Acetylcholine receptors in innervated muscles of dystrophic mdx mice degrade as after denervation

Journal of Neuroscience

Volumn 17, Issue 21, 1997, Pages 8194-8200

  Xu, Rufeng ^a,b   Salpeter, Miriam M ^a  

^a Department of Obstetrics Gynecology   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cAMP; Diaphragm; Forskolin; Soleus; Sternomastoid; Turnover

Indexed keywords

CHOLINERGIC RECEPTOR; DYSTROPHIN;

ACETYLCHOLINE RELEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DENERVATION; FEMALE; HEREDITARY SPINAL MUSCULAR ATROPHY; MOUSE; MUSCLE INNERVATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RECEPTOR DENSITY; STRAIN DIFFERENCE;

EID: 0030785497     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-21-08194.1997     Document Type: Article

References (20)

1. Andrcose JS, Xu R, Lmo T, Salpeter MM, Fumagalli G (1993) Degradation of two AChR populations at rat neuromuscular junction: regulation in vivo by electrical stimulation. J Neurosci 13:3433-3438.
2. Apel ED, Merlie JP (1995) Assembly of the postsynaptic apparatus. Curr Opin Neurobiol 5:62-67.
3. Apel ED, Roberds SL, Campbell KP, Merlie JP (1995) Rapsyn may function as a link between the acetylcholine receptor and the agrinbinding dystrophin-associated glycoprotein complex. Neuron 15:115-126.
4. Avila OL, Drachman DB, Pestronk A (1989) Neurotransmission regulates stability of acetylcholine receptors at the neuromuscular junction. J Neurosci 9:2902-2906.
5. Bevan S, Steinbach H (1983) Denervation increases the degradation rate of acetylcholine receptors at end-plate in vivo and in vitro. J Physiol (Lond) 336:159-177.
6. Bewick GS, Nicholson LVB, Young C, O'Donnell E, Slater CR (1992) Different distribution of dystrophin and related proteins at nervemuscle junctions. NeuroReport 3:857-860.
7. Bloch RJ, Morrow JS (1989) An unusual β-spectrin associated with clustered acetylcholine receptors. J Cell Biol 108:481-493.
8. Bloch RJ, Pumplin DW (1988) Molecular events in synapto-genesis: nerve-muscle adhesion and postsynaptic differentiation. Am J Physiol 254:C345-C364.
9. Bloch RJ, Resneck WG, O'Neill A, Strong J, Pumplin DW (1991) Cytoplasmic components of acetylcholine receptor clusters of cultured rat myotubes: the 58 kDa protein. J Cell Biol 115:435-446.
10. Burden SJ, Depalma RL, Gottesman GS (1983) Crossing of proteins in acetylcholine receptor-rich membranes: association between the βsubunit and the 43 kd subsynaptic protein. Cell 35:687-692.
11. Byers TJ, Kunkel LM, Watkins SC (1991) The subcellular distribution of dystrophin in mouse skeletal, cardiac, and smooth muscle. J Cell Biol 115:411-421.
12. Caldero J, Casanovas A, Sorribas A, Esquerda JE (1992) Calcitonin gene-related peptide in rat spinal cord motoneurons: subcellular distribution and changes induced by axotomy. Neuroscience 48:449-461.
13. Crook RB, Yabu JM (1992) Calcitonin gene-related peptide stimulates intracellular cAMP via a protein kinase C-controlled mechanism in human ocular ciliary epithelial cells. Biochem Biophys Res Commun 188:662-670.
14. Dickson G, Azad A, Morris GE, Simon H, Noursadeghi M, Walsh FS (1992) Co-localization, molecular association of dystrophin with laminin at the surface of mouse and human myotubes. J Cell Sci 103:1223-1233.
15. Ervasti JM, Campbell KP (1991) Membrane organization of the dystrophin-glycoprotein complex. Cell 66:1121-1131.
16. Fambrough DM (1979) Control of acetylcholine receptors in skeletal muscle. Physiol Rev 59:165-227.
17. 125I-labeled α-bungarotoxin binding at mouse motor endplates. Proc Natl Acad Sci USA 71:1376-1378.
18. Froehner SC (1986) The role of the postsynaptic cytoskeleton in acetylcholine receptor organization. Trends Neurosci 9:37-41.
19. Froehner SC, Murnane AA, Tobler M, Peng HB, Sealock R (1987) A postsynaptic Mr 58,000 (58K) protein concentrated at acetylcholine receptor rich sites in Torpedo electroplaques and skeletal muscle. J Cell Biol 104:1633-1646.
20. Fumagalli G, Balbi S, Cangiano A, Lømo T (1990) Regulation of turnover and number of acetylcholine receptors at neuromuscular junction. Neuron 4:563-569.