Mechercharmycins A and B, cytotoxic substances from marine-derived Thermoactinomyces sp. YM3-251

Journal of Antibiotics

Volumn 58, Issue 4, 2005, Pages 289-292

  Kanoh, Kaneo ^a   Matsuo, Yoshihide ^a   Adachi, Kyoko ^a   Imagawa, Hiroshi ^b   Nishizawa, Mugio ^b   Shizuri, Yoshikazu ^a  

^a MARINE BIOTECHNOLOGY INSTITUTE   (Japan)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

Cyclic peptide; Cytotoxic; Marine derived Thermoactinomyces

Indexed keywords

CYCLOPEPTIDE; CYTOTOXIC AGENT; MECHERCHARMYCIN A; MECHERCHARMYCIN B; OXAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; FUNGAL STRAIN; HUMAN; HUMAN CELL; IC 50; MARINE ENVIRONMENT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; THERMOACTINOMYCES; X RAY CRYSTALLOGRAPHY;

THERMOACTINOMYCES; THERMOACTINOMYCES SP.;

EID: 19644386054     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2005.36     Document Type: Article

References (8)

1. Blunt JW, Copp BR, Munro MHG, Northcote PT, Prinsep MR. Marine natural products. Nat Prod Rep 21: 1-49 (2004)
2. Compound 1 was reported as a cytotoxic substance in a patent during the preparation of this manuscript. Romero P, Malet L, Canedo LM, Cuevas C, Fernando RJ. New cytotoxic depsipeptides. WO 2005/000880 A2, January 6, 2005
3. The strain producing 1 and 2, YM3-251, has been identified as Thermoactinomyces sp. by taxonomic studies, including a 16S rDNA sequence analysis. The strain has been deposited in the NITE Patent Microorganisms Depositary (NPMD) in Japan as NITE P-2.
4. The B2 medium (1 liter) contained 5 g of peptone, l g of yeast extract, 0.1 g of iron (III) citrate n-hydrate, 750 ml of filtered natural sea water, and 250 ml of distilled water (pH 7.6, before sterilization).
5. Shin-ya K, Wierzba K, Matsuo K, Ohtani T, Yamada Y, Furihata K, Hayakawa Y, Seto H. Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus. J Am Chem Soc 123: 1262-1263 (2001)
6. α radiation (λ = 071073Å). The crystal structure was solved by the direct method with SIR-97. Refinement was performed by a full matrix least squares refinement on F2 with SHELXL-97. CCDC 262340 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/ data_request/cif.
7. Marfey P. Determination of D-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene. Carlsberg Res Commun 49: 591-596, 1984
8. -8M.