A novel series of potent cytotoxic agents targeting G2/M phase of the cell cycle and demonstrating cell killing by apoptosis in human breast cancer cells

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 17, 2007, Pages 4955-4960

  Mandal, Soma ^a   Bérubé, Gervais ^b   Asselin, Éric ^b   Mohammad, Iqbal ^d   Richardson, Vernon J ^a   Gupta, Atul ^b   Pramanik, Saroj K ^c   Williams, Arthur L ^c   Mandal, Sanat K ^a,d  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^b UNIVERSITÉ DU QUÉBEC À TROIS RIVIÈRES   (Canada)

^c MORGAN STATE UNIVERSITY   (United States)

^d GIS Applications Specialist   (Canada)

Author keywords

Apoptosis; Cell cycle; Cytotoxic agent; Electron micrographs; Immunohistochemistry; MDA MB 468; Molecular modeling; p53273.His; Subcellular localization; Thiopyridine triazine; Triazine; TUNEL assay

Indexed keywords

CYTOTOXIC AGENT; SM 40; THIAZINE DERIVATIVE; THIOPYRIDINE TRIAZINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER MORTALITY; CELL CYCLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; G2 PHASE; HUMANS; HYDROGEN BONDING; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PYRIDINES; TRIAZINES;

EID: 34547518784     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.06.033     Document Type: Article

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