Chronic lamotrigine does not alter the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat: Implications for the treatment of bipolar disorder

Psychopharmacology

Volumn 193, Issue 4, 2007, Pages 467-474

  Lee, Ho Joo ^a   Rao, Jagadeesh S ^a   Chang, Lisa ^a   Rapoport, Stanley I ^a   Bazinet, Richard P ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Arachidonic acid; Bipolar disorder; Brain; Lamotrigine; Phospholipids; Rat; Turnover

Indexed keywords

ARACHIDONIC ACID; CARBON 14; FATTY ACID; LAMOTRIGINE; PHOSPHOLIPID; TRACER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL BLOOD; ARTICLE; BIPOLAR DISORDER; BLOOD SAMPLING; CHEMICAL ANALYSIS; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DOWN REGULATION; FATTY ACID METABOLISM; HYPOTHESIS; MALE; MICROWAVE RADIATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ACYL COENZYME A; ANIMALS; ANTIMANIC AGENTS; ARACHIDONIC ACID; BIPOLAR DISORDER; BRAIN; DISEASE MODELS, ANIMAL; DOWN-REGULATION; GAMMA-AMINOBUTYRIC ACID; MALE; PHOSPHOLIPIDS; RANDOM ALLOCATION; RATS; RATS, INBRED F344; TRIAZINES;

EID: 34447630843     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-007-0803-2     Document Type: Article

References (71)

