Venous leg ulcers - The search for a prognostic indicator

International Wound Journal

Volumn 4, Issue 2, 2007, Pages 163-172

  Moore, Keith ^a   Huddleston, Elizabeth ^b   Stacey, Michael C ^c   Harding, Keith G ^d  

^a WoundSci   (United Kingdom)

^b Smith and Nephew Research Centre   (United Kingdom)

^c UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^d CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Chronic wound; Diagnostic test; Healing outcome; Prognostic test; Venous leg ulcer

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; PROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; CHRONIC WOUND; DISEASE COURSE; HEALING; HUMAN; LEG ULCER; MICROBIOLOGY; MOLECULE; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; SENESCENCE; VALIDATION STUDY; WOUND ASSESSMENT; WOUND FLUID;

EID: 34547102210     PISSN: 17424801     EISSN: 1742481X     Source Type: Journal    
DOI: 10.1111/j.1742-481X.2007.00335.x     Document Type: Article

References (74)

1. Ruckley CV. Socioeconomic impact of chronic venous insufficiency and leg ulcers. Angiology 1997 48 : 67 9.
2. Franks PJ, Moffatt CJ, Connolly M, Bosanquet N, Oldroyd MI, Greenhalgh RM, McCollum CN. Factors associated with healing leg ulceration with high compression. Age Ageing 1995 24 : 407 10.
3. Margolis DJ, Allen-Taylor L, Hoffstad O, Berlin JA. The accuracy of venous leg ulcer prognostic models in a wound care system. Wound Repair Regen 2004 12 : 163 8.
4. Kantor J, Margolis DJ. A multicentre study of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks. Br J Dermatol 2000 142 : 960 4.
5. Flanagan M. Wound measurement: can it help us to monitor progression to healing? J Wound Care 2003 12 : 189 94.
6. Mani R. Science of measurements in wound healing. Wound Repair Regen 1999 7 : 330 4.
7. Linblad WJ. How sophisticated do we need to be. Wound Repair Regen 1999 7 : 329.
8. Dyson M, Young S, Pendle CL, Webster DF, Lang SM. Comparison of the effects of moist and dry conditions on dermal repair. J Invest Dermatol 1998 91 : 435 9.
9. Berry DP, Harding KG, Stanton MR, Jasani B, Ehrlich P. Human wound contraction: collagen organization, fibroblasts, and myofibroblats. Plast Reconstr Surg 1998 102 : 124 31.
10. Loots MA, Lamme EN, Zeegelaar J, Mekkes JR, Bos JD, Middelkoop E. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol 1998 111 : 850 7.
11. Moore K, Ruge F, Harding KG. T-lymphocytes and the lack of activated macrophages in wound margin biopsies from chronic leg ulcers. Br J Dermatol 1997 137 : 188 94.
12. Rosner K, Ross C, Karlsmark T, Petersen AA, Gottrup F, Vejlsgaard GL. Immunohistochemical characterization of the cutaneous cellular infiltrate in different areas of chronic leg ulcers. APMIS 1995 103 : 293 9.
13. Weller K, Foitzik K, Paus R, Syska W, Maurer M. Mast cells are required for normal healing of skin wounds in mice. FASEB J 2006 20 : 2366 8.
14. Huttunen M, Aalto ML, Harvima RJ, Horsmanheimo M, Harvima IT. Alterations in mast cells showing tryptase and chymase activity in epithelializating and chronic wounds. Exp Dermatol 2000 9 : 258 65.
15. Hahn J, Junger M, Friedrich B, Zuder D, Steins A, Hahn M, Klyscz T. Cutaneous inflammation limited to the region of the ulcer in chronic venous insufficiency. VASA 1997 26 : 277 81.
