메뉴 건너뛰기




Volumn 169, Issue 5, 2004, Pages 623-633

Role of Arousals in the Pathogenesis of Obstructive Sleep Apnea

Author keywords

Mechanisms; Obstructive sleep apnea; Ventilatory stability

Indexed keywords

ADULT; AIRWAY OBSTRUCTION; AIRWAY PRESSURE; APNEA; AROUSAL; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; RESPIRATORY AIRFLOW; RESPIRATORY FUNCTION; SLEEP APNEA SYNDROME;

EID: 1442300756     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200307-1023oc     Document Type: Article
Times cited : (352)

References (66)
  • 4
    • 0030854321 scopus 로고    scopus 로고
    • Respiratory arousal from sleep: Mechanisms and significance
    • Berry RB, Gleeson K. Respiratory arousal from sleep: mechanisms and significance. Sleep 1997;20:654-675.
    • (1997) Sleep , vol.20 , pp. 654-675
    • Berry, R.B.1    Gleeson, K.2
  • 8
    • 0036846297 scopus 로고    scopus 로고
    • Electroencephalographic spectral analysis: Detection of cortical activity changes in sleep apnoea patients
    • Dingli K, Assimakopoulos T, Fietze I, Witt C, Wraith PK, Douglas NJ. Electroencephalographic spectral analysis: detection of cortical activity changes in sleep apnoea patients. Eur Respir J 2002;20:1246-1253.
    • (2002) Eur Respir J , vol.20 , pp. 1246-1253
    • Dingli, K.1    Assimakopoulos, T.2    Fietze, I.3    Witt, C.4    Wraith, P.K.5    Douglas, N.J.6
  • 9
    • 0141617564 scopus 로고    scopus 로고
    • Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea
    • Younes M. Contributions of upper airway mechanics and control mechanisms to severity of obstructive apnea. Am J Respir Crit Care Med 2003;168:645-658.
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 645-658
    • Younes, M.1
  • 11
    • 0026604619 scopus 로고
    • Effect of ethanol on the arousal response to airway occlusion during sleep in normal subjects
    • Berry RB, Bonnet MH, Light RW. Effect of ethanol on the arousal response to airway occlusion during sleep in normal subjects. Am Rev Respir Dis 1992;145:445-452.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 445-452
    • Berry, R.B.1    Bonnet, M.H.2    Light, R.W.3
  • 12
    • 0031714081 scopus 로고    scopus 로고
    • Within-night variation in respiratory effort preceding apnea termination and EEG delta power in sleep apnea
    • Berry RB, Asyali MA, McNellis MI, Khoo MC. Within-night variation in respiratory effort preceding apnea termination and EEG delta power in sleep apnea. J Appl Physiol 1998;85:1434-1441.
    • (1998) J Appl Physiol , vol.85 , pp. 1434-1441
    • Berry, R.B.1    Asyali, M.A.2    McNellis, M.I.3    Khoo, M.C.4
  • 13
    • 0020036451 scopus 로고
    • Pathogenesis of apneas in hypersomnia-sleep apnea syndrome
    • Onal E, Lopata M, O'Connor T. Pathogenesis of apneas in hypersomnia-sleep apnea syndrome. Am Rev Respir Dis 1982;125:167-174.
    • (1982) Am Rev Respir Dis , vol.125 , pp. 167-174
    • Onal, E.1    Lopata, M.2    O'Connor, T.3
  • 14
    • 0027459837 scopus 로고
    • Role of chemical drive in recruiting upper airway and inspiratory intercostal muscles in patients with obstructive sleep apnea
    • Okabe S, Chonan T, Hida W, Satoh M, Kikuchi Y, Takishima T. Role of chemical drive in recruiting upper airway and inspiratory intercostal muscles in patients with obstructive sleep apnea. Am Rev Respir Dis 1993;147:190-195.