1. Ahmad S, Fowler LJ, Whitton PS (2004) Effect of acute and chronic lamotrigine on basal and stimulated extracellular 5-hydroxytryptamine and dopamine in the hippocampus of the freely moving rat. Br J Pharmacol 142:136-142
2. Ahmad S, Fowler LJ, Whitton PS (2005a) Effects of combined lamotrigine and valproate on basal and stimulated extracellular amino acids and monoamines in the hippocampus of freely moving rats. Naunyn Schmiedebergs Arch Pharmacol 371:1-8
3. Ahmad S, Fowler LJ, Whitton PS (2005b) Lamotrigine, carbamazepine and phenytoin differentially alter extracellular levels of 5-hydroxytryptamine, dopamine and amino acids. Epilepsy Res 63:141-149
4. Aveldano MI, VanRollins M, Horrocks LA (1983) Separation and quantitation of free fatty acids and fatty acid methyl esters by reverse phase high pressure liquid chromatography. J Lipid Res 24(1):83-93
5. Axelrod J (1990) Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction. Biochem Soc Trans 18:503-507
6. Basselin M, Chang L, Bell JM, Rapoport SI (2005a) Chronic lithium chloride administration to unanesthetized rats attenuates brain dopamine D2-like receptor-initiated signaling via arachidonic acid. Neuropsychopharmacology 30:1064-1075
7. Basselin M, Chang L, Seemann R, Bell JM, Rapoport SI (2005b) Chronic lithium administration to rats selectively modifies 5-HT2A/2C receptor-mediated brain signaling via arachidonic acid. Neuropsychopharmacology 30:461-472
8. Basselin M, Chang L, Bell JM, Rapoport SI (2006) Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats. Neuropsychopharmacology 31:1659-1674
9. Bazinet RP, Lee HJ, Felder CC, Porter AC, Rapoport SI, Rosenberger TA (2005a) Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain. Neurochem Res 30:597-601
10. Bazinet RP, Rao JS, Chang L, Rapoport SI, Lee HJ (2005b) Chronic valproate does not alter the kinetics of docosahexaenoic acid within brain phospholipids of the unanesthetized rat. Psychopharmacology (Berl) 182:180-185
11. Bazinet RP, Rao JS, Chang L, Rapoport SI, Lee HJ (2006a) Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: relevance to bipolar disorder. Biol Psychiatry 59:401-407
12. Bazinet RP, Weis MT, Rapoport SI, Rosenberger TA (2006b) Valproic acid selectively inhibits conversion of arachidonic acid to arachidonoyl-CoA by brain microsomal long-chain fatty acyl-CoA synthetases: relevance to bipolar disorder. Psychopharmacology (Berl) 184:122-129
13. Bazinet RP, Bhattacharjee AK, Lee HJ (2007) Haloperidol targets brain arachidonic acid signaling. Prog Neuropsychopharmacol Biol Psychiatry 31:314-315
14. Bhattacharjee AK, Chang L, Lee HJ, Bazinet RP, Seemann R, Rapoport SI (2005) D2 but not D1 dopamine receptor stimulation augments brain signaling involving arachidonic acid in unanesthetized rats. Psychopharmacology (Berl) 180:735-742
15. Bhattacharjee AK, Chang L, White L, Bazinet RP, Rapoport SI (2006) d-Amphetamine stimulates D2 dopamine receptor-mediated brain signaling involving arachidonic acid in unanesthetized rats. J Cereb Blood Flow Metab 26:1378-1388
16. Bosetti F, Rintala J, Seemann R, Rosenberger TA, Contreras MA, Rapoport SI, Chang MC (2002a) Chronic lithium downregulates cyclooxygenase-2 activity and prostaglandin E(2) concentration in rat brain. Mol Psychiatry 7:845-850
17. Bosetti F, Seemann R, Bell JM, Zahorchak R, Friedman E, Rapoport SI, Manickam P (2002b) Analysis of gene expression with cDNA microarrays in rat brain after 7 and 42 days of oral lithium administration. Brain Res Bull 57:205-209
18. Bosetti F, Weerasinghe GR, Rosenberger TA, Rapoport SI (2003) Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain. J Neurochem 85:690-696
19. Bourre JM, Dumont OL, Clement ME, Durand GA (1997) Endogenous synthesis cannot compensate for absence of dietary oleic acid in rats. J Nutr 127:488-493
20. Bowden CL, Calabrese JR, Sachs G, Yatham LN, Asghar SA, Hompland M, Montgomery P, Earl N, Smoot TM, DeVeaugh-Geiss J (2003) A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently manic or hypomanic patients with bipolar I disorder. Arch Gen Psychiatry 60:392-400
21. Calabrese JR, Bowden CL, Sachs G, Yatham LN, Behnke K, Mehtonen OP, Montgomery P, Ascher J, Paska W, Earl N, DeVeaugh-Geiss J (2003) A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder. J Clin Psychiatry 64:1013-1024
22. Calabrese JR, Rapport DJ, Youngstrom EA, Jackson K, Bilali S, Findling RL (2005) New data on the use of lithium, divalproate, and lamotrigine in rapid cycling bipolar disorder. Eur Psychiatr 20:92-95