16. Weyl A, Vanscheidt W, Weiss JM, Peschen M, Schopf E, Simon J. Expression of the adhesion molecules ICAM-1, VCAM-1, and E-selectin and their ligands VLA-4 and LFA-1 in chronic venous leg ulcers. J Am Acad Dermatol 1996 34 : 418 23.
17. Higley HR, Ksander GA, Gerhardt CO, Falanga V. Extravasation of macromolecules and possible trapping of transforming growth factor-beta in venous ulceration. Br J Dermatol 1995 132 : 79 85.
18. O'Connor-McCourt MD, Wakefield LM. Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin. J Biol Chem 1987 262 : 14090 9.
19. Balslev E, Thomsen HK, Danielsen L, Sheller J, Garred P. The terminal complement complex is generated in chronic leg ulcers in the absence of protectin (CD59). APMIS 1999 107 : 997 1004.
20. Davies A, Lachmann PJ. Membrane defence against complement lysis: the structure and biological properties of CD59. Immunol Res 1993 12 : 258 75.
21. Abd-El-Aleem SA, Ferguson MW, Appleton I, Bhowmick A, McCollum CN, Ireland GW. Expression of cyclooxygenase isoforms in normal human skin and chronic venous ulcers. J Pathol 2001 195 : 616 23.
22. Luk PP, Sinha SN, Lord R. Upregulation of inducible nitric oxide synthase (iNOS) expression in faster-healing chronic leg ulcers. J Wound Care 2005 14 : 373 5, 378 81.
23. Cowin AJ, Hatzirodos N, Holding CA, Dunaiski V, Harries RH, Rayner TE, Fitridge R, Cooter RD, Schultz GS, Belford DA. Effect of healing on the expression of transforming growth factor beta(s) and their receptors in chronic venous leg ulcers. J Invest Dermatol 2001 117 : 1282 9.
24. Claudy AL, Mirshahi M, Soria C, Soria J. Detection of undegraded fibrin and tumor necrosis factor-alpha in venous leg ulcers. J Am Acad Dermatol 1991 25 : 623 7.
25. Norgauer J, Hildenbrand T, Idzko M, Panther E, Bandemir E, Hartmann M, Vanscheidt W, Herouy Y. Elevated expression of extracellular matrix metalloproteinase inducer (CD147) and membrane-type matrix metalloproteinases in venous leg ulcers. Br J Dermatol 2002 147 : 1180 6.
26. Vaalamo M, Weckroth M, Puolakkainen P, Kere J, Saarinen P, Lauharanta J, Saarialho-Kere UK. Patterns of matrix metalloproteinase and TIMP-1 expression in chronic and normally healing human cutaneous wounds. Br J Dermatol 1996 135 : 52 9.
27. Herouy Y, Trefzer D, Hellstern MO, Stark GB, Vanscheidt W, Schopf E, Norgauer J. Plasminogen activation in venous leg ulcers. Br J Dermatol 2000 143 : 930 6.
28. Clark RA, Folkvord JM, Wertz RL. Fibronectin, as well as other extracellular matrix proteins, mediate human keratinocyte adherence. J Invest Dermatol 1985 84 : 378 83.
29. Herrick SE, Sloan P, McGurk M, Freak L, McCollum CN, Ferguson MW. Sequential changes in histologic pattern and extracellular matrix deposition during the healing of chronic venous ulcers. Am J Pathol 1992 141 : 1085 95.
30. Tarlton JF, Bailey AJ, Crawford E, Jones D, Moore K, Harding KD. Prognostic value of markers of collagen remodeling in venous ulcers. Wound Repair Regen 1999 7 : 347 55.
31. Staiano-Coico L, Higgins PJ, Schwartz SB, Zimm AJ, Goncalves J. Wound fluids: a reflection of the state of healing. Ostomy Wound Manage 2000 46 (1A Suppl 85 93S
32. Grinnell F, Ho CH, Wysocki A. Degradation of fibronectin and vitronectin in chronic wound fluid: analysis by cell blotting, immunoblotting, and cell adhesion assays. J Invest Dermatol 1992 98 : 410 6.
33. Agren MS. Gelatinase activity during wound healing. Br J Dermatol 1994 131 : 634 40.
