Insulin as a T cell antigen in type 1 diabetes supported by the evidence from the insulin knockout NOD mice

Diabetes Research and Clinical Practice

Volumn 77, Issue 3 SUPPL., 2007, Pages

  Moriyama, Hiroaki ^a   Nagata, Masao ^a   Arai, Takashi ^a   Okumachi, Yasuyo ^a   Yamada, Katsumi ^a   Kotani, Reiko ^a   Yasuda, Hisafumi ^a   Hara, Kenta ^a   Yokono, Koich ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoantigen; Autoimmune; ELISPOT; Insulin; Type 1 diabetes

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; GLUTAMATE DECARBOXYLASE 65; INSULIN; INSULIN ANTIBODY; PREPROINSULIN; T LYMPHOCYTE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CONGENIC STRAIN; CONTROLLED STUDY; ENZYME LINKED IMMUNOSPOT ASSAY; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; KNOCKOUT MOUSE; LABORATORY DIAGNOSIS; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; POLYMERASE CHAIN REACTION; SPLEEN CELL; STATISTICAL ANALYSIS; VARIABLE NUMBER OF TANDEM REPEAT;

ANIMALS; DIABETES MELLITUS, TYPE 1; HOMOZYGOTE; INSULIN; INSULIN ANTIBODIES; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; T-LYMPHOCYTES;

EID: 34547692897     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2007.01.050     Document Type: Article

References (26)

1. Hanahan D. Peripheral-antigen-expressing cells in thymic medulla: factors in self-tolerance and autoimmunity. Curr. Opin. Immunol. 10 (1998) 656-662
2. Yu L., Robles D.T., Abiru N., Kaur P., Rewers M., Kelemen K., et al. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. PNAS 97 (2000) 1701-1706
3. Bonifacio E., Atkinson M., Eisenbarth G., Serreze D., Kay T.W., Lee-Chan E., et al. International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice. Diabetes 50 (2001) 2451-2458
4. Daniel D., Gill R.G., Schloot N., and Wegmann D. Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur. J. Immunol. 25 (1995) 1056-1062
5. Alleva D.G., Crowe P.D., Jin L., Kwok W.W., Ling N., Gottschalk M., et al. A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J. Clin. Invest. 107 (2001) 173-180
6. Zhang Z.J., Davidson L., Eisenbarth G., and Weiner H.L. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. USA 88 (1991) 10252-10256
7. Muir A., Peck A., Clare-Salzler M., Song Y.H., Cornelius J., Luchetta R., et al. Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J. Clin. Invest. 95 (1995) 628-634
8. Daniel D., and Wegmann D.R. Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). PNAS 93 (1996) 956-960
9. Hutchings P.R., and Cooke A. Comparative study of the protective effect afforded by intravenous administration of bovine or ovine insulin to young NOD mice. Diabetes 44 (1995) 906-910
10. Soares M.B., Schon E., Henderson A., Karathanasis S.K., Cate R., Zeitlin S., et al. RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Mol. Cell Biol. 5 (1985) 2090-2103
11. Moriyama H., Abiru N., Paronen J., Sikora K., Liu E., Miao D., et al. Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc. Natl. Acad. Sci. USA 100 (2003) 10376-10381
12. Deltour L., Leduque P., Blume N., Madsen O., Dubois P., Jami J., et al. Differential expression of the two nonallelic proinsulin genes in the developing mouse embryo. PNAS 90 (1993) 527-531
13. Paronen J., Moriyama H., Abiru N., Sikora K., Melanitou E., Babu S., et al. Establishing insulin 1 and insulin 2 knockout congenic strains on NOD genetic background. Ann. NY Acad. Sci. 1005 (2003) 205-210
14. R. Kotani, M. Nagata, H. Moriyama, M. Nakayama, K. Yamada, S.A., et al. Detection of GAD65-reactive T-Cells in type 1 diabetes by immunoglobulin-free ELISPOT assays, Diabetes Care 25 (2002) 1390-1397.
15. Robles D.T., Eisenbarth G.S., Dailey N.J.M., Peterson L.B., and Wicker L.S. Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic mice. Diabetes 52 (2003) 882-886
16. Chentoufi A.A., and Polychronakos C. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes 51 (2002) 1383-1390
17. Nakayama M., Babaya N., Miao D., Sikora K., Elliott J.F., and Eisenbarth G.S. Thymic expression of mutated B16:A preproinsulin messenger RNA does not reverse acceleration of NOD diabetes associated with insulin 2 (thymic expressed insulin) knockout. J. Autoimmunol. 25 (2005) 193-198
18. Nakayama M., Abiru N., Moriyama H., Babaya N., Liu E., Miao D., et al. Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice. Nature 435 (2005) 220-223
19. Lee K.H., Wucherpfennig K.W., and Wiley D.C. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat. Immunol. 2 (2001) 501-507
20. Wong F.S., Karttunen J., Dumont C., Wen L., Visintin I., Pilip I.M., et al. Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat. Med. 5 (1999) 1026-1031
21. Zekzer D., Wong F.S., Wen L., Altieri M., Gurlo T., von Grafenstein H., et al. Inhibition of diabetes by an insulin-reactive CD4 T-cell clone in the nonobese diabetic mouse. Diabetes 46 (1997) 1124-1132
22. Du W., Wong F.S., Li M.O., Peng J., Qi H., Flavell R.A., et al. TGF-β signaling is required for the function of insulin-reactive T regulatory cells. J. Clin. Invest. 116 (2006) 1360-1370
23. Devendra D., Paronen J., Moriyama H., Miao D., Eisenbarth G.S., and Liu E. Differential immune response to B:9-23 insulin 1 and insulin 2 peptides in animal models of type 1 diabetes. J. Autoimmun. 23 (2004) 17-26
24. Moriyama H., Wen L., Abiru N., Liu E., Yu L., Miao D., et al. Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide. Proc. Natl. Acad. Sci. USA 99 (2002) 5539-5544
25. Bresson D., Togher L., Rodrigo E., Chen Y., Bluestone J.A., Herold K.C., et al. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J. Clin. Invest. 116 (2006) 1371-1381
26. Pugliese A. Peptide-based treatment for autoimmune diseases: learning how to handle a double-edged sword. J. Clin. Invest. 111 (2003) 1280-1282