Human monoclonal antibodies against the complex of phosphatidylserine and prothrombin from patients with the antiphospholipid antibodies

Lupus

Volumn 16, Issue 7, 2007, Pages 509-516

  Horita, Tetsuya ^a   Ichikawa, K ^a   Kataoka, H ^a   Yasuda, S ^a   Atsumi, T ^a   Koike, T ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Antiphospholipid antibodies; Lupus anticoagulant; Monoclonal antibody; Prothrombin; Systemic lupus erythematosus

Indexed keywords

CARDIOLIPIN; EPITOPE; LUPUS ANTICOAGULANT; MONOCLONAL ANTIBODY; PHOSPHATIDYLSERINE; PHOSPHOLIPID ANTIBODY; POLYSTYRENE; PROTHROMBIN;

ADULT; AGED; ANTIGEN BINDING; ARTICLE; AUTOIMMUNITY; CASE REPORT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MALE; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS;

AGED; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, MONOCLONAL; AUTOIMMUNITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULIN M; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; PHOSPHATIDYLSERINES; PROGNOSIS; PROTHROMBIN; SEVERITY OF ILLNESS INDEX;

EID: 34547766545     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203307078680     Document Type: Article

References (43)

1. Hughes GR. The antiphospholipid syndrome: ten years on. Lancet 1993; 342(8867): 341-344.
2. Khamashta MA, Hughes GR. Antiphospholipid antibodies and antiphospholipid syndrome. Curr Opin Rheumatol 1995; 7(5): 389-394.
3. Galli M, Comfurius P, Maassen C et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 1990; 335(8705): 1544-1547.
4. Matsuura E, Igarashi Y, Fujimoto M, Ichikawa K, Koike T. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 1990; 336(8708): 177-178.
5. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 1990; 87(11): 4120-4124.
6. Roubey RA. Immunology of the antiphospholipid antibody syndrome. Arthritis Rheum 1996; 39(9): 1444-1454.
7. Matsuura E, Igarashi Y, Yasuda T, Triplett DA, Koike T. Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J Exp Med 1994; 179(2): 457-462.
8. Oosting JD, Derksen R, Entjes H, Bouma B, de Groot P. Lupus anticoagulant activity is frequently dependent on the presence of beta-2 glycoprotein I. Thromb Haemost 1992; 67: 499-502.
9. Ichikawa K, Khamashta MA, Koike T, Matsuura E, Hughes GR. beta 2-Glycoprotein I reactivity of monoclonal anticardiolipin antibodies from patients with the antiphospholipid syndrome. Arthritis Rheum 1994; 37(10): 1453-1461.
10. Takeya H, Mori T, Gabazza EC et al. Anti-beta2-glycoprotein I (beta2GPI) monoclonal antibodies with lupus anticoagulant-like activity enhance the beta2GPI binding to phospholipids. J Clin Invest 1997; 99(9): 2260-2268.
11. Löliger A. Prothrombin as a co-factor of the circulating anticoagulant in systemic lupus erythematosus? Thromb Diath Haemorrh 1959; 3: 237-256.
12. Galli M, Barbui T. Antiprothrombin antibodies: detection and clinical significance in the antiphospholipid syndrome. Blood 1999; 93(7): 2149-2157.
13. Wu JR, Lentz BR. Phospholipid-specific conformational changes in human prothrombin upon binding to procoagulant acidic lipid membranes. Thromb Haemost 1994; 71(5): 596-604.
14. Krishnaswamy S, Church WR, Nesheim ME, Mann KG. Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism. J Biol Chem 1987; 262(7): 3291-3299.
15. Puurunen M, Vaarala O, Julkunen H, Aho K, Palosuo T. Antibodies to phospholipid-binding plasma proteins and occurrence of thrombosis in patients with systemic lupus erythematosus. Clin Immunol Immunopathol 1996; 80(1): 16-22.
16. Sorice M, Pittoni V, Circella A et al. Anti-prothrombin but not "pure" anti-cardiolipin antibodies are associated with the clinical features of the antiphospholipid antibody syndrome. Thromb Haemost 1998; 80(4): 713-715.
17. Bertolaccini ML, Atsumi T, Khamashta MA, Amengual O, Hughes GR. Autoantibodies to human prothrombin and clinical manifestations in 207 patients with systemic lupus erythematosus. J Rheumatol 1998; 25(6): 1104-1108.
18. Pengo V, Biasiolo A, Brocco T, Tonetto S, Ruffatti A. Autoantibodies to phospholipid-binding plasma proteins in patients with thrombosis and phospholipid-reactive antibodies. Thromb Haemost 1996; 75(5): 721-724.
19. Horbach DA, van Oort E, Donders RC, Derksen RH, de Groot PG. Lupus anticoagulant is the strongest risk factor for both venous and arterial thrombosis in patients with systemic lupus erythematosus. Comparison between different assays for the detection of antiphospholipid antibodies. Thromb Haemost 1996; 76(6): 916-924.
20. Forastiero RR, Martinuzzo ME, Cerrato GS, Kordich LC, Carreras LO. Relationship of anti beta2-glycoprotein I and anti prothrombin antibodies to thrombosis and pregnancy loss in patients with antiphospholipid antibodies. Thromb Haemost 1997; 78(3): 1008-1014.
