Association analysis of vitamin D-binding protein gene polymorphisms with variations of obesity-related traits in Caucasian nuclear families

International Journal of Obesity

Volumn 31, Issue 8, 2007, Pages 1319-1324

  Jiang, H ^a,b   Xiong, D H ^b   Guo, Y F ^a,c   Shen, H ^b   Xiao, P ^b   Yang, F ^a,b   Chen, Y ^a,b   Zhang, F ^b,c   Recker, R R ^b   Deng, H W ^a,c,d  

^a HUNAN NORMAL UNIVERSITY   (China)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c XI'AN JIAOTONG UNIVERSITY   (China)

^d UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Association; DBP; PFM

Indexed keywords

FAT; VITAMIN D BINDING PROTEIN;

ADULT; ARTICLE; BODY FAT; BODY MASS; CAUCASIAN; COMPUTER PROGRAM; CONTROLLED STUDY; FAMILY STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NUCLEAR FAMILY; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; AGED, 80 AND OVER; BODY COMPOSITION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NUCLEAR FAMILY; OBESITY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX CHARACTERISTICS; UNITED STATES; VITAMIN D-BINDING PROTEIN;

EID: 34547431046     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/sj.ijo.0803583     Document Type: Article

References (34)

1. Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643.
2. Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX et al. Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss. Arterioscler Thromb Vasc Biol 2006; 26: 968-976.
3. Flegal KM, Carroll MD, Kuczmarski RJ, Johnson CL. Overweight and obesity in the United States: prevalence and trends, 1960-1994. Int J Obes Relat Metab Disord 1998; 22: 39-47.
4. Gallus S, Colombo P, Scarpino V, Zuccaro P, Negri E, Apolone G et al. Overweight and obesity in Italian adults 2004, and an overview of trends since 1983. Eur J Clin Nutr 2006; 60: 1174-1179.
5. Liu YJ, Liu PY, Long J, Lu Y, Elze L, Recker RR et al. Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families. Physiol Genomics 2005; 22: 197-203.
6. Sorensen TI, Holst C, Stunkard AJ. Adoption study of environmental modifications of the genetic influences on obesity. Int J Obes Relat Metab Disord 1998; 22: 73-81.
7. Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA 1986; 256: 51-54.
8. Perusse L, Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G et al. The human obesity gene map: the 2004 update. Obes Res 2005; 13: 381-490.
9. Witke WF, Gibbs PE, Zielinski R, Yang F, Bowman BH, Dugaiczyk A. Complete structure of the human Gc gene: differences and similarities between members of the albumin gene family. Genomics 1993; 16: 751-754.
10. White P, Cooke N. The multifunctional properties and characteristics of vitamin D-binding protein. Trends Endocrinol Metab 2000; 11: 320-327.
11. Gomme PT, Bertolini J. Therapeutic potential of vitamin D-binding protein. Trends Biotechnol 2004; 22: 340-345.
12. Arunabh S, Pollack S, Yeh J, Aloia JF. Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab 2003; 88: 157-161.
13. Reis AF, Hauache OM, Velho G. Vitamin D endocrine system and the genetic susceptibility to diabetes, obesity and vascular disease. A review of evidence. Diabetes Metab 2005; 31: 318-325.
14. Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 1985; 76: 370-373.
15. Buffington C, Walker B, Cowan Jr GS, Scruggs D. Vitamin D deficiency in the morbidly obese. Obes Surg 1993; 3: 421-424.
16. Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J et al. The relationship between obesity and serum 1, 25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004; 89: 1196-1199.
17. Arnaud J, Constans J. Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP). Hum Genet 1993; 92: 183-188.
18. Taes YE, Goemaere S, Huang G, Van Pottelbergh I, De Bacquer D, Verhasselt B et al. Vitamin D binding protein, bone status and body composition in community-dwelling elderly men. Bone 2006; 38: 701-707.
19. Pratley RE, Thompson DB, Prochazka M, Baier L, Mott D, Ravussin E et al. An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians. J Clin Invest 1998; 101: 1757-1764.
20. Iyengar S, Hamman RF, Marshall JA, Majumder PP, Ferrell RE. On the role of vitamin D binding globulin in glucose homeostasis: results from the San Luis Valley Diabetes Study. Genet Epidemiol 1989; 6: 691-698.
21. Hirai M, Suzuki S, Hinokio Y, Hirai A, Chiba M, Akai H et al. Variations in vitamin D-binding protein (group-specific component protein) are associated with fasting plasma insulin levels in Japanese with normal glucose tolerance. J Clin Endocrinol Metab 2000; 85: 1951-1953.
22. Xiong DH, Liu YZ, Liu PY, Zhao LJ, Deng HW. Association analysis of estrogen receptor alpha gene polymorphisms with cross-sectional geometry of the femoral neck in Caucasian nuclear families. Osteoporos Int 2005; 16: 2113-2122.
23. O'Connell JR, Weeks DE. PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 1998; 63: 259-266.
24. Abecasis GR, Cherny SS, Cookson WO, Cardon LR. Merlin - rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30: 97-101.
25. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265.
26. Li J, Jiang T. Computing the minimum recombinant haplotype configuration from incomplete genotype data on a pedigree by integer linear programming. J Comput Biol 2005; 12: 719-739.
27. Horvath S, Xu X, Laird NM. The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 2001; 9: 301-306.
28. Lange C, Silverman EK, Xu X, Weiss ST, Laird NM. A multivariate family-based association test using generalized estimating equations: FBAT-GEE. Biostatistics 2003; 4: 195-206.
29. Horvath S, Xu X, Lake SL, Silverman EK, Weiss ST, Laird NM. Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genet Epidemiol 2004; 26: 61-69.
30. Thomson G. Mapping disease genes: family-based association studies. Am J Hum Genet 1995; 57: 487-498.
31. Allison DB, Saunders SE. Obesity in North America. An overview. Med Clin North Am 2000; 84: 305-332, v.
32. Fang Y, van Meurs JB, d'Alesio A, Jhamai M, Zhao H, Rivadeneira F et al. Promoter and 3′-untranslated-region haplotypes in the vitamin D receptor gene predispose to osteoporotic fracture: the Rotterdam study. Am J Hum Genet 2005; 77: 807-823.
33. Okura T, Koda M, Ando F, Niino N, Ohta S, Shimokata H. Association of polymorphisms in the estrogen receptor alpha gene with body fat distribution. Int J Obes Relat Metab Disord 2003; 27: 1020-1027.
34. Mittendorfer B. Insulin resistance: sex matters. Curr Opin Clin Nutr Metab Care 2005; 8: 367-372.