Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: A double-blind randomized controlled trial

Psychopharmacology

Volumn 172, Issue 4, 2004, Pages 400-408

  Deakin, J B ^a   Rahman, S ^a   Nestor, P J ^b   Hodges, J R ^b   Sahakian, B J ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Decision making; Frontotemporal dementia; Paroxetine; Serotonin

Indexed keywords

PAROXETINE; PLACEBO; SEROTONIN UPTAKE INHIBITOR;

ADULT; AGED; APTITUDE TEST; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DECISION MAKING; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; FRONTOTEMPORAL DEMENTIA; GENERAL CONDITION IMPROVEMENT; HUMAN; INTELLIGENCE; LEARNING; MALE; MENTAL TASK; NEUROPSYCHIATRY; NEUROPSYCHOLOGICAL TEST; PAIRED ASSOCIATE LEARNING; PATTERN RECOGNITION; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; PSYCHOLOGICAL ASPECT; RANDOMIZED CONTROLLED TRIAL; RECOGNITION; SPATIAL MEMORY; TREATMENT FAILURE; VISUAL DISCRIMINATION;

AGED; ASSOCIATION LEARNING; ATTENTION; COGNITION; DEMENTIA; DOUBLE-BLIND METHOD; FEMALE; FRONTAL LOBE; HUMANS; MALE; MEMORY; MIDDLE AGED; PAROXETINE; PSYCHIATRIC STATUS RATING SCALES; QUESTIONNAIRES; REACTION TIME; RISK-TAKING; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS; VISUAL PERCEPTION;

EID: 2442492769     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-003-1686-5     Document Type: Article

References (41)

