Lupus antibody bivalency is required to enhance prothrombin binding to phospholipid

Journal of Immunology

Volumn 166, Issue 10, 2001, Pages 6118-6125

  Field, Susan L ^a   Chesterman, Colin N ^a,b   Dai, Yan Ping ^a   Hogg, Philip J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LUPUS ANTICOAGULANT; MONOCLONAL ANTIBODY; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID; PROTHROMBIN;

ARTICLE; BLOOD VESSEL WALL; CELL VACUOLE; CONTROLLED STUDY; HUMAN; MOLECULAR MODEL; PHOSPHOLIPID VESICLE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN INTERACTION;

EID: 0035873773     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.10.6118     Document Type: Article

References (28)

1. Brighton, T. A., and C. N. Chesterman. 1994. Antiphospholipid antibodies and thrombosis. Bailliére's Clin. Haematol. 7:541.
2. Galli, M., P. Comfurius, C. Maassen, H. C. Hemker, M. H. de Baets, P. J. C. van Breda-Vriesman, T. Barbui, R. F. A. Zwaal, and E. M. Bevers. 1990. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 335:1544.
3. 2-glycoprotein I (apolipoprotein H). Proc. Natl. Acad. Sci. USA 87:4120.
4. Bevers, E. M., M. Galli, T. Barbui, P. Comfurius, and R. F. A. Zwaal. 1991. Lupus anticoagulant IgGs (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin. Thromb. Haemost. 66:629.
5. 2-glycoprotein I. J. Clin. Invest. 90:1100.
6. Galli, M., G. Beretta, M. Daldossi, E. M. Bevers, and T. Barbui. 1997. Different anticoagulant and immunological properties of anti-prothrombin antibodies in patients with antiphospholipid antibodies. Thromb. Haemost. 77:486.
7. Field, S. L., P. J. Hogg, E. B. Daly, Y-P. Dai, B. Murray, D. Owens, and C. N. Chesterman. 1999. Lupus anticoagulants form immune complexes with prothrombin and phospholipid that can augment thrombin production in flow. Blood 94:3421.
8. Rao, L. V. M., A. D. Hoang, and S. I. Rapaport. 1996. Mechanism and effects of the binding of lupus anticoagulant IgG and prothrombin to surface phospholipid. Blood 88:4173.
9. Ferro, D., C. Quintarelli, G. Valesini, and F. Violi. 1994. Lupus anticoagulant and increased thrombin generation in patients with systemic lupus erythematosus. Blood 83:304.
10. Musial, J., J. Swadzba, M. Jankowski, M. Grzywacz, S. Bazan-Socha, and A. Szczeklik. 1997. Thrombin generation measured ex vivo following microvascular injury is increased in SLE patients with antiphospholipid-protein antibodies. Thromb. Haemost. 78:1173.
11. Brandt, J. T., D. A. Triplett, B. Alving, and I. Scharrer. 1995. Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thromb. Haemost. 74:1185.
12. Andrew, S. M., and J. A. Titus. 1997. Fragmentation of immunoglobulin G. In Current Protocols in Immunology. John Wiley & Sons, New York, pp. 2.8.1-2.8.10.
13. Huang, C. 1969. Studies on phosphatidylcholine vesicles: formation and physical characteristics. Biochemistry 8:344.
14. Mimms, L. T., G. Zampigi, Y. Nozaki, C. Tanford, and J. A. Reynolds. 1981. Phospholipid vesicle formation and transmembrane protein incorporation using octyl glucoside. Biochemistry 20:833.
15. Bartlett, G. R. 1959. Phosphorus assay in column chromatography. J. Biol. Chem. 234:466.
16. Bach, R., R. Gentry, and Y. Nemerson. 1986. Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine. Biochemistry 25:4007.
17. Hogg, P. J., and J. Stenflo. 1991. Interaction of vitamin K-dependent protein Z with thrombin: consequences for the amidolytic activity of thrombin and the interaction of thrombin with phospholipid vesicles. J. Biol. Chem. 266:10953.
18. Nelsestuen, G. L., and T. K. Lim. 1977. Equilibria involved in prothrombin- and blood-clotting factor X-membrane binding. Biochemistry 16:4164.
19. Lu, Y., and G. L. Nelsestuen. 1996. Dynamic features of prothrombin interaction with phospholipid vesicles of different size and composition: implications for protein-membrane contact. Biochemistry 35:8193.
20. Hogg, P. J., and C. M. Jackson. 1990. Heparin promotes the binding of thrombin to fibrin polymer: quantitative characterization of a thrombin-fibrin polymer-heparin ternary complex. J. Biol. Chem. 265:241.
21. Bode, W., D. Turk, and A. Karshikov. 1992. The refined 1.9-A x-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships. Protein Sci. 1:426.
22. Mason, D. W., and A. F. Williams. 1980. The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochem. J. 187:1.
23. Ong, G. L., and M. J. Mattes. 1993. Re-evaluation of the concept of functional affinity as applied to bivalent antibody binding to cell surface antigens. Mol. Immunol. 30:1455.
24. 2-glycoprotein I in the absence of phospholipid. J. Immunol. 154:954.
25. 2-glycoprotein I complexes to lipid membranes. Biochemistry 35:13833.
26. 2GPI binding to phospholipids. J. Clin. Invest. 99:2260.
27. 2-glycoprotein I complexes on phospholipid surfaces. Thromb. Haemost. 79:79.
28. Adamson, A. W. 1973. A Textbook of Physical Chemistry. Academic Press, New York, p. 195.