    • (1993) Am Rev Respir Dis , vol.147 , pp. 190-195
    • Okabe, S.1    Chonan, T.2    Hida, W.3    Satoh, M.4    Kikuchi, Y.5    Takishima, T.6
  • 15
    • 0028018230 scopus 로고
    • Upper airway muscle activity during REM and non-REM sleep of patients with obstructive apnea
    • Okabe S, Hida W, Kikuchi Y, Taguchi O, Takishima T, Shirato K. Upper airway muscle activity during REM and non-REM sleep of patients with obstructive apnea. Chest 1994;106:767-773.
    • (1994) Chest , vol.106 , pp. 767-773
    • Okabe, S.1    Hida, W.2    Kikuchi, Y.3    Taguchi, O.4    Takishima, T.5    Shirato, K.6
  • 16
    • 0030739921 scopus 로고    scopus 로고
    • Upper airway anesthesia reduces phasic genioglossus activity during sleep apnea
    • Berry RB, McNellis MI, Kouchi K, Light RW. Upper airway anesthesia reduces phasic genioglossus activity during sleep apnea. Am J Respir Crit Care Med 1997;156:127-132.
    • (1997) Am J Respir Crit Care Med , vol.156 , pp. 127-132
    • Berry, R.B.1    McNellis, M.I.2    Kouchi, K.3    Light, R.W.4
  • 17
    • 0023134275 scopus 로고
    • Inspiratory muscle activity as a trigger causing the airways to open in obstructive sleep apnea
    • Vincken W, Guilleminault C, Silvestri L, Cosio M, Grassino A. Inspiratory muscle activity as a trigger causing the airways to open in obstructive sleep apnea. Am Rev Respir Dis 1987;135:372-377.
    • (1987) Am Rev Respir Dis , vol.135 , pp. 372-377
    • Vincken, W.1    Guilleminault, C.2    Silvestri, L.3    Cosio, M.4    Grassino, A.5
  • 18
    • 0025282912 scopus 로고
    • The influence of increasing ventilatory effort on arousal from sleep
    • Gleeson K, Zwillich CW, White DP. The influence of increasing ventilatory effort on arousal from sleep. Am Rev Respir Dis 1990;142:295-300.
    • (1990) Am Rev Respir Dis , vol.142 , pp. 295-300
    • Gleeson, K.1    Zwillich, C.W.2    White, D.P.3
  • 20
    • 0026710329 scopus 로고
    • Effect of hyperoxia on the arousal response to airway occlusion during sleep in normal subjects
    • Berry RB, Light RW. Effect of hyperoxia on the arousal response to airway occlusion during sleep in normal subjects. Am Rev Respir Dis 1992;146:330-334.
    • (1992) Am Rev Respir Dis , vol.146 , pp. 330-334
    • Berry, R.B.1    Light, R.W.2
  • 21
    • 0027231004 scopus 로고
    • Effect of hypercapnia on the arousal response to airway occlusion during sleep in normal subjects
    • Berry RB, Mahutte CK, Light RW. Effect of hypercapnia on the arousal response to airway occlusion during sleep in normal subjects. J Appl Physiol 1993;74:2269-2275.
    • (1993) J Appl Physiol , vol.74 , pp. 2269-2275
    • Berry, R.B.1    Mahutte, C.K.2    Light, R.W.3
  • 23
    • 0027493413 scopus 로고
    • Influence of sleep on response to negative airway pressure of tensor palatini muscle and retropalatal airway
    • Wheatley JR, Tangel DJ, Mezzanotte WS, White DP. Influence of sleep on response to negative airway pressure of tensor palatini muscle and retropalatal airway. J Appl Physiol 1993;75:2117-2124.
    • (1993) J Appl Physiol , vol.75 , pp. 2117-2124
    • Wheatley, J.R.1    Tangel, D.J.2    Mezzanotte, W.S.3    White, D.P.4
  • 24
    • 0027194295 scopus 로고
    • Influence of sleep on genioglossus muscle activation by negative pressure in normal men
    • Wheatley JR, Mezzanotte WS, Tangel DJ, White DP. Influence of sleep on genioglossus muscle activation by negative pressure in normal men. Am Rev Respir Dis 1993;148:597-605.