23. Chang MC, Grange E, Rabin O, Bell JM, Allen DD, Rapoport SI (1996) Lithium decreases turnover of arachidonate in several brain phospholipids. Neurosci Lett 220:171-174
24. Chang MC, Bell JM, Purdon AD, Chikhale EG, Grange E (1999) Dynamics of docosahexaenoic acid metabolism in the central nervous system: lack of effect of chronic lithium treatment. Neurochem Res 24:399-406
25. Chang MC, Contreras MA, Rosenberger TA, Rintala JJ, Bell JM, Rapoport SI (2001) Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brain phospholipids: a possible common effect of mood stabilizers. J Neurochem 77:796-803
26. Cunnane SC, Ryan MA, Nadeau CR, Bazinet RP, Musa-Veloso K, McCloy U (2003) Why is carbon from some polyunsaturates extensively recycled into lipid synthesis? Lipids 38:477-484
27. DeGeorge JJ, Noronha JG, Bell J, Robinson P, Rapoport SI (1989) Intravenous injection of [1-14C]arachidonate to examine regional brain lipid metabolism in unanesthetized rats. J Neurosci Res 24:413-23
28. DeMar JC, Jr., Lee HJ, Ma K, Chang L, Bell JM, Rapoport SI, Bazinet RP (2006a) Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. Biochim Biophys Acta 1761:1050-1059
29. DeMar JC, Jr., Ma K, Bell JM, Igarashi M, Greenstein D, Rapoport SI (2006b) One generation of n-3 polyunsaturated fatty acid deprivation increases depression and aggression test scores in rats. J Lipid Res 47:172-180
30. Deutsch J, Grange E, Rapoport SI, Purdon AD (1994) Isolation and quantitation of long-chain acyl-coenzyme A esters in brain tissue by solid-phase extraction. Anal Biochem 220:321-323
31. Deutsch J, Rapoport SI, Purdon AD (1997) Relation between free fatty acid and acyl-CoA concentrations in rat brain following decapitation. Neurochem Res 22:759-765
32. Doose DR, Brodie MJ, Wilson EA, Chadwick D, Oxbury J, Berry DJ, Schwabe S, Bialer M (2003) Topiramate and lamotrigine pharmacokinetics during repetitive monotherapy and combination therapy in epilepsy patients. Epilepsia 44:917-922
33. Fatemi SH, Rapport DJ, Calabrese JR, Thuras P (1997) Lamotrigine in rapid-cycling bipolar disorder. J Clin Psychiatry 58:522-527
34. Felder CC, Kanterman RY, Ma AL, Axelrod J (1990) Serotonin stimulates phospholipase A2 and the release of arachidonic acid in hippocampal neurons by a type 2 serotonin receptor that is independent of inositolphospholipid hydrolysis. Proc Natl Acad Sci USA 87:2187-2191
35. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226:497-509
36. Funk CD (2001) Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294:1871-1875
37. Ghelardoni S, Tomita YA, Bell JM, Rapoport SI, Bosetti F (2004) Chronic carbamazepine selectively downregulates cytosolic phospholipase A2 expression and cyclooxygenase activity in rat brain. Biol Psychiatry 56:248-254
38. Ghelardoni S, Bazinet RP, Rapoport SI, Bosetti F (2005) Topiramate does not alter expression in rat brain of enzymes of arachidonic acid metabolism. Psychopharmacology (Berl) 180:523-529
39. Grange E, Deutsch J, Smith QR, Chang M, Rapoport SI, Purdon AD (1995) Specific activity of brain palmitoyl-CoA pool provides rates of incorporation of palmitate in brain phospholipids in awake rats. J Neurochem 65:2290-2298
40. Grunze HC, Normann C, Langosch J, Schaefer M, Amann B, Sterr A, Schloesser S, Kleindienst N, Walden J (2001) Antimanic efficacy of topiramate in 11 patients in an open trial with an on-off-on design. J Clin Psychiatry 62:464-468
41. Hassel B, Tauboll E, Gjerstad L (2001) Chronic lamotrigine treatment increases rat hippocampal GABA shunt activity and elevates cerebral taurine levels. Epilepsy Res 43:153-163
42. Kushner SF, Khan A, Lane R, Olson WH (2006) Topiramate monotherapy in the management of acute mania: results of four double-blind placebo-controlled trials. Bipolar Disord 8:15-27
43. Lands WEM, Crawford CG (1976) Enzymes of membrane phospholipid metabolism. In: Martonosi A (ed) The enzymes of biological membranes. Biosynthesis of cell components, vol. 2. Plenum, New York, pp 3-85
44. Lee HJ, Ghelardoni S, Chang L, Bosetti F, Rapoport SI, Bazinet RP (2005) Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized rat. Neurochem Res 30:677-683
45. Lee HJ, Rao JS, Ertley RN, Chang L, Rapoport SI, Bazinet RP (2007) Chronic fluoxetine increases cytosolic phospholipase A(2) activity and arachidonic acid turnover in brain phospholipids of the unanesthetized rat. Psychopharmacology (Berl) 190:103-115
46. Leverich GS, Altshuler LL, Frye MA, Suppes T, McElroy SL, Keck PE Jr, Kupka RW, Denicoff KD, Nolen WA, Grunze H, Martinez MI, Post RM (2006) Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers. Am J Psychiatry 163:232-239