21. Swadzba J, De Clerck LS, Stevens WJ et al. Anticardiolipin, anti-beta(2)-glycoprotein I, antiprothrombin antibodies, and lupus anticoagulant in patients with systemic lupus erythematosus with a history of thrombosis. J Rheumatol 1997; 24(9): 1710-1715.
22. Guerin J, Smith O, White B, Sweetman G, Feighery C, Jackson J. Antibodies to prothrombin in antiphospholipid syndrome and inflammatory disorders. Br J Haematol 1998; 102(4): 896-902.
23. Fleck RA, Rapaport SI, Rao LV. Anti-prothrombin antibodies and the lupus anticoagulant. Blood 1988; 72(2): 512-519.
24. Arvieux J, Darnige L, Caron C, Reber G, Bensa JC, Colomb MG. Development of an ELISA for autoantibodies to prothrombin showing their prevalence in patients with lupus anticoagulants. Thromb Haemost 1995; 74(4): 1120-1125.
25. Galli M, Beretta G, Daldossi M, Bevers EM, Barbui T. Different anticoagulant and immunological properties of anti-prothrombin antibodies in patients with antiphospholipid antibodies. Thromb Haemost 1997; 77(3): 486-491.
26. Atsumi T, Ieko M, Bertolaccini ML et al. Association of autoantibodies against the phosphatidylserine-prothrombin complex with manifestations of the antiphospholipid syndrome and with the presence of lupus anticoagulant. Arthritis Rheum 2000; 43(9): 1982-1993.
27. Amengual O, Atsumi T, Koike T. Specificities, properties, and clinical significance of antiprothrombin antibodies. Arthritis Rheum 2003; 48(4): 886-895.
28. Amengual O, Atsumi T, Koike T. Antiprothrombin antibodies and the diagnosis of antiphospholipid syndrome. Clin Immunol 2004; 112(2): 144-149.
29. D'Agnillo P, Levine JS, Subang R, Rauch J. Prothrombin binds to the surface of apoptotic, but not viable, cells and serves as a target of lupus anticoagulant autoantibodies. J Immunol 2003; 170(6): 3408-3422.
30. Rauch J, D'Agnillo P, Subang R, Levine JS. Anti-phospholipid antibodies (aPL) and apoptosis: prothrombin-dependent aPL as a paradigm for phospholipid-dependent interactions with apoptotic cells. Thromb Res 2004; 114(5-6): 371-382.
31. Miyakis S, Lockshin MD, Atsumi T et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4(2): 295-306.
32. Roubey RA, Eisenberg RA, Harper MF, Winfield JB. " Anticardiolipin" autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding. J Immunol 1995; 154(2): 954-960.
33. Rao LV, Hoang AD, Rapaport SI. Mechanism and effects of the binding of lupus anticoagulant IgG and prothrombin to surface phospholipid. Blood 1996; 88(11): 4173-4182.
34. Akimoto T, Akama T, Kono I, Sumida T. Relationship between clinical features and binding domains of anti-prothrombin autoantibodies in patients with systemic lupus erythematosus and antiphospholipid syndrome. Lupus 1999; 8(9): 761-766.
35. Bevers EM, Galli M, Barbui T, Comfurius P, Zwaal RF. Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin. Thromb Haemost 1991; 66(6): 629-632.
36. Oosting JD, Derksen RH, Bobbink IW, Hackeng TM, Bouma BN, de Groot PG. Antiphospholipid antibodies directed against a combination of phospholipids with prothrombin, protein C, or protein S: an explanation for their pathogenic mechanism? Blood 1993; 81(10): 2618-2625.
37. Field SL, Hogg PJ, Daly EB et al. Lupus anticoagulants form immune complexes with prothrombin and phospholipid that can augment thrombin production in flow. Blood 1999; 94(10): 3421-3431.
38. Field SL, Chesterman CN, Dai YP, Hogg PJ. Lupus antibody bivalency is required to enhance prothrombin binding to phospholipid. J Immunol 2001; 166(10): 6118-6125.
39. Willems GM, Janssen MP, Comfurius P, Galli M, Zwaal RF, Bevers EM. Kinetics of prothrombin-mediated binding of lupus anticoagulant antibodies to phosphatidylserine-containing phospholipid membranes: an ellipsometric study. Biochemistry 2002; 41(48): 14357-14363.
40. Horbach DA, van Oort E, Derksen RH, de Groot PG. The contribution of anti-prothrombin-antibodies to lupus anticoagulant activity - discrimination between functional and non-functional anti-prothrombin-antibodies. Thromb Haemost 1998; 79(4): 790-795.
41. Zhao Y, Rumold R, Zhu M et al. An IgG antiprothrombin antibody enhances prothrombin binding to damaged endothelial cells and shortens plasma coagulation times. Arthritis Rheum 1999; 42(10): 2132-2138.
42. Roubey RA, Pratt CW, Buyon JP, Winfield JB. Lupus anticoagulant activity of autoimmune antiphospholipid antibodies is dependent upon beta 2-glycoprotein I. J Clin Invest 1992; 90(3): 1100-1104.
43. Arnout J, Vanrusselt M, Wittevrongel C, Vermylen J. Monoclonal antibodies against beta-2-glycoprotein I: use as reference material for lupus anticoagulant tests. Thromb Haemost 1998; 79(5): 955-958.