Synthesis and establishment of stereochemistry of the unusual polyoxazole-thiazole based cyclopeptide YM-216391 isolated from Streptomyces nobilis

Chemical Communications

Volumn , Issue 6, 2005, Pages 797-799

  Deeley, Jon ^a   Pattenden, Gerald ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPEPTIDE; NATURAL PRODUCT; OXAZOLE DERIVATIVE; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; YM 216391;

ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; STEREOCHEMISTRY; STREPTOMYCES; STREPTOMYCES NOBILIS; STRUCTURE ANALYSIS;

EID: 14644401735     PISSN: 13597345     EISSN: None     Source Type: Journal    
DOI: 10.1039/b416530f     Document Type: Article

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15. 6) 9.15 (1H, s), 9.05 (1H, s), 8.95 (1H, s), 8.71 (1H, s), 8.58 (1H, d, J = 8.4 Hz), 8.47 (2H, d, J = 7.1 Hz), 8.47-8.40 (1H, m), 7.98 (1H, d, J = 5.6 Hz), 7.62-7.49 (3H, m), 5.13 (1H, dd, J = 17.2 and 8.9 Hz), 4.68 (1H, dd, J = 8.4 and 5.5 Hz), 4.20-4.08 (2H, m), 2.18-2.07 (1H, m), 2.06-1.98 (1H, m), 1.68-1.53 (1H, m), 1.29-1.13 (1H, m) and 1.02-0.71 (12H, m) ppm.
16. +] requires 719.2012.