    • (1993) Am Rev Respir Dis , vol.148 , pp. 597-605
    • Wheatley, J.R.1    Mezzanotte, W.S.2    Tangel, D.J.3    White, D.P.4
  • 25
    • 0028269943 scopus 로고
    • The effect of sleep on reflex genioglossus muscle activation by stimuli of negative airway pressure in humans
    • Horner RL, Innes JA, Morrell MJ, Shea SA, Guz A. The effect of sleep on reflex genioglossus muscle activation by stimuli of negative airway pressure in humans. J Physiol 1994;476:141-151.
    • (1994) J Physiol , vol.476 , pp. 141-151
    • Horner, R.L.1    Innes, J.A.2    Morrell, M.J.3    Shea, S.A.4    Guz, A.5
  • 26
    • 0029013172 scopus 로고
    • Central and reflex neural control of genioglossus in subjects who underwent laryngectomy
    • Innes JA, Morrell MJ, Kobayashi I, Hamilton RD, Guz A. Central and reflex neural control of genioglossus in subjects who underwent laryngectomy. J Appl Physiol 1995;78:2180-2186.
    • (1995) J Appl Physiol , vol.78 , pp. 2180-2186
    • Innes, J.A.1    Morrell, M.J.2    Kobayashi, I.3    Hamilton, R.D.4    Guz, A.5
  • 27
    • 0029976342 scopus 로고    scopus 로고
    • Effects of genioglossal response to negative airway pressure on upper airway collapsibility during sleep
    • Philip-Joet F, Marc I, Series F. Effects of genioglossal response to negative airway pressure on upper airway collapsibility during sleep. J Appl Physiol 1996;80:1466-1474.
    • (1996) J Appl Physiol , vol.80 , pp. 1466-1474
    • Philip-Joet, F.1    Marc, I.2    Series, F.3
  • 30
    • 0000345845 scopus 로고
    • The physiologic basis of central apnea and periodic breathing
    • Younes M. The physiologic basis of central apnea and periodic breathing. Curr Pulmonol 1989;10:265-326.
    • (1989) Curr Pulmonol , vol.10 , pp. 265-326
    • Younes, M.1
  • 31
    • 0025806024 scopus 로고
    • Sleep-induced periodic breathing and apnea: A theoretical study
    • Khoo MC, Gottschalk A, Pack AI. Sleep-induced periodic breathing and apnea: a theoretical study. J Appl Physiol 1991;70:2014-2024.
    • (1991) J Appl Physiol , vol.70 , pp. 2014-2024
    • Khoo, M.C.1    Gottschalk, A.2    Pack, A.I.3
  • 32
    • 0029863308 scopus 로고    scopus 로고
    • Ventilatory dynamics during transient arousal from NREM sleep: Implications for respiratory control stability
    • Khoo MC, Koh SS, Shin JJ, Westbrook PR, Berry RB. Ventilatory dynamics during transient arousal from NREM sleep: implications for respiratory control stability. J Appl Physiol 1996;80:1475-1484.
    • (1996) J Appl Physiol , vol.80 , pp. 1475-1484
    • Khoo, M.C.1    Koh, S.S.2    Shin, J.J.3    Westbrook, P.R.4    Berry, R.B.5
  • 34
    • 26344447666 scopus 로고    scopus 로고
    • Response to de novo upper airway collapse in patients with obstructive sleep apnea
    • Younes M. Response to de novo upper airway collapse in patients with obstructive sleep apnea [abstract]. Am J Respir Crit Care Med 2003; 167:A599.