47. Makrides M, Neumann MA, Byard RW, Simmer K, Gibson RA (1994) Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am J Clin Nutr 60:189-194
48. Malik S, Arif H, Hirsch LJ (2006) Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. Expert Rev Neurother 6:1609-1627
49. McElroy SL, Suppes T, Keck PE, Frye MA, Denicoff KD, Altshuler LL, Brown ES, Nolen WA, Kupka RW, Rochussen J, Leverich GS, Post RM (2000) Open-label adjunctive topiramate in the treatment of bipolar disorders. Biol Psychiatry 47:1025-1033
50. McGeer EG, Zhu SG (1990) Lamotrigine protects against kainate but not ibotenate lesions in rat striatum. Neurosci Lett 112:348-351
51. Muller N, Schwarz MJ, Dehning S, Douhe A, Cerovecki A, Goldstein-Muller B, Spellmann I, Hetzel G, Maino K, Kleindienst N, Moller HJ, Arolt V, Riedel M (2006) The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine. Mol Psychiatry 11:680-684
52. Muzina DJ, Elhaj O, Gajwani P, Gao K, Calabrese JR (2005) Lamotrigine and antiepileptic drugs as mood stabilizers in bipolar disorder. Acta Psychiatr Scand Suppl:21-28
53. O'Brien JS, Sampson EL (1965) Lipid composition of the normal human brain: gray matter, white matter, and myelin. J Lipid Res 6:537-544
54. Piomelli D, Pilon C, Giros B, Sokoloff P, Martres MP, Schwartz JC (1991) Dopamine activation of the arachidonic acid cascade as a basis for D1/D2 receptor synergism. Nature 353:164-167
55. Post RM, Leverich GS, Nolen WA, Kupka RW, Altshuler LL, Frye MA, Suppes T, McElroy S, Keck P, Grunze H, Walden J (2003) A re-evaluation of the role of antidepressants in the treatment of bipolar depression: data from the Stanley Foundation Bipolar Network. Bipolar Disord 5:396-406
56. Rao JS, Rapoport SI, Bosetti F (2005) Decrease in the AP-2 DNA-binding activity and in the protein expression of AP-2 alpha and AP-2 beta in frontal cortex of rats treated with lithium for 6 weeks. Neuropsychopharmacology 30:2006-2013
57. Rao JS, Bazinet RP, Rapoport SI, Lee HJ (2007) Chronic treatment of rats with sodium valproate downregulates frontal cortex NF-kB DNA binding activity and COX-2 mRNA. Bipolar Disord (in press)
58. Rao JS, Ertley RN, Lee HJ, Rapoport SI, Bazinet RP (2006) Chronic fluoxetine upregulates activity, protein and mRNA levels of cytosolic phospholipase A2 in rat frontal cortex. Pharmacogenomics J 6:413-420
59. Rao JS, Bazinet RP, Rapoport SI, Lee HJ (2007a) Chronic administration of carbamazepine down-regulates AP-2 DNA-binding activity and AP-2alpha protein expression in rat frontal cortex. Biol Psychiatry 61:154-61
60. Rao JS, Ertley RN, DeMar JC, Jr., Rapoport SI, Bazinet RP, Lee HJ (2007b) Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol Psychiatry 12:151-157
61. Rapoport SI, Bosetti F (2002) Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder? Arch Gen Psychiatry 59:592-596
62. Rapoport SI, Chang MC, Spector AA (2001) Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. J Lipid Res 42:678-685
63. Rintala J, Seemann R, Chandrasekaran K, Rosenberger TA, Chang L, Contreras MA, Rapoport SI, Chang MC (1999) 85 kDa cytosolic phospholipase A2 is a target for chronic lithium in rat brain. Neuroreport 10:3887-3890
64. Robinson PJ, Noronha J, DeGeorge JJ, Freed LM, Nariai T, Rapoport SI (1992) A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res Brain Res Rev 17:187-214
65. Serhan CN, Oliw E (2001) Unorthodox routes to prostanoid formation: new twists in cyclooxygenase-initiated pathways. J Clin Invest 107:1481-1489
66. Shimizu T, Wolfe LS (1990) Arachidonic acid cascade and signal transduction. J Neurochem 55:1-15
67. Skipski VP, Good JJ, Barclay M, Reggio RB (1968) Quantitative analysis of simple lipid classes by thin-layer chromatography. Biochim Biophys Acta 152:10-19
68. Washizaki K, Smith QR, Rapoport SI, Purdon AD (1994) Brain arachidonic acid incorporation and precursor pool specific activity during intravenous infusion of unesterified [3H]arachidonate in the anesthetized rat. J Neurochem 63:727-736
69. Weisler RH, Kalali AH, Ketter TA (2004) A multicenter, randomized, double-blind, placebo-controlled trial of extended-release carbamazepine capsules as monotherapy for bipolar disorder patients with manic or mixed episodes. J Clin Psychiatry 65:478-484
70. Weisler RH, Cutler AJ, Ballenger JC, Post RM, Ketter TA (2006) The use of antiepileptic drugs in bipolar disorders: a review based on evidence from controlled trials. CNS Spectr 11:788-799
71. Yatham LN, Kennedy SH, O'Donovan C, Parikh SV, Macqueen G, McIntyre RS, Sharma V, Beaulieu S (2006) Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: update 2007. Bipolar Disord 8:721-739