Structure-activity relationships for substrates and inhibitors of mammalian liver microsomal carboxylesterases

Pharmaceutical Research

Volumn 13, Issue 10, 1996, Pages 1495-1500

  Huang, Tien L ^a   Shiotsuki, Takahiro ^b   Uematsu, Tamon ^c   Borhan, Babak ^d   Li, Qing X ^e   Hammock, Bruce D ^d  

^a XAVIER UNIVERSITY OF LOUISIANA   (United States)

^b NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES   (Japan)

^c SUMITOMO CHEMICAL CO LTD   (Japan)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF HAWAII   (United States)

Author keywords

Carboxylesterase; Mammalian liver; Structure activity relationship; Thioester substrate; Trifluoromethylketone inhibitors

Indexed keywords

CARBOXYLESTERASE; ESTER; PESTICIDE; THIOESTER; XENOBIOTIC AGENT;

ANIMAL TISSUE; ARTICLE; DOG; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SPECIFICITY; HUMAN; HUMAN TISSUE; LIVER MICROSOME METABOLISM; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBOXYLIC ESTER HYDROLASES; ENZYME INHIBITORS; HUMANS; HYDROCARBONS, FLUORINATED; HYDROGEN-ION CONCENTRATION; KINETICS; MICE; MICROSOMES, LIVER; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SWINE;

EID: 0029999494     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016071311190     Document Type: Article

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