Effects of aging and cytokine blockade on inflammatory cachexia

Clinical and Experimental Rheumatology

Volumn 22, Issue 1, 2004, Pages 85-90

  Fathalla, Basil ^a,b   Hamada, Koichiro ^a   Vannier, Edouard ^a,b   Smith, Donald ^a   Edwards III, Carl ^c   Roubenoff, Ronenn ^a,b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS MEDICAL CENTER   (United States)

^c AMGEN INC   (United States)

Author keywords

Adjuvant arthritis; IL 1 and TNF; Inflammatory cachexia

Indexed keywords

CYTOKINE; FREUND ADJUVANT; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR RECEPTOR 1;

ADJUVANT ARTHRITIS; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CACHEXIA; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; INFLAMMATORY DISEASE; INJECTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RAT STRAIN; SCORING SYSTEM; STATISTICAL ANALYSIS; WEIGHT GAIN; WEIGHT REDUCTION;

AGING; ANIMALS; ARTHRITIS, EXPERIMENTAL; BODY WEIGHT; CACHEXIA; DISEASE MODELS, ANIMAL; FEMALE; FREUND'S ADJUVANT; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; JOINTS; MALE; RATS; RATS, INBRED LEW; RECEPTORS, TUMOR NECROSIS FACTOR; SIALOGLYCOPROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 1242308855     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. ROUBENOFF R, ROUBENOFF RA, KEHAYIAS JJ et al.: Rheumatoid cachexia: Cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation. J Clin Invest 1994; 93: 2379-86.
2. ROUBENOFF R, FREEMAN LM, SMITH DE, ABAD LW, DINARELLO CA, KEHAYIAS JJ: Adjuvant arthritis as a model of inflammatory cachexia. Arthritis Rheum 1997; 40: 534-9.
3. EISENBERG SP, EVANS RJ, AREND WP: Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist. Nature 1990; 343: 341-5.
4. FEIGE U, HU YL, GASSER J, CAMPAGNUOLO G, MUNYAKAZI L, BOLON B: Anti-interleukin-1 and anti-tumor necrosis factor-α synergistically inhibit adjuvant arthritis in Lewis rats. Cell Mol Life Sci 2000; 57: 1457-1470.
5. BENDELE AM, CHLIPALA ES, SCHERRER J et al.: Combination benefit of treatment with the cytokine inhibitors interleukin-1 receptor antagonist and PEGylated soluble tumor necrosis factor receptor Type I in animal models of rheumatoid arthritis. Arthritis Rheum 2000; 43: 2648-59.
6. McCOMB J, GOULD T, CHLIPALA E et al.: Anti-arthritic activity of soluble tumor necrosis factor receptor type I form in adjuvant arthritis: correlation of plasma levels with efficacy. J Rheumatol 1999; 26: 1347-51.
7. WILLIAMS RO, MARINOVA-MUTAFCHIEVA L, FELDMANN M, MAINI RN: Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha/anti-CD4 therapy. J Immunol 2000; 165: 7240-5.