Eukaryotic initiation factor 2α kinase is a nitric oxide-responsive mercury sensor enzyme: Potent inhibition of catalysis by the mercury cation and reversal by nitric oxide

FEBS Letters

Volumn 581, Issue 21, 2007, Pages 4109-4114

  Martinkova, Marketa ^a   Igarashi, Jotaro ^a   Shimizu, Toru ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

eIF2 kinase; Mercury; Metal cations; Nitric oxide; Protein synthesis; Translation

Indexed keywords

CADMIUM; COPPER ION; DITHIOTHREITOL; EDETIC ACID; FERROUS ION; HEME; INITIATION FACTOR 2ALPHA; LEAD; MERCAPTOETHANOL; MERCURY; NITRIC OXIDE; PROTEIN KINASE; ZINC ION;

ABSORPTION SPECTROSCOPY; ARTICLE; CATALYSIS; ENZYME ACTIVITY; IC 50; PLASMID; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; WILD TYPE;

ANIMALS; CATALYSIS; CATIONS, DIVALENT; DOSE-RESPONSE RELATIONSHIP, DRUG; EIF-2 KINASE; MERCURY; METALS, HEAVY; MICE; NITRIC OXIDE; PROTEIN BIOSYNTHESIS;

EUKARYOTA;

EID: 34547685914     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.07.055     Document Type: Article

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