    • (2003) Am J Respir Crit Care Med , vol.167
    • Younes, M.1
  • 36
    • 0003062284 scopus 로고
    • Scoring rules and examples: A preliminary report from the sleep disorders atlas task force of the American sleep disorders association
    • Arousals EEG. Scoring rules and examples: a preliminary report from the sleep disorders atlas task force of the American sleep disorders association. Sleep 1992;15:174-184.
    • (1992) Sleep , vol.15 , pp. 174-184
    • Arousals, E.E.G.1
  • 37
    • 0033178851 scopus 로고    scopus 로고
    • Sleep-related breathing disorders in adults: Recommendations for syndrome definition and measurement techniques in clinical research. The report of an American Academy of Sleep Medicine Task Force
    • Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The report of an American Academy of Sleep Medicine Task Force. Sleep 1999;22:667-689.
    • (1999) Sleep , vol.22 , pp. 667-689
  • 38
    • 0029870047 scopus 로고    scopus 로고
    • EEG frequency changes during sleep apneas
    • Svanborg E, Guilleminault C. EEG frequency changes during sleep apneas. Sleep 1996;19:248-254.
    • (1996) Sleep , vol.19 , pp. 248-254
    • Svanborg, E.1    Guilleminault, C.2
  • 39
    • 0034284322 scopus 로고    scopus 로고
    • Cardiac activation during arousal in humans: Further evidence for hierarchy in the arousal response
    • Sforza E, Jouny C, Ibanez V. Cardiac activation during arousal in humans: further evidence for hierarchy in the arousal response. Clin Neurophysiol 2000;111:1611-1619.
    • (2000) Clin Neurophysiol , vol.111 , pp. 1611-1619
    • Sforza, E.1    Jouny, C.2    Ibanez, V.3
  • 40
    • 0027456250 scopus 로고
    • Arterial blood pressure responses to graded transient arousal from sleep in normal humans
    • Davies RJ, Belt PJ, Roberts SJ, Ali NJ, Stradling JR. Arterial blood pressure responses to graded transient arousal from sleep in normal humans. J Appl Physiol 1993;74:1123-1130.
    • (1993) J Appl Physiol , vol.74 , pp. 1123-1130
    • Davies, R.J.1    Belt, P.J.2    Roberts, S.J.3    Ali, N.J.4    Stradling, J.R.5
  • 42
    • 0027982287 scopus 로고
    • Changes in pulse transit time and pulse rate as markers of arousal from sleep in normal subjects
    • Pitson D, Chhina N, Knijn S, van Herwaaden M, Stradling J. Changes in pulse transit time and pulse rate as markers of arousal from sleep in normal subjects. Clin Sci 1994;87:269-273.
    • (1994) Clin Sci , vol.87 , pp. 269-273
    • Pitson, D.1    Chhina, N.2    Knijn, S.3    Van Herwaaden, M.4    Stradling, J.5
  • 43
    • 0036838815 scopus 로고    scopus 로고
    • Noninvasive cardiovascular markers of acoustically induced arousal from non-rapid-eye-movement sleep
    • Catcheside PG, Chiong SC, Mercer J, Saunders NA, McEvoy RD. Noninvasive cardiovascular markers of acoustically induced arousal from non-rapid-eye- movement sleep. Sleep 2002;25:797-804.
    • (2002) Sleep , vol.25 , pp. 797-804
    • Catcheside, P.G.1    Chiong, S.C.2    Mercer, J.3    Saunders, N.A.4    McEvoy, R.D.5
  • 44
    • 1442342350 scopus 로고    scopus 로고
    • The cardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans
    • Oct 24 (Epub ahead of print)
    • O'Driscoll DM, Meadows GE, Corfield DR, Simonds AK, Morrell MJ. The cardiovascular response to arousal from sleep under controlled conditions of central and peripheral chemoreceptor stimulation in humans. J Appl Physiol 2003 Oct 24 (Epub ahead of print).
