Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age

Human Molecular Genetics

Volumn 16, Issue 14, 2007, Pages 1708-1719

  Lambourne, Sarah L ^a   Humby, Trevor ^a,b,c   Isles, Anthony R ^a,b,c   Emson, Piers C ^a   Spillantini, Maria G ^d   Wilkinson, Lawrence S ^a,b,c  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TAU PROTEIN;

AGING; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 17; COGNITION; CONTROLLED STUDY; DISEASE EXACERBATION; FRONTOTEMPORAL DEMENTIA; GENE EXPRESSION; GENE MUTATION; IMPULSIVENESS; LONGITUDINAL STUDY; MOTIVATION; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENSORIMOTOR FUNCTION; TASK PERFORMANCE; TRANSGENIC MOUSE;

AGE FACTORS; AGING; ANIMALS; BRAIN; CHROMOSOMES, HUMAN, PAIR 17; DEMENTIA; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; HUMANS; IMPULSE CONTROL DISORDERS; MICE; MICE, TRANSGENIC; MUTATION; SPINAL CORD; TAU PROTEINS; TIME FACTORS;

MURINAE; MUS; MUS MUSCULUS;

EID: 34547775838     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddm119     Document Type: Article

References (46)

1. Ingram, E.M. and Spillantini, M.G. (2002) Tau gene mutations: Dissecting the pathogenesis of FTDP-17. Trends Mol. Med., 8, 555-562.
2. Gotz, J., Tolnay, M., Barmettler, R., Chen, F., Probst, A. and Nitsch, R.M. (2001) Oligodendroglial tau filament formation in transgenic mice expressing G272V tau. Eur. J. Neurosci., 13, 2131-2140.
3. Gotz, J., Chen, F., Barmettler, R. and Nitsch, R.M. (2001) Tau filament formation in transgenic mice expressing P301L tau. J. Biol. Chem., 276, 529-534.
4. Lewis, J., McGowan, E., Rockwood, J., Melrose, H., Nacharaju, P., Van Slegtenhorst, M., Gwinn-Hardy, K., Paul Murphy, M., Baker, M., Yu, X. et al. (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat. Genet., 25, 402-405.
5. Allen, B., Ingram, E., Takao, M., Smith, M.J., Jakes, R., Virdee, K., Yoshida, H., Holzer, M., Craxton, M., Emson, P.C. et al. (2002) Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J. Neurosci., 22, 9340-9351.
6. Tanemura, K., Akagi, T., Murayama, M., Kikuchi, N., Murayama, O., Hashikawa, T., Yoshiike, Y., Park, J.M., Matsuda, K., Nakao, S. et al. (2001) Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiol. Dis., 8, 1036-1045.
7. Tanemura, K., Murayama, M., Akagi, T., Hashikawa, T., Tominaga, T., Ichikawa, M., Yamaguchi, H. and Takashima, A. (2002) Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J. Neurosci., 22, 133-141.
8. Tatebayashi, Y., Miyasaka, T., Chui, D.H., Akagi, T., Mishima, K., Iwasaki, K., Fujiwara, M., Tanemura, K., Murayama, M., Ishiguro, K. et al. (2002) Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc. Natl Acad. Sci. USA, 99, 13896-13901.
9. Poorkaj, P., Bird, T.D., Wijsman, E., Nemens, E., Garruto, R.M., Anderson, L., Andreadis, A., Wiederholt, W.C., Raskind, M. and Schellenberg, G.D. (1998) Tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann. Neurol., 43, 815-825.
10. Sumi, S.M., Bird, T.D., Nochlin, D. and Raskind, M.A. (1992) Familial presenile dementia with psychosis associated with cortical neurofibrillary tangles and degeneration of the amygdala. Neurology 42, 120-127.
11. Bozeat, S., Gregory, C.A., Ralph, M.A. and Hodges, J.R. (2000) Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? J. Neurol. Neurosurg. Psychiatry, 69, 178-186.
12. Plaisted, K. and Sahakian, B. (1997) Dementia of frontal type - living in the here and now. Aging Ment. Health, 1, 293-295.
