Diminished thrombus formation and alleviation of myocardial infarction and reperfusion injury through antibody- or small-molecule-mediated inhibition of selectin-dependent platelet functions

Haematologica

Volumn 92, Issue 4, 2007, Pages 502-512

  Oostingh, Gertie J ^a,b   Pozgajova, Miroslava ^a   Ludwig, Ralf J ^c   Krahn, Thomas ^d   Boehncke, W Henning ^c   Nieswandt, Bernhard ^a   Schön, Michael P ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d Pharmaceutical Research   (Germany)

Author keywords

Aggregation and thrombus formation; Platelets; Selectins

Indexed keywords

EFOMYCINE M; FERROUS CHLORIDE; IMMUNOGLOBULIN F(AB) FRAGMENT; PADGEM PROTEIN; PROTEIN ANTIBODY; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; 5 ACETYLNEURAMINYL (2 3) GALACTOSYL (1 4) (FUCOPYRANOSYL (1 3)) N ACETYLGLUCOSAMINE; 5-ACETYLNEURAMINYL-(2-3)-GALACTOSYL-(1-4)-(FUCOPYRANOSYL-(1-3))-N-ACETYLGLUCOSAMINE; ANTITHROMBOCYTIC AGENT; FERRIC CHLORIDE; FERRIC ION; FIBRINOLYTIC AGENT; MACROLIDE; MONOCLONAL ANTIBODY; OLIGOSACCHARIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY THROMBOSIS; ARTICLE; BIODEGRADATION; CELL ADHESION; CELL FUNCTION; CONTROLLED STUDY; FLOW KINETICS; HEART INFARCTION; HEART INFARCTION SIZE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; MICROSCOPY; MOUSE; NEUTROPHIL; NONHUMAN; NORMAL HUMAN; REPERFUSION INJURY; STATISTICAL SIGNIFICANCE; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOGENESIS; THROMBUS; VENULE; VIDEORECORDING; WILD TYPE; ANIMAL; BLOOD; BLOOD RHEOLOGY; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; DRUG SCREENING; ENDOTHELIUM CELL; IMMUNOLOGY; LEWIS RAT; MOLECULAR WEIGHT; MOUSE MUTANT; PATHOPHYSIOLOGY; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PHYSIOLOGY; RAT; THROMBOCYTE ADHESIVENESS; THROMBOSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; ARTERIAL OCCLUSIVE DISEASES; DRUG EVALUATION, PRECLINICAL; ENDOTHELIAL CELLS; FERRIC COMPOUNDS; FIBRINOLYTIC AGENTS; HEMORHEOLOGY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MACROLIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR WEIGHT; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; NEUTROPHILS; OLIGOSACCHARIDES; P-SELECTIN; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RATS; RATS, INBRED LEW; THROMBOSIS;

EID: 34547669348     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: 10.3324/haematol.10741     Document Type: Article

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