Alternative splicing of an rnp-4f mRNA isoform retaining an evolutionarily-conserved 5′-UTR intronic element is developmentally regulated and shown via RNAi to be essential for normal central nervous system development in Drosophila melanogaster

Gene

Volumn 399, Issue 2, 2007, Pages 91-104

  Chen, Jing ^a   Concel, Vincent J ^b   Bhatla, Sunetra ^a   Rajeshwaran, Rajkumar ^a   Smith, Darcey L H ^a   Varadarajan, Malini ^a   Backscheider, Kimberly L ^a   Bockrath, Robyn A ^a   Petschek, Jane P ^b   Vaughn, Jack C ^a  

^a MIAMI UNIVERSITY   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

5 UTR intron retention; Alternative splicing; mRNA isoform; RNAi knockdown; Translation modulation

Indexed keywords

COMPLEMENTARY DNA; GENOMIC DNA; MESSENGER RNA; MESSENGER RNA PRECURSOR; PEPTIDE ANTIBODY; POLYCLONAL ANTIBODY; PROTEIN; RIBOSOME RNA; RNP 4F PROTEIN; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EMBRYO; EMBRYO DEVELOPMENT; GENE; GENE EXPRESSION; IN SITU HYBRIDIZATION; INTRON; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ELECTROPHORESIS; PROTEIN LOCALIZATION; RNA INTERFERENCE; RNA PROBE; RNA TRANSLATION; RNP 4F GENE; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

5' UNTRANSLATED REGIONS; ALTERNATIVE SPLICING; ANIMALS; CENTRAL NERVOUS SYSTEM; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INTRONS; RIBONUCLEOPROTEINS; RNA INTERFERENCE; RNA, MESSENGER;

DROSOPHILA MELANOGASTER;

EID: 34547681984     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2007.04.038     Document Type: Article

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