-
1
-
-
0035756986
-
Chemistry and chemical biology of Taxane anticancer agents
-
Miller ML, Ojima I. Chemistry and chemical biology of Taxane anticancer agents. Chem Record 2001; 1: 195-211.
-
(2001)
Chem Record
, vol.1
, pp. 195-211
-
-
Miller, M.L.1
Ojima, I.2
-
2
-
-
0032883001
-
Molecular effects of paclitaxel: Myths and reality (a critical review)
-
Blagosklonny MV, Fojo T. Molecular effects of paclitaxel: Myths and reality (a critical review). Int J Cancer 1999; 83: 151-6.
-
(1999)
Int J Cancer
, vol.83
, pp. 151-156
-
-
Blagosklonny, M.V.1
Fojo, T.2
-
3
-
-
0018387446
-
Promotion of microtubule assembly in vitro by Taxol
-
Schiff PB, Fant J, Horwitz SB. Promotion of microtubule assembly in vitro by Taxol. Nature 1979; 277: 665-7.
-
(1979)
Nature
, vol.277
, pp. 665-667
-
-
Schiff, P.B.1
Fant, J.2
Horwitz, S.B.3
-
4
-
-
0033052777
-
Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death
-
Dumontet C, Sikic BI. Mechanisms of action of and resistance to antitubulin agents: Microtubule dynamics, drug transport, and cell death. J Clin Oncol 1999; 17: 1061-70.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1061-1070
-
-
Dumontet, C.1
Sikic, B.I.2
-
5
-
-
0037303101
-
Paclitaxel resistance: Molecular mechanisms and pharmacologic manipulation
-
Yusuf RZ, Duan Z, Lamendola DE, et al. Paclitaxel resistance: Molecular mechanisms and pharmacologic manipulation. Curr Cancer Drug Targets 2003; 3: 1-19.
-
(2003)
Curr Cancer Drug Targets
, vol.3
, pp. 1-19
-
-
Yusuf, R.Z.1
Duan, Z.2
Lamendola, D.E.3
-
7
-
-
25444465116
-
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function
-
Escuin D, Kline ER, Giannakakou P. Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function. Cancer Res 2005; 65: 9021-8.
-
(2005)
Cancer Res
, vol.65
, pp. 9021-9028
-
-
Escuin, D.1
Kline, E.R.2
Giannakakou, P.3
-
8
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh NJ, Escuin D, LaVallee TM, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell 2003; 3: 363-75.
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
-
9
-
-
0037096732
-
Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene
-
Comerford KM, Wallace TJ, Karhausen J, Louis NA, Montalto MC, Colgan S. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 2002; 62: 3387-94.
-
(2002)
Cancer Res
, vol.62
, pp. 3387-3394
-
-
Comerford, K.M.1
Wallace, T.J.2
Karhausen, J.3
Louis, N.A.4
Montalto, M.C.5
Colgan, S.6
-
10
-
-
0038282482
-
The hypoxia-inducible factor-1 is a negative factor for tumor therapy
-
Unruh A, Ressel A, Mohamed HG, et. al. The hypoxia-inducible factor-1 is a negative factor for tumor therapy. Oncogene 2003; 22: 3213-20.
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
Ressel, A.2
Mohamed, H.G.3
-
11
-
-
12144287046
-
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via HIF-1-dependent and -independent mechanisms and contributes to drug resistance
-
Erler JT, Cawthorne CJ, Williams KJ, et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via HIF-1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol 2004; 24: 2875-89.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 2875-2889
-
-
Erler, J.T.1
Cawthorne, C.J.2
Williams, K.J.3
-
12
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semanza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3: 721-32.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 721-732
-
-
Semanza, G.L.1
-
13
-
-
2942590732
-
Exploring tumor hypoxia in cancer treatment
-
Brown JM, Wilson WR. Exploring tumor hypoxia in cancer treatment. Nat Rev Cancer 2004; 4: 437-47.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
Wilson, W.R.2
-
14
-
-
0141956303
-
Overexpression of hypoxia-inducible-factor 1 alpha (HIF-1alpha) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage
-
Kurokawa T, Miyamoto M, Kato K, et al. Overexpression of hypoxia-inducible-factor 1 alpha (HIF-1alpha) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Br J Cancer 2003; 89: 1042-7.
