Hybridization of pyrrolidinyl peptide nucleic acids and DNA: Selectivity, base-pairing specificity, and direction of binding

Organic Letters

Volumn 8, Issue 9, 2006, Pages 1897-1900

  Vilaivan, Tirayut ^a   Srisuwannaket, Choladda ^a  

^a CHULALONGKORN UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PEPTIDE NUCLEIC ACID; PYRROLIDINE DERIVATIVE;

ARTICLE; BASE PAIRING; CHEMICAL STRUCTURE; CHEMISTRY; NUCLEIC ACID HYBRIDIZATION; NUCLEOTIDE SEQUENCE; SYNTHESIS;

BASE PAIRING; BASE SEQUENCE; DNA; MOLECULAR STRUCTURE; NUCLEIC ACID HYBRIDIZATION; PEPTIDE NUCLEIC ACIDS; PYRROLIDINES;

EID: 33646462305     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol060448q     Document Type: Article

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27. The term antiparallel used here means the pairing between PNA and DNA in such a way that the N-terminus of PNA faces the 3′-terminus of DNA and the C-terminus of the PNA faces the 5′-terminus of the DNA. The opposite orientation of binding is therefore parallel.
28. An exclusive antiparallel hybrid formation was observed in aegPNA 1 with its backbone partially modified by a few D-lysine "chiralbox" residues (ref 5b).
29. 9 = 76.9 °C.