13. Rahman, S., Sahakian, B.J., Hodges, J.R., Rogers, R.D. and Robbins, T.W. (1999) Specific cognitive deficits in mild frontal variant frontotemporal dementia. Brain, 122, 1469-1493.
14. Sieroff, E., Piquard, A., Auclair, L., Lacomblez, L., Derouesne, C. and Laberge, D. (2004) Deficit of preparatory attention in frontotemporal dementia. Brain Cogn., 55, 444-451.
15. Lambourne, S.L., Sellers, L.A., Bush, T.G., Choudhury, S.K., Emson, P.C., Suh, Y.H. and Wilkinson, L.S. (2005) Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities. Mol. Cell. Biol., 25, 278-293.
16. Humby, T., Laird, F.M., Davies, W. and Wilkinson, L.S. (1999) Visuospatial attentional functioning in mice: Interactions between cholinergic manipulations and genotype. Eur. J. Neurosci., 11 2813-2823.
17. Robbins, T.W. (2002) The 5-choice serial reaction time task: Behavioural pharmacology and functional neurochemistry. Psychopharmacology (Berl.), 163, 362-380.
18. Davies, W., Humby, T., Isles, A.R., Burgoyne, P.S. and Wilkinson, L.S. (2006) X-monosomy effects on visuospatial attention in mice: A candidate gene and implications for Turner syndrome and attention deficit hyperactivity disorder. Biol. Psychiatry, doi:10.1016/ j.biopsych.2006.08.11.
19. Humby, T., Wilkinson, L.S. and Dawson, G.R. (2005) Assaying aspects of attention and impulse control in mice using the 5-choice serial reaction time task. Current Protocols in Neuroscience, John Wiley & Sons, Unit 8.5H.
20. Wilkinson, R.T. (1963) Interaction of noise with knowledge of results and sleep deprivation. J. Exp. Psychol., 66, 332-337.
21. Robbins, T.W., James, M., Owen, A.M., Sahakian, B.J., Lawrence, A.D., McInnes, L. and Rabbitt, P.M. (1998) A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: Implications for theories of executive functioning and cognitive aging. Cambridge neuropsychological test automated battery. J. Int. Neuropsychol. Soc., 4, 474-490.
22. Robbins, T.W., James, M., Owen, A.M., Sahakian, B.J., McInnes, L. and Rabbitt, P. (1994) Cambridge Neuropsychological Test Automated Battery (CANTAB): A factor analytic study of a large sample of normal elderly volunteers. Dementia, 5, 266-281.
23. Sahakian, B.J. and Coull, J.T. (1993) Tetrahydroaminoacridine (THA) in Alzheimer's disease: An assessment of attentional and mnemonic function using CANTAB. Acta Neurol. Scand. Suppl., 149, 29-35.
24. Young, J.W., Finlayson, K., Spratt, C., Marston, H.M., Crawford, N., Kelly, J.S. and Sharkey, J. (2004) Nicotine improves sustained attention in mice: Evidence for involvement of the alpha7 nicotinic acetylcholine receptor. Neuropsychopharmacology, 29, 891-900.
25. Reed, L.A., Wszolek, Z.K. and Hutton, M. (2001) Phenotypic correlations in FTDP-17. Neurobiol. Aging, 22, 89-107.
26. Wszolek, Z.K., Tsuboi, Y., Ghetti, B., Pickering-Brown, S., Baba, Y. and Cheshire, W.P. (2006) Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Orphanet J. Rare Dis., 1, 30.
27. Evenden, J. (1999) Impulsivity: A discussion of clinical and experimental findings. J. Psychopharmacol., 13, 180-192.
28. Patel, S., Stolerman, I.P., Asherson, P. and Sluyter, F. (2006) Attentional performance of C57BL/6 and DBA/2 mice in the 5-choice serial reaction time task. Behav. Brain Res., 170, 197-203.
29. Evenden, J.L. (1999) Varieties of impulsivity. Psychopharmacology (Berl.), 146, 348-361.
30. Aron, A.R., Dowson, J.H., Sahakian, B.J. and Robbins, T.W. (2003) Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder. Biol. Psychiatry, 54 1465-1468.
