Valproate induces apoptosis by inducing accumulation of neutral lipids which was prevented by disruption of the SIR2 gene in Saccharomyces cerevisiae

FEBS Letters

Volumn 581, Issue 21, 2007, Pages 3991-3995

  Sun, Qi ^a,b   Bi, Lifu ^b   Su, XiuLan ^b   Tsurugi, Kunio ^a   Mitsui, Kazuhiro ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

^b INNER MONGOLIA MEDICAL COLLEGE   (China)

Author keywords

Apoptosis; Budding yeast; Lipid accumulation; SIR2; Valproate

Indexed keywords

HISTONE DEACETYLASE; LIPID; NEUTRAL FAT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VALPROIC ACID;

APOPTOSIS; ARTICLE; CELL BUDDING; CELL DEATH; ENZYME ACTIVITY; FUNGAL GENE; FUNGAL STRAIN; GENE DELETION; GENE DISRUPTION; HDA1 GENE; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIR2 GENE;

APOPTOSIS; ENZYME INHIBITORS; GENE DELETION; HISTONE DEACETYLASES; LIPID METABOLISM; LIPIDS; REACTIVE OXYGEN SPECIES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; VALPROIC ACID;

SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 34547683373     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.07.030     Document Type: Article

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