Complexation of phenytoin with some hydrophilic cyclodextrins: Effect on aqueous solubility, dissolution rate, and anticonvulsant activity in mice

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 52, Issue 1, 2001, Pages 65-73

  Latrofa, A ^a   Trapani, G ^a   Franco, M ^a   Serra, M ^b   Muggironi, M ^b   Fanizzi, F P ^a,c   Cutrignelli, A ^a   Liso, G ^a  

^a UNIVERSITY OF BARI   (Italy)

^b Sezione di Neuroscienze   (Italy)

^c CARSO Cancer Research Center   (Italy)

Author keywords

Dissolution rate; Hydroxypropylated cyclodextrin; Hydroxypropylated cyclodextrin; Inclusion complexation; Maximal electroshock test; Methyl cyclodextrin; Phenytoin (DPH); Water solubility

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; CYCLODEXTRIN; CYCLODEXTRIN DERIVATIVE; METHYL BETA CYCLODEXTRIN; PHENYTOIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; DRUG STABILITY; ELECTRIC SHOCK; INFRARED SPECTROSCOPY; MALE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SEIZURE; X RAY DIFFRACTION;

ANIMALS; ANTICONVULSANTS; CYCLODEXTRINS; DRUG STABILITY; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; PHENYTOIN; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; X-RAY DIFFRACTION;

EID: 0034951481     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(01)00144-8     Document Type: Article

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