Roles of D-serine in the mammalian brain

Brain and Nerve

Volumn 59, Issue 7, 2007, Pages 725-730

  Zhao, Ying Luan ^a   Mori, Hisashi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Astrocyte; D serine; Gliotransmitter; NMDA receptor; Serine racemase

Indexed keywords

DEXTRO SERINE; GLUTAMATE RECEPTOR; GLYCINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; RACEMASE; SERINE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ISOMERASE; SERINE RACEMASE; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTE; BRAIN DEATH; BRAIN NERVE CELL; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM; ENCEPHALITIS; EXCITOTOXICITY; NERVE CELL PLASTICITY; NEUROPATHIC PAIN; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SCHIZOPHRENIA; SYNAPTIC TRANSMISSION; SYNAPTOGENESIS; ANIMAL; BIOSYNTHESIS; BRAIN; CELL DEATH; METABOLISM; MOUSE; PAIN; PHYSIOLOGY; REVIEW; SYNAPSE;

ANIMALS; ASTROCYTES; BRAIN; CELL DEATH; MICE; NEURONAL PLASTICITY; NEUROTRANSMITTER AGENTS; PAIN; RACEMASES AND EPIMERASES; RECEPTORS, N-METHYL-D-ASPARTATE; SCHIZOPHRENIA; SERINE; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 34447629907     PISSN: 00068969     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Wolosker H, Blackshaw S, Snyder SH: Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A 96: 13409-13414, 1999
2. Iwama H, Takahashi K, Kure S, Hayashi F, Narisawa K, et al: Depletion of cerebral D-serine in non-ketotic hyperglycinemia: possible involvement of glycine cleavage system in control of endogenous D-serine. Biochem Biophys Res Commun 231: 793-796, 1997
3. Wang LZ, Zhu XZ: Spatiotemporal relationships among D-serine, serine racemase, and D-amino acid oxidase during mouse postnatal development. Acta Pharmacol Sin 24: 965-974, 2003
4. Schell MJ, Brady RO Jr, Molliver ME, Snyder SH: D-Serine as a neuromodulator: Regional and developmental localizations in rat brain glia resemble NMDA receptors. J Neurosci 17: 1604-1615, 1997
5. Kartvelishvily E, Shleper M, Balan L, Dumin E, Wolosker H: Neuron-derived D-serine release provides a novel means to activate N-Methyl-D-aspartate Receptors. J Biol Chem 281: 14151-14162, 2006
6. Hashimoto A, Oka T: Free D-aspartate and D-serine in the mammalian brain and periphery. Prog Neurobiol 52: 325-353, 1997
7. Williams SM, Diaz CM, Macnab LT, Sullivan RK, Pow DV: Immunocytochemical analysis of D-serine distribution in the mammalian brain reveals novel anatomical compartmentalizations in glia and neurons. Glia 53: 401-411, 2006
8. Kim PM, Aizawa H, Kim PS, Huang AS, Wickramasinghe SR, et al: Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration. Proc Natl Acad Sci U S A 102: 2105-2110, 2005
9. Mothet JP, Pollegioni L, Ouanounou G, Martineau M, Fossier P, et al: Glutamate receptor activation triggers a calcium-dependent and SNARE protein-dependent release of the gliotransmitter D-serine. Proc Natl Acad Sci U S A 102: 5606-5611, 2005
10. Matsuo H, Kanai Y, Tokunaga M, Nakata T, Chairoungdua A, et al: High affinity D- and L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices. Neurosci Lett 358: 123-126, 2004
11. Nakauchi J, Matsuo H, Kim DK, Goto A, Chairoungdua A, et al: Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity. Neurosci Lett 287: 23-235, 2000
12. Moreno S, Nardacci R, Cimini A, Ceru MP: Immunocytochemical localization of D-amino acid oxidase in rat brain. J Neurocytol 28: 169-185, 1999
13. Hamase K, Konno R, Morikawa A, Zaitsu K: Sensitive determination of D-amino acids in mammals and the effect of D-amino-acid oxidase activity on their amounts. Biol Pharm Bull 28: 1578-1584, 2005
14. Foltyn VN, Bendikov I, De Miranda J, Panizzutti R, Dumin E, et al: Serine racemase modulates intracellular D-serine levels through an alpha, beta-elimination activity. J Biol Chem 280: 1754-1763, 2005
15. Matsui T, Sekiguchi M, Hashimoto A, Tomita U, Nishikawa T, et al: Functional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J Neurochem 65: 454-8, 1995
16. Yang Y, Ge W, Chen Y, Zhang Z, Shen W, et al: Contribution of astrocytes to hippocampal long-term potentiation through release of D-serine. Proc Natl Acad Sci U S A 100: 15194-15199, 2003
17. Panatier A, Theodosis DT, Mothet JP, Touquet B, Pollegioni L, et al: Glia-derived D-serine controls NMDA receptor activity and synaptic memory. Cell 125: 775-784, 2006
18. Javitt DC: Glutamate as a therapeutic target in psychiatric disorders. Mol Psychiatry 9: 984-997, 2004
19. Mechri A, Saoud M, Khiari G, d'Amato T, Dalery J, et al: Glutaminergic hypothesis of schizophrenia: clinical research studies with ketamine. Encephale 27: 53-59, 2001
20. Hashimoto K, Fukushima T, Shimizu E, Komatsu N, Watanabe H, et al: Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Arch Gen Psychiatry 60: 572-576, 2003
21. Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, et al: Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A 99: 13675-13680, 2002
22. Katsuki H, Nonaka M, Shirakawa H, Kume T, Akaike A: Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices. J Pharmacol Exp Ther 311: 836-844, 2004
23. Shleper M, Kartvelishvily E, Wolosker H: D-serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices. J Neurosci 25:9413-9417, 2005
24. Wu S, Barger SW: Induction of serine racemase by inflammatory stimuli is dependent on AP-1. Ann N Y Acad Sci 1035: 133-146, 2004
25. Wu SZ, Bodles AM, Porter MM, Griffin WS, Basile AS, et al: Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide. J Neuroinflammation 1: 1-11, 2004
26. Wake K, Yamazaki H, Hanzawa S, Konno R, Sakio H, et al: Exaggerated responses to chronic nociceptive stimuli and enhancement of N-methyl-D-aspartate receptor-mediated synaptic transmission in mutant mice lacking D-amino-acid oxidase. Neurosci Lett 297: 25-28, 2001
27. Guo JD, Wang H, Zhang YQ, Zhao ZQ: Alterations of membrane properties and effects of D-serine on NMDA-induced current in rat anterior cingulate cortex neurons after monoarthritis Neurosci Lett 384: 245-249, 2005