1. Bechara A, Damasio H, Damasio AR, Lee GP (1999) Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making. J Neurosci 19:5473-5481
2. Benton AL (1968) Differential behavioural effects in frontal lobe disease. Neuropsychologia 6:53-60
3. Blier P, de Montigny C (1998) Possible serotonergic mechanisms underlying the antidepressant and anti-obsessive-compulsive disorder responses. Biol Psychiatry 44:313-323
4. Blier P, de Montigny C (1999) Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology 21:91S-98S
5. Bozeat S, Gregory CA, Ralph MA, Hodges JR (2000) Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer's disease? J Neurol Neurosurg Psychiatry 69:178-186
6. Cummings JL, Mega M, Gray K, Rosenberg-Thompson S, Carusi DA, Gornbein J (1994) The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology 44:2308-2314
7. Dolan M, Anderson IM, Deakin JF (2001) Relationship between 5-HT function and impulsivity and aggression in male offenders with personality disorders. Br J Psychiatry 178:352-359
8. Downes JJ, Roberts AC, Sahakian BJ, Evenden JL, Morris RG, Robbins TW (1989) Impaired extra-dimensional shift performance in medicated and unmedicated Parkinson's disease: evidence for a specific attentional dysfunction. Neuropsychologia 27:1329-1343
9. Elliott R, Sahakian BJ, Matthews K, Bannerjea A, Rimmer J, Robbins TW (1997) Effects of methylphenidate on spatial working memory and planning in healthy young adults. Psychopharmacology 131:196-206
10. Fowler KS, Saling MM, Conway EL, Semple JM, Louis WJ (1995) Computerized delayed matching to sample and paired associate performance in the early detection of dementia. Appl Neuropsychol 2:72-78
11. Gregory CA (1999) Frontal variant of frontotemporal dementia: a cross-sectional and longitudinal study of neuropsychiatric features. Psychol Med 29:1205-1217
12. Gregory CA, Serra-Mestres J, Hodges JR (1999) Early diagnosis of the frontal variant of frontotemporal dementia: how sensitive are standard neuroimaging and neuropsychologic tests? Neuropsychiatry Neuropsychol Behav Neurol 12:128-135
13. Grundman M, Corey-Bloom J, Thal LJ (1998) Perspectives in clinical Alzheimer's disease research and the development of antidementia drugs. J Neural Transm Suppl 53:255-275
14. Hodges JR, Miller B (2001) The classification, genetics and neuropathology of frontotemporal dementia. Introduction to the special topic papers: part I. Neurocase 7:31-35
15. Joyce EM, Robbins TW (1991) Frontal lobe function in Korsakoff and non-Korsakoff alcoholics: planning and spatial working memory. Neuropsychologia 29:709-723
16. Levy ML, Miller BL, Cummings JL, Fairbanks LA, Craig A (1996) Alzheimer disease and frontotemporal dementias. Behavioral distinctions. Arch Neurol 53:687-690
17. Manes F, Sahakian B, Clark L, Rogers R, Aitken M, Robbins T (2002) Decision-making processes following damage to the prefrontal cortex. Brain 125:624-639
18. Mann JJ (1999) Role of the serotonergic system in the pathogenesis of major depression and suicidal behavior. Neuropsychopharmacology 21:99S-105S
19. Mavaddat N, Kirkpatrick PJ, Rogers RD, Sahakian BJ (2000) Deficits in decision-making in patients with aneurysms of the anterior communicating artery. Brain 123:2109-2117
20. McKeith I, Del Ser T, Spano P, Emre M, Wesnes K, Anand R, Cicin-Sain A, Ferrara R, Spiegel R (2000) Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. Lancet 356:2031-2036
21. Milner B (1964) Effects of different brain lesions on card sorting. Arch Neurol 9:100-110
22. Montgomery SA (1996) Long-term management of obsessive-compulsive disorder. Int Clin Psychopharmacol 11[Suppl 5]:23-29
23. Moretti R, Torre P, Antonello RM, Cazzato G, Bava A (2003) Frontotemporal dementia: paroxetine as a possible treatment of behavior symptoms. A randomized, controlled, open 14-month study. Eur Neurol 49:13-19
24. Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF (1998) Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology 51:1546-1554
25. Neary D, Snowden JS, Mann DM (2000) Classification and description of frontotemporal dementias. Ann New York Acad Sci 920:46-51
26. Orrell MW, Sahakian BJ (1991) Dementia of frontal lobe type (editorial). Psychol Med 21:553-556
27. Owen AM, Downes JJ, Sahakian BJ, Polkey CE, Robbins TW (1990) Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28:1021-1034
28. Park SB, Coull JT, McShane RH, Young AH, Sahakian BJ, Robbins TW, Cowen PJ (1994) Tryptophan depletion in normal volunteers produces selective impairments in learning and memory. Neuropharmacology 33:575-588
29. Perry RJ, Hodges JR (1999) Attention and executive deficits in Alzheimer's disease. A critical review. Brain 122:383-404
30. Plaisted KC, Sahakian BJ (1997) Dementia of the frontal lobe type-living in the here and now. Aging Mental Health 1:293-295
31. Rahman S, Sahakian BJ, Hodges JR, Rogers RD, Robbins TW (1999) Specific cognitive deficits in mild frontal variant frontotemporal dementia. Brain 122:1469-1493
32. Ratnavalli E, Brayne C, Dawson K, Hodges JR (2002) The prevalence of frontotemporal dementia. Neurology 58:1615-1621
33. Robbins TW (2000) Chemical neuromodulation of frontal-executive functions in humans and other animals. Exp Brain Res 133:130-138
34. Rogers RD, Robbins TW (2001) Investigating the neurocognitive deficits associated with chronic drug misuse. Curr Opin Neurobiol 11:250-257
35. Rogers RD, Blackshaw AJ, Middleton HC, Matthews K, Hawtin K, Crowley C, Hopwood A, Wallace C, Deakin JF, Sahakian BJ, Robbins TW (1999a) Tryptophan depletion impairs stimulus-reward learning while methylphenidate disrupts attentional control in healthy young adults: implications for the monoaminergic basis of impulsive behaviour. Psychopharmacology 146:482-491
36. Rogers RD, Everitt BJ, Baldacchino A, Blackshaw AJ, Swainson R, Wynne K, Baker NB, Hunter J, Carthy T, Booker E, London M, Deakin JF, Sahakian BJ, Robbins TW (1999b) Dissociable deficits in the decision-making cognition of chronic amphetamine abusers, opiate abusers, patients with focal damage to prefrontal cortex, and tryptophan-depleted normal volunteers: evidence for monoaminergic mechanisms. Neuropsychopharmacology 20:322-339
37. Rubinsztein JS, Rogers RD, Riedel WJ, Mehta MA, Robbins TW, Sahakian BJ (2001) Acute dietary tryptophan depletion impairs maintenance of "affective set" and delayed visual recognition in healthy volunteers. Psychopharmacology 154:319-326
38. Sahakian BJ, Morris RG, Evenden JL, Heald A, Levy R, Philpot M, Robbins TW (1988) A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain 111:695-718
39. Smith TD, Kuczenski R, George-Friedman K, Malley JD, Foote SL (2000) In vivo microdialysis assessment of extracellular serotonin and dopamine levels in awake monkeys during sustained fluoxetine administration. Synapse 38:460-470
40. Sparks DL, Markesbery WR (1991) Altered serotonergic and cholinergic synaptic markers in Pick's disease. Arch Neurol 48:796-799
41. Swartz JR, Miller BL, Lesser IM, Darby AL (1997) Frontotemporal dementia: treatment response to serotonin selective reuptake inhibitors. J Clin Psychiatry 58:212-216