Slow inhibition of N-type calcium channels with GTPγS reflects the basal G protein-GDP turnover rate

Pflugers Archiv European Journal of Physiology

Volumn 446, Issue 2, 2003, Pages 183-188

  Chan, Allen W ^a,b   Stanley, Elise F ^a,b  

^a UNIVERSITY HEALTH NETWORK   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Ca channel; Ca channel inhibition; Ca channel modulation; G protein; GDP GTP exchange; GTP gamma S; Membrane delimited Dorsal root ganglion neuron

Indexed keywords

CALCIUM CHANNEL N TYPE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; NORADRENALIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING KINETICS; CALCIUM CURRENT; CALCIUM TRANSPORT; CELL ACTIVATION; CHICKEN; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; INHIBITION KINETICS; NERVE CELL; NONHUMAN; PERFUSION; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN INDUCTION; REDUCTION; SPINAL GANGLION;

EID: 0038519664     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-003-1030-2     Document Type: Article

References (30)

1. Bean BP (1989) Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature 340:153-156
2. + channel activation as revealed by hydrolysis-resistant GTP analogues. J Gen Physiol 91:469-493
3. Canfield DR, Dunlap K (1984) Pharmacological characterization of amine receptors on embryonic chick sensory neurones. Br J Pharmacol 82:557-565
4. Cismowski MJ, Takesono A, Bernard ML, Duzic E, Lanier SM (2001) Receptor-independent activators of heterotrimeric G-proteins. Life Sci 68:2301-2308
5. + channels (GIRKs). J Biol Chem 276:11409-11413
6. Cox DH, Dunlap K (1992) Pharmacological discrimination of N-type from L-type calcium current and its selective modulation by transmitters. J Neurosci 12:906-914
7. De Waard M, Liu H, Walker D, Scott VES, Gurnett CA, Campbell KP (1997) Direct binding of G-protein βγ complex to voltage-dependent calcium channels. Nature 385:446-450
8. Diversé-Pierluissi M, Dunlap K (1993) Distinct, convergent second messenger pathways modulate neuronal calcium currents. Neuron 10:753-760
9. Diversé-Pierluissi M, Dunlap K (1995) Interaction of convergent pathways that inhibit N-type calcium currents in sensory neurons. Neuroscience 65:477-483
10. Diverse-Pierluissi M, Goldsmith PK, Dunlap K (1995) Transmitter-mediated inhibition of N-type calcium channels in sensory neurons involves multiple GTP-binding proteins and subunits. Neuron 14:191-200
11. Diversé-Pierluissi M, Goldsmith PK, Dunlap K (1995) Transmitter-mediated inhibition of N-type calcium channels in sensory neurons involves multiple GTP-binding proteins and subunits. Neuron 14:191-200
12. 2+ channel inhibition. Neuron 16:579-585
13. Dolphin AC (1998) Mechanisms of modulation of voltage-dependent calcium channels by G proteins. J Physiol (Lond) 506:3-11
14. Dolphin AC, Wooten JF, Scott RH, Trentham DR (1988) Photoactivation of intracellular guanosine triphosphate analogues reduces the amplitude and slows the kinetics of voltage-activated calcium channel currents in sensory neurons. Pflugers Arch 411:628-636
15. Elmslie KS, Zhou W, Jones SW (1990) LHRH and GTP-gamma-S modify calcium current activation in bullfrog sympathetic neurons. Neuron 5:75-80
16. Grassi F, Lux H-D (1989) Voltage-dependent GABA-induced currents in chick sensory neurons. Neurosci Lett 105:113-119
17. 2+ channels by G-protein beta gamma subunits. Nature 380:258-262
18. 2+ on the GTPase activity and the fluorescent properties of Go. J Biol Chem 262:757-761
19. Hille B (1994) Modulation of ion channels by G-protein coupled receptors. Trends Neurosci 17:531-535
20. Hille B, Beech DJ, Bernheim L, Mathie A, Shapiro MS, Wollmuth LP (1995) Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons. Life Sci 56:989-992
21. Holz GG, Rane SG, Dunlap K (1986) GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels. Nature 319:670-672
22. Ikeda SR (1996) Voltage-dependent modulation of N-type calcium channels by G-protein β,γ-subunits. Nature 380:255-258
23. Ikeda SR, Dunlap K (1999) Voltage-dependent modulation of N-type calcium channels: role of G protein subunits. Adv Second Messenger Phosphoprotein Res 33:131-151
24. + channel. J Gen Physiol 99:961-983
25. + channel in heart. Nature 325:321-326
26. + channel. Proc Natl Acad Sci USA 85:5814-5818
27. Scott RH, Dolphin AC (1987) Activation of a G protein promotes agonist responses to calcium channel ligands. Nature 330:760-762
28. Zamponi GW, Snutch TP (1998) Decay of prepulse facilitation of N type calcium channels during G protein inhibition is consistent with binding of a single G-beta gamma subunit. Proc Natl Acad Sci USA 95:4035-4039
29. Zamponi GW, Bourinet E, Nelson D, Nargeot J, Snutch TP (1997) Crosstalk between G proteins and protein kinase C mediated by the calcium channel α1 subunit. Nature 385:442-446
30. 2+ channel modulation by neurotransmitters in rat sympathetic neurons. J Neurophysiol 77:2040-2048