Acetylcholine receptor organization at the dystrophic extraocular muscle neuromuscular junction

Anatomical Record

Volumn 290, Issue 7, 2007, Pages 846-854

  Marques, Maria Julia ^a   Pertille, Adriana ^a   Carvalho, Candida Luiza T ^a   Santo Neto, Humberto ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Acetylcholine receptors; Extraocular muscles; Mdx mice; Muscle regeneration; Neuromuscular junction

Indexed keywords

ALPHA BUNGAROTOXIN RHODAMINE; BUNGAROTOXIN; CHOLINERGIC RECEPTOR; DYSTROPHIN; FLUORESCENT DYE; NEUROFILAMENT PROTEIN; NEUROFILAMENT PROTEIN H; RHODAMINE; RHODAMINE-ALPHA-BUNGAROTOXIN; UNCLASSIFIED DRUG;

ANIMAL; ANIMAL MUSCULAR DYSTROPHY; ARTICLE; C57BL MOUSE; CONFOCAL MICROSCOPY; DISEASE MODEL; DUCHENNE MUSCULAR DYSTROPHY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; INNERVATION; MALE; METABOLISM; MOUSE; NEUROMUSCULAR SYNAPSE; PATHOLOGY; REGENERATION; SKELETAL MUSCLE; SYNAPTOSOME; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ANIMALS; BUNGAROTOXINS; DISEASE MODELS, ANIMAL; DYSTROPHIN; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED MDX; MICROSCOPY, CONFOCAL; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, ANIMAL; MUSCULAR DYSTROPHY, DUCHENNE; NEUROFILAMENT PROTEINS; NEUROMUSCULAR JUNCTION; PRESYNAPTIC TERMINALS; RECEPTORS, CHOLINERGIC; REGENERATION; RHODAMINES;

EID: 34547402504     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.20525     Document Type: Article

References (34)

