Protective effects of Fe-Aox29, a novel antioxidant derived from a molecular combination of Idebenone and vitamin E, in immortalized fibroblasts and fibroblasts from patients with Friedreich Ataxia

Molecular and Cellular Biochemistry

Volumn 302, Issue 1-2, 2007, Pages 79-85

  Jauslin, Matthias L ^a   Vertuani, Silvia ^b   Durini, Elisa ^b   Buzzoni, Lisa ^b   Ciliberti, Nunzia ^b   Verdecchia, Sara ^c   Palozza, Paola ^c   Meier, Thomas ^a   Manfredini, Stefano ^b  

^a Santhera Pharmaceuticals   (Switzerland)

^b UNIVERSITY OF FERRARA   (Italy)

^c CATHOLIC UNIVERSITY   (Italy)

Author keywords

Fe Aox29; Fibroblasts; Friedreich Ataxia; Idebenone; Oxidative stress; VitaminE

Indexed keywords

6 HYDROXY 2,5,7,8 TETRAMETHYL CHROMAN 2 CARBOXYLIC ACID 10 (4,5 DIMETHOXY 2 METHYL 3,6 DIOXOCYCLOHEXA 1,4 DIENYL)DECYL ESTER; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; IDEBENONE; THIOCTIC ACID; TROLOX C; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; CELL VIABILITY; COMBINATION CHEMOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SYNTHESIS; FIBROBLAST CULTURE; FRIEDREICH ATAXIA; HUMAN; HUMAN CELL; MONOTHERAPY; NEUROPROTECTION; OXIDATIVE STRESS;

ANIMALS; ANTIOXIDANTS; BENZOQUINONES; CELL LINE, TRANSFORMED; CELL SURVIVAL; CHROMANS; FIBROBLASTS; FRIEDREICH ATAXIA; HUMANS; HYDROGEN PEROXIDE; PROTECTIVE AGENTS; RATS; REACTIVE OXYGEN SPECIES; VITAMIN E;

EID: 34547627868     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9429-2     Document Type: Article

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