3-(Aminomethyl)-2-(carboxymethyl)isoxazolidinyl nucleosides: building blocks for peptide nucleic acid analogues

Tetrahedron Asymmetry

Volumn 18, Issue 13, 2007, Pages 1517-1520

  Merino, Pedro ^a   Tejero, Tomás ^a   Matés, Juan ^a   Chiacchio, Ugo ^b   Corsaro, Antonino ^b   Romeo, Giovanni ^c  

^a Instituto de Nanociencia y Materiales de Aragón   (Spain)

^b UNIVERSITY OF CATANIA   (Italy)

^c UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 (AMINOMETHYL) 2 (CARBOXYMETHYL)ISOXAZOLIDINYLNUCLEOSIDE DERIVATIVE; 3 (AMINOMETHYL) 2 (CARBOXYMETHYL)ISOXAZOLIDINYLTHYMINE; N GLYCOSYLNITRONE DERIVATIVE; NITRONE DERIVATIVE; NUCLEIC ACID; NUCLEOSIDE DERIVATIVE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; VINYL ACETATE;

ARTICLE; CHEMICAL REACTION KINETICS; CYCLOADDITION; ENANTIOSELECTIVITY; PRIORITY JOURNAL; REACTION ANALYSIS; SYNTHESIS;

EID: 34547462160     PISSN: 09574166     EISSN: 1362511X     Source Type: Journal    
DOI: 10.1016/j.tetasy.2007.06.029     Document Type: Article

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49. 3, 25 °C): δ 1.52 (br s, 9H), 1.97 (s, 3H), 2.20 (br s, 1H), 2.97-3.14 (m, 2H), 3.22-3.32 (m, 1H), 3.47 (br s, 1H), 3.54 (br d, 1H, J = 16.0 Hz), 3.74 (br d, 1H, J = 15.2 Hz), 4.21 (t, 1H, J = 5.9 Hz), 4.46 (br d, 2H, J = 5.9 Hz), 5.34 (br s, 1H), 6.00 (br s, 1H), 7.32-7.70 (m, 8H), 8.12 (br s, 1H), 8.73 (br s, 1H).