Stearoyl-CoA Desaturase Deficiency, Hypercholesterolemia, Cholestasis, and Diabetes

Nutrition Reviews

Volumn 65, Issue SUPPL.1, 2007, Pages

  Attie, Alan D ^a   Flowers, Matthew T ^a   Flowers, Jessica B ^a   Groen, Albert K ^b   Kuipers, Folkert ^c   Ntambi, James M ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Diabetes; Hypercholesterolemia; Leptin deficiency stearoyl CoA desaturase (Scd1) deficiency

Indexed keywords

ACYL COENZYME A DESATURASE; EDIBLE OIL; SCD1 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL; C57BL MOUSE; CARBOHYDRATE DIET; CHOLESTASIS; DISEASE MODEL; HUMAN; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; LIVER; LOW FAT DIET; METABOLISM; MOUSE; MOUSE MUTANT; NON INSULIN DEPENDENT DIABETES MELLITUS; REVIEW;

ANIMALS; CHOLESTASIS; DIABETES MELLITUS, TYPE 2; DIET, FAT-RESTRICTED; DIETARY CARBOHYDRATES; DIETARY FATS, UNSATURATED; DISEASE MODELS, ANIMAL; HUMANS; HYPERCHOLESTEROLEMIA; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; STEAROYL-COA DESATURASE;

EID: 34547468487     PISSN: 00296643     EISSN: 17534887     Source Type: Journal    
DOI: 10.1111/j.1753-4887.2007.tb00326.x     Document Type: Article

References (21)

1. Ntambi J., Miyazaki M. Recent insights into stearoyl-CoA desaturase-1. Curr Opin Lipidol 2003;14:S255-S261.
2. Miyazaki M., Kim Y., Ntambi J. A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyc-eride synthesis. J Lipid Res 2001;42:S1018-S1024.
3. Miyazaki M., Dobrzyn A., Man W. Stearoyl-CoA desaturase 1 gene expression is necessary for fructose-mediated induction of lipogenic gene expression by sterol regulatory element-binding protein-1c-dependent and -independent mechanisms. J Biol Chem 2004;279:S25164-S25171.
4. Attie A., Krauss R., Gray-Keller M. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceride-mia. J Lipid Res 2002;43:S1899-S1907.
5. Ntambi J., Miyazaki M., Stoehr J. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 2002;99:S11482-S11486.
6. Cohen P., Miyazaki M., Socci N. Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science 2002;297:S240-S243.
7. Rahman S., Dobrzyn A., Dobrzyn P. Stearoyl-CoA desaturase 1 deficiency elevates insulin-signaling components and down-regulates protein-tyrosine phosphatase 1B in muscle. Proc Natl Acad Sci USA 2003;100:S11110-S11115.
8. Nadler S., Attie A. Please pass the chips: genomic insights into obesity and diabetes. J Nutr 2001;131:S2078-S2081.
9. Coleman D. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Dia-betologia 1978;14:S141-S148.
10. Stoehr J., Nadler S., Schueler K. Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci. Diabetes 2000;49:S1946-S1954.
11. Lan H., Rabaglia M., Stoehr J. Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility. Diabetes 2003;52:S688-S700.
12. Colombo C., Haluzik M., Cutson J. Opposite effects of background genotype on muscle and liver insulin sensitivity of lipoatrophic mice. Role of triglyceride clearance. J Biol Chem 2003;278:S3992-S3999.
13. Millar J., Cromley D., McCoy M. Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339. J Lipid Res. 2005;46:S2023-S2028.
14. Havel R. The abnormal lipoprotein of cholestasis. N Engl J Med 1971;285:S578-S579.
15. Sakai N., Vaisman B., Koch C. Targeted disruption of the mouse lecithin: cholesterol acyltransferase (LCAT) gene. Generation of a new animal model for human LCAT deficiency. J Biol Chem 1997;272:S7506-S7510.
16. Shimabukuro M., Zhou Y., Levi M. Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 1998;95:S2498-S2502.
17. Lupi R., Dotta L., Marselli L. Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 2002;51:S1437-S1442.
18. Maedler K., Oberholser J., Bucher P. Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function. Diabetes 2003;52:S726-S733.
19. Maestre I., Jordan J., Calvo S. Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1. Endocrinology 2003;144:S335-S345.
20. Piro S., Anello M., Di Pietro C. Chronic exposure to free fatty acids or high glucose induces apoptosis in rat pancreatic islets: possible role of oxidative stress. Metabolism 2002;51:S1340-S1347.
21. El-Assaad W., Buteau J., Peyot M. Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death. Endocrinology 2003;144:S4154-S4163.