-
(2003)
Br J Cancer
, vol.89
, pp. 1042-1047
-
-
Kurokawa, T.1
Miyamoto, M.2
Kato, K.3
-
15
-
-
12944266844
-
The expression of hypoxia-inducible factor 1 alpha is a favorable independent prognostic factor in renal cell carcinoma
-
Lidgren A, Hedberg Y, Grankvist K, Rasmuson T, Vasko J, Ljungberg B. The expression of hypoxia-inducible factor 1 alpha is a favorable independent prognostic factor in renal cell carcinoma. Clin Cancer Res 2005; 11: 1129-35.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1129-1135
-
-
Lidgren, A.1
Hedberg, Y.2
Grankvist, K.3
Rasmuson, T.4
Vasko, J.5
Ljungberg, B.6
-
16
-
-
3042816190
-
Hypoxia-inducible factor-1 alpha in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathway
-
Swinson DE, Jones JL, Cox G, Richardson D, Harris AL, O'Byrne KJ. Hypoxia-inducible factor-1 alpha in non small cell lung cancer: Relation to growth factor, protease and apoptosis pathway. Int J Cancer 2004; 111: 43-50.
-
(2004)
Int J Cancer
, vol.111
, pp. 43-50
-
-
Swinson, D.E.1
Jones, J.L.2
Cox, G.3
Richardson, D.4
Harris, A.L.5
O'Byrne, K.J.6
-
17
-
-
26844502441
-
HIF 1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor
-
Fillies T, Werkmeister R, Van Diest PJ, Brandt B, Joos U, Buerger H. HIF 1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor. BMC Cancer 2005; 5: 84-92.
-
(2005)
BMC Cancer
, vol.5
, pp. 84-92
-
-
Fillies, T.1
Werkmeister, R.2
Van Diest, P.J.3
Brandt, B.4
Joos, U.5
Buerger, H.6
-
18
-
-
31044444974
-
Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1
-
Brown LM, Cowen RL, Debray C, et al. Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1. Mol Pharmacol 2006; 69: 411-18.
-
(2006)
Mol Pharmacol
, vol.69
, pp. 411-418
-
-
Brown, L.M.1
Cowen, R.L.2
Debray, C.3
-
19
-
-
0038282482
-
The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
-
Unruh A, Ressel A, Mohamed HG, et al. The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene 2003; 22: 3213-20.
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
Ressel, A.2
Mohamed, H.G.3
-
20
-
-
33746082136
-
Impact of hypoxia on taxol-induced apoptosis in human ovarian cancer cell line A2780 and its mechanism
-
Huang L, Ao QL, Li F, Xing H, Lu YP. Impact of hypoxia on taxol-induced apoptosis in human ovarian cancer cell line A2780 and its mechanism. Ai Zheng 2005; 24: 408-13.
-
(2005)
Ai Zheng
, vol.24
, pp. 408-413
-
-
Huang, L.1
Ao, Q.L.2
Li, F.3
Xing, H.4
Lu, Y.P.5
-
21
-
-
0034016273
-
Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation
-
Yano S, Herbst RS, Shinohara H, et al. Treatment for malignant pleural effusion of human lung adenocarcinoma by inhibition of vascular endothelial growth factor receptor tyrosine kinase phosphorylation. Clin Cancer Res 2000; 6: 957-65.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 957-965
-
-
Yano, S.1
Herbst, R.S.2
Shinohara, H.3
-
22
-
-
23844461100
-
Evaluating hypoxia-inducible factor-1 as a cancer therapeutic target via inducible RNA interference in vivo
-
Li L-M, Lin X-Y, Staver M, et al. Evaluating hypoxia-inducible factor-1 as a cancer therapeutic target via inducible RNA interference in vivo. Cancer Res 2005; 65: 7249-58.
-
(2005)
Cancer Res
, vol.65
, pp. 7249-7258
-
-
Li, L.-M.1
Lin, X.-Y.2
Staver, M.3
-
23
-
-
27244433455
-
Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals
-
Harada H, Kizaka-Kondoh S, Hiraoka M. Optical imaging of tumor hypoxia and evaluation of efficacy of a hypoxia-targeting drug in living animals. Mol Imaging 2005; 4: 182-93.
-
(2005)
Mol Imaging
, vol.4
, pp. 182-193
-
-
Harada, H.1
Kizaka-Kondoh, S.2
Hiraoka, M.3
-
24
-
-
0345060457
-
Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice
-
Onn A, Isobe T, Itasaka S, et al. Development of an orthotopic model to study the biology and therapy of primary human lung cancer in nude mice. Clin Cancer Res 2003; 9: 5532-9.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5532-5539
-
-
Onn, A.1
Isobe, T.2
Itasaka, S.3
-
25
-
-
33746442968
-
Hypoxia reduces the output of matrix metalloproteinase-9 (MMP-9) in monocytes by inhibiting its secretion and elevating membranal association
-
Rahat MA, Marom B, Bitterman H, Weiss-Cerem L, Kinarty A, Lahat N. Hypoxia reduces the output of matrix metalloproteinase-9 (MMP-9) in monocytes by inhibiting its secretion and elevating membranal association. J Leukoc Biol 2006; 79: 706-18.