1. Anderson JT, Rogers RP, Jarrett HW. 1996. Ca2-Calmodulin binds to the carboxyl-terminal domain of dystrophin. J Biol Chem 271:6605-6610.
2. Andrade FH, Porter JD, Kaminski HJ. 2000. Eye muscle sparing by the muscular dystrophies: lessons to be learned? Micros Res Tech 8:192-203.
3. Balice-Gordon RJ, Lichtman JW. 1993. In vivo observation of preand postsynaptic changes during the transition from multiple to single innervation at developing neuromuscular junctions. J Neurosci 13:834-855.
4. Banks GB, Fuhrer C, Adams ME, Froehner SC. 2003. The postsynaptic submembrane machinery at the neuromuscular junction: requirement for rapsyn and utrophin/dystrophin-associated complex. J Neurocytol 32:709-726.
5. Banks GB, Chamberlain JS, Froehner SC. 2005.Dystrophin is required to stabilize neuromuscular synapses independent of muscle regeneration. In: Society's Annual Meeting, 35, Washington, DC. Abstract view. Online. Program No. 493.17.
6. Bertorini TE, Bhattacharya SK, Palmieri GMMA, Chesney CM, Pifer D, Baker B. 1982. Muscle calcium and magnesium content in Duchenne muscular dystrophy. Neurology 32:1088-1092.
7. Budak MT, Bogdanovich S, Wiesen MHJ, Lozynska O, Khurana TS, Rubinstein NA. 2004. Layer-specific differences of gene expression in extraocular muscles identified by laser-capture microscopy. Physiol Genom 20:55-65.
8. Bulfield G, Siller WG, Wight PAL, Moore KJ. 1984. X chromosome-linked muscular dystrophy (mdx) in the mouse. Proc Natl Acad Sci U S A 81:1189-1192.
9. Desaki J. 1990. The morphological variability of neuromuscular junctions in the rat extraocular muscles: a scanning electron microscopical study. Arch Histol Cytol 53:275-281.
10. Engel AG, Yamamoto M, Fischbeck KH. 1994. Muscular dystrophies. In: Engel AG, Franzini-Armstrong C, editors. Myology. New York: McGraw-Hill. p 1133-1187.
11. Hoffman EP, Brown RH Jr, Kunkel LM. 1987. Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 51:919-928.
12. Khanna S, Richmonds CR, Kaminski HJ, Porter JD. 2003. Molecular organization of the extraocular muscle neuromuscular junction: partial conservation of and divergence from the skeletal muscle prototype. Invest Ophthalmol Vis Sci 44:1918-1926.
13. Kong J, Anderson JE. 1999. Dystrophin is required for organizing large acetylcholine receptor aggregates. Brain Res 839:298-304.
14. Krurana TS, Predergast RA, Alameddine HS, Tome FM, Farden M, Arahata K, Sugita H, Kunkel LM. 1995. Absence of extraocular muscle pathology in Duchenne's muscular dystrophy: role for calcium homeostasis in extraocular muscle sparing. J Exp Med 182:467-474.
15. Lyons PR, Slater CR. 1991. Structure and function of the neuromuscular junction in young adult mdx mice. J Neurocytol 20:969-981.
16. Marques MJ, Santo Neto H. 1998. Imaging neuromuscular junctions by confocal fluorescence microscopy: individual endplates seen in whole muscles with vital intracellular staining of the nerve terminals. J Anat 192:425-430.
17. Marques MJ, Conchello JA, Lichtman JW. 2000. From plaque to pretzel: fold formation and acetylcholine receptor loss at the developing neuromuscular junction. J Neurosci 20:3663-3675.
18. Marques MJ, Mendes ZTR, Minatel E, Santo Neto H. 2005. Acetylcholine receptors and nerve terminal distribution at the neuromuscular junction of long-term regenerated muscle fibers. J Neurocytol 34:387-396.
19. Marques MJ, Taniguti AP, Minatel E, Santo Neto H. 2007. Nerve terminal contributes to acetylcholine receptor organization at the dystrophic neuromuscular junction of mdx mice. Anat Rec 290:181-187.
20. Minatel E, Santo Neto H, Marques MJ. 2001. Acetylcholine receptors and neuronal nitric oxide synthase distribution at the neuromuscular junction of regenerated muscle fibers. Muscle Nerve 24:410-416.
21. Minatel E, Santo Neto H, Marques MJ. 2003. Acetylcholine receptor distribution and synapse elimination at the developing neuromuscular junction of mdx mice. Muscle Nerve 28:561-569.
22. Pastoret C, Sebille A. 1995. Mdx mice show progressive weakness and muscle deterioration with age. J Neurol Sci 129:97-105.
23. Personius KE, Sawyer RP. 2005. Terminal Schwann cell structure is altered in diaphragm of mdx mice. Muscle Nerve 32:656-663.
24. Porter JD, Baker RS. 1996. Muscles of a different color: the unusual properties of the extraocular muscles may predispose or protect them in neurogenic and myogenic disease. Neurology 46:30-37.
25. Porter JD, Rafael JA, Ragusa RJ, Brueckner JK, Trickett JI, Davies KE. 1998. The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophin. J Cell Sci 111:1801-1811.
26. Porter JD, Merlam AP, Khanna S, Andrade FH, Richmonds CR, Leahy P, Cheng G, Karathanasis P, Zhou X, Kusner LL, Adams ME, Willem M, Mayer U, Kaminski HJ. 2003. Constitutive properties, not molecular adaptations, mediate extraocular muscle sparing in dystrophic mdx mice. FASEB J 17:893-895.
27. Rando TA. 2001. The dystrophin-glycoprotein complex, cellular signaling, and the regulation of cell survival in the muscular dystrophies. Muscle Nerve 24:1575-1594.
28. Rich M, Lichtman JW. 1989. Motor nerve terminal loss from degenerating muscle fibers. Neuron 3:677-688.
29. Santo Neto H, Martins JA, Minatel E, Marques MJ. 2003. Axonal sprouting in mdx mice and its relevance to cell and gene mediated therapies for Duchenne muscular dystrophy. Neurosci Lett 343:67-69.
30. Shiao T, Fond A, Deng B, Wehling-Henricks M, Adams ME, Froehner SC, Tidball JG. 2004. Defects in neuromuscular junction structure in dystrophic muscle are corrected by expression of a NOS transgene in dystrophin-deficient muscles, but not in muscles lacking α- and β1-syntrophins. Hum Mol Genet 13:1873-1884.
31. Spencer RF, Porter JD. 1988. Structural organization of the extraocular muscles. In: Buttner-Ennever JA, editor. Reviews in oculomotor research. New York: Elsevier. p 33-79.
32. Torres LF, Duchen LW. 1987. The mutant mdx: inherited myopathy in the mouse. Morphological studies of nerves, muscle and endplates. Brain 110:269-299.
33. Xu R, Salpeter M. 1997. Acetylcholine receptors in innervated muscles of dystrophic mdx mice degrade as after denervation. J Neurosci 17:8194-8200.
34. Wehling M, Stull JT, McCabe TJ, Tidball JG. 1998. Sparing of mdx extraocular muscles from dystrophic pathology is not attributable to normalized concentration or distribution of neuronal nitric oxide synthase. Neuromuscul Disord 8:22-29.