34. Bullen EC, Longaker MT, Updike DL, Benton R, Ladin D, Hou Z, Howard EW. Tissue inhibitor of metalloproteases-1 is decreased and activated gelatinases are increased in chronic wounds. J Invest Dermatol 1995 104 : 236 40.
35. Trengove NJ, Stacey MC, MacAuley S, Bennett N, Gibson J, Burslem F, Murphy G, Schultz G. Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Repair Regen 1999 7 : 442 52.
36. Stacey MC, Mata SD. Lower levels of PAI-2 may contribute to impaired healing in venous ulcers - a preliminary study. Cardiovasc Surg 2000 8 : 381 5.
37. Wysocki AB, Kusakabe AO, Chang S, Tuan TL. Temporal expression of urokinase plasminogen activator, plasminogen activator inhibitor and gelatinase-B in chronic wound fluid switches from a chronic to acute wound profile with progression to healing. Wound Repair Regen 1999 7 : 154 65.
38. Camussi G, Albano E, Tetta C, Bussolino F. The molecular action of tumor necrosis factor-alpha. Eur J Biochem 1991 202 : 3 14.
39. Wallace HJ, Stacey MC. Levels of tumor necrosis factor-alpha (TNF-alpha) and soluble TNF receptors in chronic venous leg ulcers- correlations to healing status. J Invest Dermatol 1998 110 : 292 6.
40. Li YQ, Doyle JW, Roth TP, Dunn RM, Lawrence WT. IL-10 and GM-CSF expression and the presence of antigen-presenting cells in chronic venous ulcers. J Surg Res 1998 79 : 128 35.
41. Fivenson DP, Faria DT, Nickoloff BJ, Poverini PJ, Kunkel S, Burdick M, Strieter RM. Chemokine and inflammatory cytokine changes during chronic wound healing. Wound Repair Regen 1997 5 : 310 22.
42. Harris IR, Yee KC, Walters CE, Cunliffe WJ, Kearney JN, Wood EJ, Ingham E. Cytokine and protease levels in healing and non-healing chronic venous leg ulcers. Exp Dermatol 1995 4 : 342 9.
43. Phillips TJ, al-Amoudi HO, Leverkus M, Park HY. Effect of chronic wound fluid on fibroblasts. J Wound Care 1998 7 : 527 32.
44. Jalkanen M, Haapanen T, Lyytikainen AM, Larjava H. Wound fluids mediate granulation tissue growth phases. Cell Biol Int Rep 1983 7 : 745 53.
45. Gartner MH, Shearer JD, Bereiter DF, Mills CD, Caldwell MD. Wound fluid amino acid concentrations regulate the effect of epidermal growth factor on fibroblast replication. Surgery 1991 110 : 448 55.
46. Trengove NJ, Stacey MC, McGechie DF, Mata S. Qualitative bacteriology and leg ulcer healing. J Wound Care 1996 5 : 277 80.
47. Stolle LB, Riegels-Nielsen P. The metabolism of the diabetic foot: in vivo investigation with microdialysis. Acta Orthop Scand 2004 75 : 106 8.
48. Nemeth AJ, Eaglstein WH, Falanga V. Clinical parameters and transcutaneous oxygen measurements for the prognosis of venous ulcers. J Am Acad Dermatol 1989 20 : 186 90.
49. Wlaschek M, Scharffetter-Kochanek K. Oxidative stress in chronic venous leg ulcers. Wound Repair Regen 2005 13 : 452 61.
50. Wenk J, Foitzik A, Achterberg V, Sabiwalsky A, Dissemond J, Meewes C, Reitz A, Brenneisen P, Wlaschek M, Meyer-Ingold W, Scharffetter-Kochanek K. Selective pick-up of increased iron by deferoxamine-coupled cellulose abrogates the iron-driven induction of matrix-degrading metalloproteinase 1 and lipid peroxidation in human dermal fibroblasts in vitro: a new dressing concept. J Invest Dermatol 2001 116 : 833 9.
51. Yeoh-Ellerton S, Stacey MC. Iron and 8-isoprostane levels in acute and chronic wounds. J Invest Dermatol 2003 121 : 918 25.
52. James TJ, Hughes MA, Cherry GW, Taylor RP. Simple biochemical markers to assess chronic wounds. Wound Repair Regen 2000 8 : 264 9.