-
(2006)
J Leukoc Biol
, vol.79
, pp. 706-718
-
-
Rahat, M.A.1
Marom, B.2
Bitterman, H.3
Weiss-Cerem, L.4
Kinarty, A.5
Lahat, N.6
-
26
-
-
16844362958
-
Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the 6β4 integrin
-
Yoon S-O, Shin S, Mercurio AM. Hypoxia stimulates carcinoma invasion by stabilizing microtubules and promoting the Rab11 trafficking of the 6β4 integrin. Cancer Res 2005; 65: 2761-9.
-
(2005)
Cancer Res
, vol.65
, pp. 2761-2769
-
-
Yoon, S.-O.1
Shin, S.2
Mercurio, A.M.3
-
27
-
-
0029328641
-
Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway
-
Woods CM, Zhu J, McQueney PA, Bollag D, Lazarides E. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol Med 1995; 1: 506-26.
-
(1995)
Mol Med
, vol.1
, pp. 506-526
-
-
Woods, C.M.1
Zhu, J.2
McQueney, P.A.3
Bollag, D.4
Lazarides, E.5
-
28
-
-
0028070358
-
Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telophase
-
Long BH, Fairchild CR. Paclitaxel inhibits progression of mitotic cells to G1 phase by interference with spindle formation without affecting other microtubule functions during anaphase and telophase. Cancer Res 1994; 54: 4355-61.
-
(1994)
Cancer Res
, vol.54
, pp. 4355-4361
-
-
Long, B.H.1
Fairchild, C.R.2
-
29
-
-
0031762622
-
Submicromolar paclitaxel induces apoptosis in human gastric cancer cells at early G1 phase
-
Lin HL, Chang YF, Liu TY, Wu CW, Chi CW. Submicromolar paclitaxel induces apoptosis in human gastric cancer cells at early G1 phase. Anticancer Res 1998; 18: 3443-9.
-
(1998)
Anticancer Res
, vol.18
, pp. 3443-3449
-
-
Lin, H.L.1
Chang, Y.F.2
Liu, T.Y.3
Wu, C.W.4
Chi, C.W.5
-
30
-
-
0029745777
-
Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel
-
Milross CG, Mason KA, Hunter NR, Chung WK, Peters LJ, Milas L. Relationship of mitotic arrest and apoptosis to antitumor effect of paclitaxel. J Natl Cancer Inst 1996; 88: 1308-14.
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 1308-1314
-
-
Milross, C.G.1
Mason, K.A.2
Hunter, N.R.3
Chung, W.K.4
Peters, L.J.5
Milas, L.6
-
31
-
-
0028906559
-
Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with Taxol
-
Milas L, Hunter NR, Kurdoglu B et al. Kinetics of mitotic arrest and apoptosis in murine mammary and ovarian tumors treated with Taxol. Cancer Chemother Pharmacol 1995; 35: 297-303.
-
(1995)
Cancer Chemother Pharmacol
, vol.35
, pp. 297-303
-
-
Milas, L.1
Hunter, N.R.2
Kurdoglu, B.3
-
32
-
-
0030886975
-
p53-independent apoptosis induced by paclitaxel through an indirect mechanism
-
Lanni JS, Lowe SW, Licitra EJ, Liu JO, Jacks T. p53-independent apoptosis induced by paclitaxel through an indirect mechanism. Proc Natl Acad Sci USA 1997; 94: 9679-83.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9679-9683
-
-
Lanni, J.S.1
Lowe, S.W.2
Licitra, E.J.3
Liu, J.O.4
Jacks, T.5
-
33
-
-
0032584126
-
Taxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis
-
Moos PJ, Fitzpatrick FA. Taxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis. Proc Natl Acad Sci USA 1998; 95: 3896-901.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 3896-3901
-
-
Moos, P.J.1
Fitzpatrick, F.A.2
-
34
-
-
0031036307
-
Raf-1/bcl-2 phosphorylation: A step from microtubule damage to cell death
-
Blagosklonny MV, Giannakakou P, el-Deiry WS, et al. Raf-1/bcl-2 phosphorylation: A step from microtubule damage to cell death. Cancer Res 1997; 57: 130-5.
