Preparation of penta-azole containing cyclopeptides: challenges in macrocyclization

Tetrahedron

Volumn 63, Issue 39, 2007, Pages 9862-9870

  Hernández, Delia ^a   Riego, Estela ^a   Francesch, Andrés ^b   Cuevas, Carmen ^b   Albericio, Fernando ^a,c   Álvarez, Mercedes ^a,c  

^a Barcelona Science Park   (Spain)

^b PHARMAMAR S A   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPEPTIDE; IB 01211; METHYL 2' [2 [2' (2 TERT BUTOXY 1 TERT BUTOXYCARBONYLAMINOETHYL)[2,4']BISOXAZOL 4 YL]THIAZOL 4 YL] 5 PHENYL[2,4']BISOXAZOLYL 4 CARBOXYLIC ACID; NATURAL PRODUCT; PENTETRAZOLE; TELOMESTATIN; UNCLASSIFIED DRUG; YM 216391;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOMIMETICS; BREAST CARCINOMA; CANCER CELL CULTURE; CHEMICAL REACTION; COLON CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; CYCLIZATION; CYTOTOXICITY; DRUG SYNTHESIS; EPIMER; HUMAN; HUMAN CELL; LUNG CARCINOMA; OXIDATION; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 34547764254     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.06.103     Document Type: Article

References (36)

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36. Assays of coelution in the HPLC of the natural product and the obtained macrocyclic peptide demonstrated that both compounds were different. A sample of IB-01211 was kindly supplied by PharmaMar S.L.