The absorption behavior of cyclosporin A lecithin vesicles in rat intestinal tissue

International Journal of Pharmaceutics

Volumn 261, Issue 1-2, 2003, Pages 21-26

  Chen, Ying ^a   Ping, Qineng ^a   Guo, Jianxin ^a   Lv, Wenli ^a   Gao, Jing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Absorption behavior; Cyclosporin A; Everted gut sac technique; In situ circulation method; Lecithin vesicles

Indexed keywords

CYCLOSPORIN A; PHOSPHATIDYLCHOLINE; PROTEIN INHIBITOR; SANDIMMUM NEORAL; SODIUM ION;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG DIFFUSION; DRUG FORMULATION; ENERGY; EVAPORATION; INTESTINE; INTESTINE MUCOSA; MICROEMULSION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; ULTRASOUND; VELOCITY;

EID: 0043028198     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00274-6     Document Type: Article

References (10)

1. Barthe L., Bessouet M., Woodley J.F. The improved everted gut sac: a simple method to study intestinal P-glycoprotein. Int. J. Pharm. 173:1998;255-258.
2. Barthe L., Woodley J., Houin G. Gastrointestinal absorption of drugs: methods and studies. Fundam. Clin. Pharmacol. 13:1999;154-168. Review.
3. Chaing C.M., Weiner N. Gastrointestinal uptake of liposomes. I. In vitro and in situ studies. Int. J. Pharm. 37:1987;75-85.
4. Chen H.M., Langer R. Oral particulate delivery: status and future trends. Adv. Drug. Del. Rev. 34:1998;339-350.
5. Fagerholm U., Johansson M., Lennernats H. Comparison between permeability coefficients in rat and human jejunum. Pharm. Res. 13:1996;1336-1342.
6. Guo J.X., Ping Q.N., Chen Y. Pharmacokinetic behavior of cyclosporin A in rabbits by oral administration of lecitin vesicle and sanimmun neoral. Int. J. Pharm. 216:2001;17-21.
7. Klompmaker I.J., Wierda J.M.K.H., Sluiter W.J., Uages D.R.A., Haagsma E.B., Verwer R., Slooff M.J.H. Pharmacokinetics of cyclosporin A after intravenous and oral administration in liver transplant patients measured with high-performance liquid chromatography. Ther. Drug Monit. 15:1993;60-63.
8. Kovarik J.M., Mueller E.A., Van Bree J.B., Tetzloff W., Kuta K. Reduced inter- and intra-individual variability in cyclosporine pharmacokinetics from a microemulsion formulation. J. Pharm. Sci. 83:1994;444-446.
9. Rowland R.N., Woodley J.F. The uptake of distearoylphosphatidylcholine/cholesterol liposomes by rat intestinal sac in vitro. Biochim. Biophys. Acta. 673:1981;217-223.
10. Tu, X., 1998. Biopharmaceuticals, China Health Science & Technology Press, Beijing.