Determination of a selective Na+/H+ exchanger inhibitor, 4-cyano(benzo[b]thiophene-2-carbonyl)guanidine (KR-33028) in rat plasma by liquid chromatography-tandem mass spectrometry

Biomedical Chromatography

Volumn 21, Issue 8, 2007, Pages 810-815

  Kim, Young Hoon ^a   Ji, Hye Young ^b   Lee, Seonkyoung ^b   Yi, Kyu Yang ^b   Kim, You Sun ^c   Lee, Kyung Hee ^c   Lee, Hye Suk ^a  

^a Wonkwang University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

^c Yuyu Pharma Inc   (South Korea)

Author keywords

KR 33028; LC MS MS; Na+ H+ exchanger inhibitor; Rat plasma

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RATS;

KR-33028; LC-MS-MS; LC.MS/MS; LINEZOLID; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; NA+/H+ EXCHANGER INHIBITOR; RAT PLASMA; TANDEM MASS SPECTROMETRIC; [CARBONYL;

THIOPHENE;

4 CYANO(BENZO[B]THIOPHENE 2 CARBONYL)GUANIDINE; ACETIC ACID ETHYL ESTER; FORMIC ACID; KR 33028; LINEZOLID; METHANOL; PROTEIN INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

ANALYTICAL ERROR; ARTICLE; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; PH; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 34547671034     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.806     Document Type: Article

References (14)

1. + exchange inhibitors for cardioprotective therapy: progress, problems and prospects. Journal of the American College of Cardiology 2002; 39: 747-753.
2. Fischer H, Seelig A, Beier N, Raddatz P and Seelig J. New drugs for the Na+/H+ exchanger. Influence of Na+ concentration and determination of inhibition constants with a microphysiometer. Journal of Membrane Biology 1999, 168: 39-45.
3. + exchanger. European Journal of Pharmacology 2006; 535: 220-227.
4. Karmazyn M. Pharmacology and clinical assessment of cariporide for the treatment coronary artery diseases. Expert Opinion on Investigative Drugs 2000; 9: 1099-1108.
5. Kim H, Yoon YJ, Kim H, Cha EY, Lee HS, Kim JH, Yi KY, Lee S, Cheon HG, Yoo SE, Lee SS, Shin JG and Liu KH. In vitro metabolism of a new cardioprotective agent, KR-33028 in the human liver microsomes and cryopreserved human hepatocytes. Archives of Pharmacology Research 2005; 28: 1287-1292.
6. Kim H, Yoon YJ, Kim H, Kang S, Cheon HG, Yoo SE, Shin JG and Liu KH. Characterization of the cytochrome P450 enzymes involved in the metabolism of a new cardioprotective agent KR-33028. Toxicology Letters 2006; 166: 105-114.
7. + exchanger inhibitor, on functional and metabolic impairments produced by global ischemia and reperfusion in the perfused rat heart. European Journal of Pharmacology 2005a; 511: 175-182.
8. + exchanger isoform-1. Journal of Medicinal Chemistry 2005b; 48: 2882-2891.
9. Lee BH, Yi KY, Lee S, Lee S and Yoo SE. Effects of KR-32570, a new sodium hydrogen exchanger inhibitor, on myocardial infarction and arrhythmias induced by ischemia and reperfusion. European Journal of Pharmacology 2005c; 523: 101-108.
10. + exchanger isoform-1 (NHE-1) inhibitors. Bioorganic and Medicinal Chemistry Letters 2005d; 15: 2998-3001.
11. + exchanger. European Journal of Medicinal Chemistry 2003; 38: 547-554.
12. Matuszewski BK, Constanzer ML and Chavez-Eng CM. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Analytical Chemistry 2003; 75: 3019-3030.
13. Touret N, Tanneur V, Godart H, Seidler R, Taki N, Burger E, Dammgen J and Counillon L. Characterization of sabiporide, a new specific NHE-1 inhibitor exhibiting slow dissociation kinetics and cardioprotective effects. European Journal of Pharmacology 2003; 459: 151-158.
14. Tracey WR, Allen MC, Frazier DE, Fossa AA, Johnson CG, Marala RB, Knight DR and Guzman-Perez A. Zoniporide: a potent and selective inhibitor of the human sodium-hydrogen exchanger isoform 1 (NHE-1). Cardiovascular Drug Reviews 2003; 21: 17-32.