene, L. A. (1993) Internucleosomal DNA cleavage and neuronal cell survival/death. J. Cell. Biol. 122, 523-532.
5. Carter, H. R., Wallace, M. A., and Fain, J. N. (1990) Purification and characterization of PLC-beta m, a muscarinic cholinergic regulated phospholipase C from rabbit brain membrane Biochim. Biophys. Acta 1054, 119-128.
6. Chiesa, R., Angeretti, N., Del Bo, R., Lucca, E., Munna, E., and Forloni, G. (1998) Extracellular calcium deprivation in astrocytes: regulation of mRNA expression and apoptosis. J. Neurochem. 70, 1474-1483.
7. Dubovsky, S. L., Murphy, J., Christiano, J., and Lee, C. (1992) The calcium second messenger system in bipolar disorders: data supporting new research directions. J. Neuropsychiatry Clin. Neurosci. 4, 3-14.
8. Grasl-Kraupp, B., Ruttkay-Nedecky, B., Koudelka, H., Bukowska, K., Bursch, W., and Schulte-Hermann, R. (1995) In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: a cautionary note. Hepatology 21, 1465-1468.
9. Hait, W. N., Gesmonde, J. F., and Lazo, J. S. (1994) Effect of anti-calmodulin drugs on the growth and sensitivity of C6 rat glioma cells to bleomycin. Anticancer Res. 14, 1711-1721.
10. 2+ channel current in PC12 cells. Eur. J. Pharmacol. 314, 143-150.
11. Kaiya, H. (1992) Second messenger imbalance hypothesis of schizophrenia. Prostaglandins Leukot. Essent. Fatty Acids 46, 33-38.
12. 2-induced apoptosis in PC12 cells by glutathione independent mechanism. Neurosci. Lett. 212, 179-182.
13. Kobayashi, Y. and Shinozawa, T. (1997) Effect of dibutyryl cAMP and several reagents on apoptosis in PC12 cells induced by a sialoglycopeptide from bovine brain. Brain Res. 778, 309-317.
14. Kumar, R., Holian, O., Cook, B., and Roshani, P. (1997) Inhibition of rat brain protein kinase C by lipid soluble psychotropics. Neurochem. Res. 22, 1-10.
15. Lin, W. W. (1995) Potentiation of stimulus-induced phosphoinositide breakdown by calmodulin antagonists in C6 glioma. Arch. Pharmacol. 352, 679-684.
16. Lindenboim, L., Haviv, R., and Stein, R. (1995) Inhibition of drug-induced apoptosis by survival factors in PC12 cells. J. Neurochem. 64, 1054-1063.
17. Lopez-Girona, A., Colomer, J., Pujol, M. J., Bachs, O., and Agell, N. (1992) Calmodulin regulates DNA polymerase alpha activity during proliferative activation of NRK cells. Biochem. Biophys. Res. Commun. 184, 1517-1523.
18. Matsui, T., Nakao, Y., Kobayashi, N., Koizumi, T., Nakagawa, T., Kishihara, M., and Fujita, T. (1985) Effects of calmodulin antagonists and cytochalasins on proliferation and differentiation of human promyelocytic leukemia cell line HL-60. Cancer Res. 45, 311-316.
19. McConkey, D. J. (1998) Biochemical determinants of apoptosis and necrosis. Toxicol. Lett. 99, 157-168.
20. McConkey, D. J. and Orrenius, S. (1996) Signal transduction pathways in apoptosis. Stem Cells 14, 619-631.
21. Oberhammer, F., Frisch, G., Schmied, M., Pavelka, M., Printz, D., Purchio, T., Lassmann, H., and Schulte-Hermann, R. (1993) Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kilobase fragments prior to or in the absence of internucleosomal fragmentation. EMBO J. 12, 3679-3684.
22. 2+ dependent mechanisms of cytotoxicity and programmed cell death. Toxicol. Lett. 64/65, 357-364.
23. Osborn, M. and Weber, K. (1980) Damage of cellular functions by trifluoperazine a calmodulin-specific drug. Exp. Cell. Res. 130, 484-488.
24. 2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. FASEB J. 7, 453-463.
25. Reddy, R. D. and Yao, J. K. (1996) Free radical pathology in schizophrenia: a review. Prostaglandins Leukot. Essent. Fatty Acids 55, 33-43.
26. Sagara, Y. (1998) Induction of reactive oxygen species in neurons by haloperidol. J. Neurochem. 71, 1002-1012.
27. Schulze-Osthoff, K., Walczak, H., Droge, W., and Krammer, P. H. (1994) Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell Biol. 127, 15-20.
28. Seeman, P. and Lee, T. (1975) Antipsychotic drugs: direct correlation between clinical potency and presynaptic action on dopamine neurons. Science 188, 1217-1219.
29. Soares, J. C. and Mallinger, A. G. (1997) Intracellular phosphatidylinositol pathway abnormalities in bipolar disorder patients. Psychopharmacol. Bull. 33, 685-691.
30. Strobl, J. S., Kirkwood, K. L., Lantz, T. K., Lewine, M. A., Peterson, V. A., and Worley, J. F. III. (1990) Inhibition of human breast cancer cell proliferation in tissue culture by the neuroleptic agents pimozide and thioridazine. Cancer Res. 50, 5399-5405.
31. Tsai, G., Goff, D. C., Chang, R.W., Flood, J., Baer, L., and Coyle, J. T. (1998) Markers of glutamatergic neurotransmission and oxidative stress associated with tardive dyskinesia. Am. J. Psychiatry 155, 1207-1213.
32. 2+ uptake induced by amyloid beta protein (25-35) in vitro. Brain Res. 748, 184-188.
33. Vilner, B. J., de Costa, B. R., and Bowen, W. D. (1995) Cytotoxic effects of sigma ligands: sigma receptor-mediated alterations in cellular morphology and viability. J. Neurosci. 15, 117-134.
34. Zinetti, M., Galli, G., Demitri, M. T., Fantuzzi, G., Minto, M., Ghezzi, P., Alzani, R., Cozzi, E., and Fratelli, M. (1995) Chlorpromazine inhibits tumor necrosis factor synthesis and cytotoxicity in vitro. Immunology 86, 416-421.