Inhibitory effect of peroxisome proliferator-activated receptor-γ ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39

Biochemical and Biophysical Research Communications

Volumn 295, Issue 2, 2002, Pages 547-552

  Miyazaki, Yoshiyuki ^a   Tachibana, Hirofumi ^a   Yamada, Koji ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Class switch recombination; Germline transcription; IgE; PPAR ; STAT6

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; CIGLITAZONE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN HEAVY CHAIN; INTERLEUKIN 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; STAT6 PROTEIN;

ARTICLE; B LYMPHOCYTE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG RECEPTOR BINDING; GENE SWITCHING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

B-LYMPHOCYTES; CELL LINE; GERM CELLS; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN HEAVY CHAINS; INTERLEUKIN-4; LIGANDS; PHOSPHORYLATION; PROSTAGLANDIN D2; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER; STAT6 TRANSCRIPTION FACTOR; THIAZOLES; THIAZOLIDINEDIONES; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0036062664     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00709-X     Document Type: Article

References (38)

1. The allergy and asthma
2. The role of immunoglobulin E in allergy and asthma
3. Induction and regulation of the IgE response
4. Rearrangement of immunoglobulin γ1-chain gene and mechanism for heavy-chain class switch
5. Exon suffling generates and immunoglobulin heavy chain gene
6. Specificity of immunoglobulin heavy chain switch correlates with activity of germline heavy chain genes prior to switching
7. Regulation of the IgE isotype switch: New insights on cytokine signals and the functions of ε germline transcripts
8. Structure and expression of germline epsilon transcripts in human B cells induced by interleukin 4 to switch to IgE production
9. Interleukin 4 activates a signal transducer and activator of transcription (Stat) protein which interacts with an interferon-γ activation site-like sequence upstream of the Iε exon in a human B cell line
10. Essential role of Stat6 in IL-4 signalling
11. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
12. Nuclear receptors and lipid physiology: Opening the X-files
13. Peroxisome proliferator-activated receptors: Nuclear control of metabolism
14. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors
15. Differential activation of peroxisome proliferator-activated receptors by eicosanoids
16. 2 is a ligand for the adipocyte determination factor PPAR gamma
17. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the anti-hyperglycemic activity of thiazolidinediones
18. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
19. Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells
20. Nuclear receptor peroxisome proliferator-activated receptor α (PPARα) is expressed in resting murine lymphocytes
21. 2 induce apoptosis in normal and malignant B-lineage cells
22. The effect of cytokines and mitogens on the induction of Cε germline transcripts in a human Burkitt lymphoma B cell line
23. Concanavalin A stimulation enhanced secondary VλJλ rearrangement in some human plasma B cells without up-regulation of recombination-activating gene expression and Vλ germline transcription
24. Peroxisome proliferator-activated receptor-γ haploinsufficiency enhances B cell proliferative responses and exacerbates experimentally induced arthritis
25. Requirement of tyrosine phosphory-lation for rapid activation of a DNA binding factor by IL-4
26. Components of a Stat recognition code: Evidence for two layers of molecular selectivity
27. SH2 domains recognize specific phosphopeptide sequences
28. IL-4/IL-13 signaling beyond JAK/STAT
29. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
30. Negative regulation of the JAK/STAT pathway
31. Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction
32. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
33. Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-α (PPARα) signaling pathways
34. STAT5b down-regulates peroxisome proliferator-activated receptor α transcription by inhibition of ligand-independent activation function region-1 trans-activation domain
35. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
36. 2 inhibits multiple steps in the NF-κB signaling pathway
37. PPAR-γ dependent independent effects on macrophage-gene expression in lipid metabolism and inflammation
38. A thiol antioxidant regulates IgE isotype switching by inhibiting activation of nuclear factor-κB