The use of microdialysis for the study of drug kinetics: Central nervous system pharmacokinetics of diphenhydramine in fetal, newborn, and adult sheep

Drug Metabolism and Disposition

Volumn 35, Issue 8, 2007, Pages 1285-1291

  Au Yeung, Sam C S ^a   Riggs, K Wayne ^b   Gruber, Nancy ^c   Rurak, Dan W ^c  

^a IQVIA   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHENHYDRAMINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ABSORPTION; DRUG DIFFUSION; DRUG PROTEIN BINDING; EXTRACELLULAR FLUID; FEMALE; FETUS; GROUPS BY AGE; LAMB; LOADING DRUG DOSE; MICRODIALYSIS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SHEEP; STATISTICAL SIGNIFICANCE;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; AREA UNDER CURVE; BLOOD PROTEINS; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; DIPHENHYDRAMINE; EXTRACELLULAR FLUID; FEMALE; FETUS; HISTAMINE H1 ANTAGONISTS; INFUSIONS, INTRAVENOUS; MICRODIALYSIS; SHEEP;

OVIS ARIES;

EID: 34547166540     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.013995     Document Type: Article

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