    • (2003) J Appl Physiol
    • O'Driscoll, D.M.1    Meadows, G.E.2    Corfield, D.R.3    Simonds, A.K.4    Morrell, M.J.5
  • 49
    • 0033083891 scopus 로고    scopus 로고
    • Arousal threshold to respiratory stimuli in OSA patients: Evidence for a sleep-dependent temporal rhythm
    • Sforza E, Krieger J, Petiau C. Arousal threshold to respiratory stimuli in OSA patients: evidence for a sleep-dependent temporal rhythm. Sleep 1999;22:69-75.
    • (1999) Sleep , vol.22 , pp. 69-75
    • Sforza, E.1    Krieger, J.2    Petiau, C.3
  • 50
    • 0029994094 scopus 로고    scopus 로고
    • Influence of sleep onset on upper-airway muscle activity in apnea patients versus normal controls
    • Mezzanotte WS, Tangel DJ, White DP. Influence of sleep onset on upper-airway muscle activity in apnea patients versus normal controls. Am J Respir Crit Care Med 1996;153:1880-1887.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1880-1887
    • Mezzanotte, W.S.1    Tangel, D.J.2    White, D.P.3
  • 51
    • 0035870835 scopus 로고    scopus 로고
    • Microdialysis perfusion of 5-HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats
    • Jelev A, Sood S, Liu H, Nolan P, Horner RL. Microdialysis perfusion of 5-HT into hypoglossal motor nucleus differentially modulates genioglossus activity across natural sleep-wake states in rats. J Physiol 2001;532:467-481.
    • (2001) J Physiol , vol.532 , pp. 467-481
    • Jelev, A.1    Sood, S.2    Liu, H.3    Nolan, P.4    Horner, R.L.5
  • 52
    • 0031847386 scopus 로고    scopus 로고
    • Ventilatory dynamics of transient arousal in patients with obstructive sleep apnea
    • Khoo MC, Shin JJ, Asyali MH, Kim TS, Berry RB. Ventilatory dynamics of transient arousal in patients with obstructive sleep apnea. Respir Physiol 1998;112:291-303.
    • (1998) Respir Physiol , vol.112 , pp. 291-303
    • Khoo, M.C.1    Shin, J.J.2    Asyali, M.H.3    Kim, T.S.4    Berry, R.B.5
  • 54
    • 0020629231 scopus 로고
    • Arousal and breathing responses to airway occlusion in healthy sleeping adults
    • Issa FG, Sullivan CE. Arousal and breathing responses to airway occlusion in healthy sleeping adults. J Appl Physiol 1983;55:1113-1119.
    • (1983) J Appl Physiol , vol.55 , pp. 1113-1119
    • Issa, F.G.1    Sullivan, C.E.2
  • 55
    • 0027398765 scopus 로고
    • Arousal responses to added inspiratory resistance during REM and non-REM sleep in normal subjects
    • Gugger M, Bogershausen S, Schaffler L. Arousal responses to added inspiratory resistance during REM and non-REM sleep in normal subjects. Thorax 1993;48:125-129.
    • (1993) Thorax , vol.48 , pp. 125-129
    • Gugger, M.1    Bogershausen, S.2    Schaffler, L.3
  • 56
    • 0023835162 scopus 로고
    • Genioglossus and breathing responses to airway occlusion: Effect of sleep and route of occlusion
    • Issa FG, Edwards P, Szeto E, Lauff D, Sullivan C. Genioglossus and breathing responses to airway occlusion: effect of sleep and route of occlusion. J Appl Physiol 1988;64:543-549.
    • (1988) J Appl Physiol , vol.64 , pp. 543-549
    • Issa, F.G.1    Edwards, P.2    Szeto, E.3    Lauff, D.4    Sullivan, C.5
  • 57
    • 0025950363 scopus 로고
    • Changes in upper airway muscle activation and ventilation during phasic REM sleep in normal men
    • Wiegand L, Zwillich CW, Wiegand D, White DP. Changes in upper airway muscle activation and ventilation during phasic REM sleep in normal men. J Appl Physiol 1991;71:488-497.