53. James TJ, Hughes MA, Cherry GW, Taylor RP. Evidence of oxidative stress in chronic venous ulcers. Wound Repair Regen 2003 11 : 172 6.
54. Moseley R, Hilton JR, Waddington RJ, Harding KG, Stephens P, Thomas DW. Comparison of oxidative stress biomarker profiles between acute and chronic wound environments. Wound Repair Regen 2004 12 : 419 29.
55. Wipke-Tevis DD, Stotts NA. Nutritional risk, status, and intake of individuals with venous ulcers: a pilot study. J Vasc Nurs 1996 14 : 27 33.
56. Campisi J. The role of cellular senescence in skin aging. J Invest Dermatol Symp Proc 1998 3 : 1 5.
57. Chen J-H, Stoeber K, Kingsbury S, Ozanne SE, Williams GH, Hales CN. Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J Biol Chem 2004 47 : 49439 46.
58. Dumont P, Balbeur L, Remacle J, Toussaint O. Appearance of biomarkers of in vitro ageing after successive stimulation of WI-38 fibroblasts with IL-1alpha and TNF-alpha: senescence associated beta-galactosidase activity and morphotype transition. J Anat 2000 197 : 529 37.
59. Mendez MV, Stanley A, Park HY, Shon K, Phillips T, Menzoian JO. Fibroblasts cultured from venous ulcers display cellular characteristics of senescence. J Vasc Surg 1998 28 : 876 83.
60. Raffetto JD, Mendez MV, Phillips TJ, Park HY, Menzoian JO. The effect of passage number on fibroblast cellular senescence in patients with chronic venous insufficiency with and without ulcer. Am J Surg 1999 178 : 107 12.
61. Stanley A, Osler T. Senescence and the healing rates of venous ulcers. J Vasc Surg 2001 33 : 1206 11.
62. Bowler PG, Duerden BI, Armstrong DG. Wound microbiology and associated approaches to wound management. Clin Microbiol Rev 2001 14 : 244 69.
63. Hansson C, Hoborn J, Moller A, Swanbeck G. The microbial flora in venous leg ulcers without clinical signs of infection. Repeated culture using a validated standardised microbiological technique. Acta Derm Venereol 1995 75 : 24 30.
64. Kingsley A. The wound infection continuum and its application to clinical practice. Ostomy Wound Manage 2003 49 (7A Suppl 1 7.
65. Gradon J, Adamson C. Infections of pressure ulcers: management and controversies. Infect Dis Clin Pract 1995 1 : 11 6.
66. Bowler P. The anaerobic and aerobic microbiology of wounds: a review. Wounds 1998 10 : 170 8.
67. Bowler PG, Davies BJ. The microbiology of infected and noninfected leg ulcers. Int J Dermatol 1999 38 : 573 8.
68. Robson MC, Mannari RJ, Smith PD, Payne WG. Maintenance of wound bacterial balance. Am J Surg 1999 178 : 399 402.
69. Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM. Microbial biofilms. Annu Rev Microbiol 1995 49 : 711 45.
70. Foster WD. Pathology as a profession in Great Britain. London : Royal College of Pathologists, 1981.
71. Tierney MJ, Tamada JA, Potts RO, Jovanovic L, Garg S. Clinical evaluation of the GlucoWatch biographer: a continual, non-invasive glucose monitor for patients with diabetes. Biosens Bioelectron 2001 16 : 621 9.
72. Moore K, McCallion R, Searle RJ, Stacey MC, Harding KG. Prediction and monitoring of the therapeutic response of chronic dermal wounds. Int Wound J 2006 3 : 89 96.
73. Cullen B. Wound monitoring. International Patent Publication No WO 03/040406, 2003.
74. Drinkwater SL, Burnand KG, Ding R, Smith A. Increased but ineffectual angiogenic drive in nonhealing venous leg ulcers. J Vasc Surg 2003 38 : 1106 12.