31. Bellgrove, M.A., Chambers, C.D., Vance, A., Hall, N., Karamitsios, M. and Bradshaw, J.L. (2006) Lateralized deficit of response inhibition in early-onset schizophrenia. Psychol. Med., 36, 495-505.
32. Schmidtke, K., Schorb, A., Winkelmann, G. and Hohagen, F. (1998) Cognitive frontal lobe dysfunction in obsessive-compulsive disorder. Biol. Psychiatry, 43, 666-673.
33. Muir, J.L., Everitt, B.J. and Robbins, T.W. (1996) The cerebral cortex of the rat and visual attentional function: Dissociable effects of mediofrontal, cingulate, anterior dorsolateral, and parietal cortex lesions on a five-choice serial reaction time task. Cereb. Cortex, 6, 470-481.
34. Chudasama, Y., Passetti, F., Rhodes, S.E., Lopian, D., Desai, A. and Robbins, T.W. (2003) Dissociable aspects of performance on the 5-choice serial reaction time task following lesions of the dorsal anterior cingulate, infralimbic and orbitofrontal cortex in the rat: Differential effects on selectivity, impulsivity and compulsivity. Behav. Brain Res., 146, 105-119.
35. Christakou, A., Robbins, T.W. and Everitt, B.J. (2004) Prefrontal cortical-ventral striatal interactions involved in affective modulation of attentional performance: Implications for corticostriatal circuit function. J. Neurosci., 24, 773-780.
36. Millan, M.J. (2003) The neurobiology and control of anxious states. Prog. Neurobiol., 70, 83-244.
37. Egashira, N., Iwasaki, K., Takashima, A., Watanabe, T., Kawabe, H., Matsuda, T., Mishima, K., Chidori, S., Nishimura, R. and Fujiwara, M. (2005) Altered depression-related behavior and neurochemical changes in serotonergic neurons in mutant R406W human tau transgenic mice. Brain Res., 1059, 7-12.
38. Lebert, F., Stekke, W., Hasenbroekx, C. and Pasquier, F. (2004) Frontotemporal dementia: A randomised, controlled trial with trazodone. Dement. Geriatr. Cogn. Disord., 17, 355-359.
39. Moretti, R., Torre, P., Antonello, R.M., Cazzato, G. and Bava, A. (2003) Frontotemporal dementia: Paroxetine as a possible treatment of behavior symptoms. A randomized, controlled, open 14-month study. Eur. Neurol. 49, 13-19.
40. Deakin, J.B., Rahman, S., Nestor, P.J., Hodges, J.R. and Sahakian, B.J. (2004) Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: A double-blind randomized controlled trial. Psychopharmacology (Berl.), 172, 400-408.
41. Ferman, T.J., McRae, C.A., Arvanitakis, Z., Tsuboi, Y., Vo, A. and Wszolek, Z.K. (2003) Early and pre-symptomatic neuropsychological dysfunction in the PPND family with the N279K tau mutation. Parkinsonism Relat. Disord., 9, 265-270.
42. Isles, A.R., Humby, T., Walters, E. and Wilkinson, L.S. (2004) Common genetic effects on variation in impulsivity and activity in mice. J. Neurosci., 24, 6733-6740.
43. Isles, A.R., Humby, T. and Wilkinson, L.S. (2003) Measuring impulsivity in mice using a novel operant delayed reinforcement task: Effects of behavioural manipulations and d-amphetamine. Psychopharmacology (Berl.), 170, 376-382.
44. Greenberg, S.G., Davies, P. (1990) A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis. Proc Natl Acad Sci USA, 87, 5827-5831.
45. Carter, R.J., Lione, L.A., Humby, T., Mangiarini, L., Mahal, A., Bates, G.P., Dunnett, S.B. and Morton, A.J. (1999) Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation. J. Neurosci., 19, 3248-3257.
46. Hogg, R.V. and Craig, A. (1995) Introduction to Mathematical Statistics, 5th edn. Prentice-Hall, Boston, Massachusetts, USA.