    • (1991) J Appl Physiol , vol.71 , pp. 488-497
    • Wiegand, L.1    Zwillich, C.W.2    Wiegand, D.3    White, D.P.4
  • 58
    • 0030036990 scopus 로고    scopus 로고
    • Rapid-eye-movement-specific sleep-disordered breathing: A possible cause of excessive daytime sleepiness
    • Kass JE, Akers SM, Bartter TC, Pratter MR. Rapid-eye-movement-specific sleep-disordered breathing: a possible cause of excessive daytime sleepiness. Am J Respir Crit Care Med 1996;154:167-169.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 167-169
    • Kass, J.E.1    Akers, S.M.2    Bartter, T.C.3    Pratter, M.R.4
  • 59
    • 0034027806 scopus 로고    scopus 로고
    • Gender differences in the polysomnographic features of obstructive sleep apnea
    • O'Connor C, Thornley KS, Hanly PJ. Gender differences in the polysomnographic features of obstructive sleep apnea. Am J Respir Crit Care Med 2000;161:1465-1472.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 1465-1472
    • O'Connor, C.1    Thornley, K.S.2    Hanly, P.J.3
  • 60
    • 0036569980 scopus 로고    scopus 로고
    • Epidemiology of obstructive sleep apnea: A population health perspective
    • Young T, Peppard PE, Gottlieb DJ. Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002;165:1217-1239.
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1217-1239
    • Young, T.1    Peppard, P.E.2    Gottlieb, D.J.3
  • 61
    • 0002932278 scopus 로고
    • Normal aging
    • Kryger MH, Roth T, Dement WC, editors. Chap 63, Philadelphia, PA: WB Saunders
    • Bliwise DL. Normal aging. In: Kryger MH, Roth T, Dement WC, editors. Principles and practice of sleep medicine, 2nd ed., Chap 63, Philadelphia, PA: WB Saunders; 1994. p. 642-656.
    • (1994) Principles and Practice of Sleep Medicine, 2nd Ed. , pp. 642-656
    • Bliwise, D.L.1
  • 63
    • 0026875048 scopus 로고
    • Effects of enhancing slow-wave sleep by gamma-hydroxybutyrate on obstructive sleep apnea
    • Series F, Series I, Cormier Y. Effects of enhancing slow-wave sleep by gamma-hydroxybutyrate on obstructive sleep apnea. Am Rev Respir Dis 1992;145:1378-1383.
    • (1992) Am Rev Respir Dis , vol.145 , pp. 1378-1383
    • Series, F.1    Series, I.2    Cormier, Y.3
  • 65
    • 0030047161 scopus 로고    scopus 로고
    • A double-blind, randomized trial of sabeluzole-a putative glutamate antagonist-in obstructive sleep apnea
    • Hedner J, Grunstein R, Eriksson B, Ejnell H. A double-blind, randomized trial of sabeluzole-a putative glutamate antagonist-in obstructive sleep apnea. Sleep 1996;19:287-289.
    • (1996) Sleep , vol.19 , pp. 287-289
    • Hedner, J.1    Grunstein, R.2    Eriksson, B.3    Ejnell, H.4
  • 66
    • 1442342351 scopus 로고    scopus 로고
    • Pharmacotherapeutic trials for sleep-disordered breathing
    • Pack AI, editor. New York: Dekker; Lung Biology in Health and Disease. Chap. 21
    • Veasey SC. Pharmacotherapeutic trials for sleep-disordered breathing. In: Pack AI, editor. Sleep apnea: pathogenesis, diagnosis, and treatment. New York: Dekker; 2002, Lung Biology in Health and Disease. Vol. 166, Chap. 21. p. 607-622.
    • (2002) Sleep Apnea: Pathogenesis, Diagnosis, and Treatment , vol.166 , pp. 607-622
    • Veasey, S.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.