-
(1997)
Cancer Res
, vol.57
, pp. 130-135
-
-
Blagosklonny, M.V.1
Giannakakou, P.2
el-Deiry, W.S.3
-
36
-
-
0007572494
-
Mode of action of Taxol and characterization of multidrug-resistant cell line resistant to Taxol
-
In: Kessel D, ed. Boca Raton, FL: CRC Press
-
Horwitz SB, Liao LL, Greenberger L, et al. Mode of action of Taxol and characterization of multidrug-resistant cell line resistant to Taxol. In: Kessel D, ed. Resistance to Antineoplastic Drugs. Boca Raton, FL: CRC Press, 1989; 109-26.
-
(1989)
Resistance to Antineoplastic Drugs
, pp. 109-126
-
-
Horwitz, S.B.1
Liao, L.L.2
Greenberger, L.3
-
37
-
-
23844521998
-
P-glycoprotein-implications of metabolism of neoplastic cells and cancer therapy
-
Breier A, Barancik M, Sulova Z, Uhrik B. P-glycoprotein-implications of metabolism of neoplastic cells and cancer therapy. Curr Cancer Drug Targets 2005; 5: 457-68.
-
(2005)
Curr Cancer Drug Targets
, vol.5
, pp. 457-468
-
-
Breier, A.1
Barancik, M.2
Sulova, Z.3
Uhrik, B.4
-
38
-
-
0030450845
-
Double knockout of the MRP gene leads to increased drug sensitivity in vitro
-
Lorico A, Rappa G, Flavell RA, et al. Double knockout of the MRP gene leads to increased drug sensitivity in vitro. Cancer Res 1996; 56: 5351-5.
-
(1996)
Cancer Res
, vol.56
, pp. 5351-5355
-
-
Lorico, A.1
Rappa, G.2
Flavell, R.A.3
-
39
-
-
0033954247
-
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1a
-
Ravi R, Mookerjee B, Bhujwalla ZM, et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1a. Gene Dev 2000; 14: 34-44.
-
(2000)
Gene Dev
, vol.14
, pp. 34-44
-
-
Ravi, R.1
Mookerjee, B.2
Bhujwalla, Z.M.3
-
40
-
-
0036678830
-
Two sequence motifs from HIF-1 alpha bind to the DNA-binding site of p53
-
Hansson LO, Friedler A, Freund S, et al. Two sequence motifs from HIF-1 alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci USA 2002; 99: 10 305-9.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
-
-
Hansson, L.O.1
Friedler, A.2
Freund, S.3
-
41
-
-
0038529602
-
Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
-
Chen D, Li M, Luo J, et al. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem 2003; 278: 13 595-8.
-
(2003)
J Biol Chem
, vol.278
-
-
Chen, D.1
Li, M.2
Luo, J.3
-
42
-
-
0032568150
-
Stabilization of wild-type p53 by hypoxia-inducible factor 1 alpha
-
An WG, Kanekal M, Simon MC, et al. Stabilization of wild-type p53 by hypoxia-inducible factor 1 alpha. Nature 1998; 392: 405-8.
-
(1998)
Nature
, vol.392
, pp. 405-408
-
-
An, W.G.1
Kanekal, M.2
Simon, M.C.3
-
43
-
-
0033957264
-
p53 Gene status modulates the chemosensitivity of non-small cell lung cancer cells
-
Lai S-L, Perng R-P, Hwang J. p53 Gene status modulates the chemosensitivity of non-small cell lung cancer cells. J Biomed Sci 2000; 7: 64-70.
-
(2000)
J Biomed Sci
, vol.7
, pp. 64-70
-
-
Lai, S.-L.1
Perng, R.-P.2
Hwang, J.3
-
44
-
-
0038219598
-
Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry
-
Verdier-Pinard P, Wang F, Martello L, Burd B, Orr GA, Horwitz SB. Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry. Biochemistry 2003; 42: 5349-57.
-
(2003)
Biochemistry
, vol.42
, pp. 5349-5357
-
-
Verdier-Pinard, P.1
Wang, F.2
Martello, L.3
Burd, B.4
Orr, G.A.5
Horwitz, S.B.6
-
45
-
-
0035060238
-
Factors determining cellular mechanisms of resistance to antimitotic drugs
-
Cabral F. Factors determining cellular mechanisms of resistance to antimitotic drugs. Drug Resist Updat 2001; 4: 3-8.
-
(2001)
Drug Resist Updat
, vol.4
, pp. 3-8
-
-
Cabral, F.1
-
46
-
-
0032006059
-
Microtubules and actin filaments: Dynamic targets for cancer chemotherapy
-
Jordan MA, Wilson L. Microtubules and actin filaments: Dynamic targets for cancer chemotherapy. Curr Opin Cell Biol 1998; 10: 123-30.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 123-130
-
-
Jordan, M.A.1
Wilson, L.2
|