Rodent Leydig cell tumorigenesis: A review of the physiology, pathology, mechanisms, and relevance to humans

Critical Reviews in Toxicology

Volumn 29, Issue 2, 1999, Pages 169-261

  Cook, Jon C ^a,f   Klinefelter, Gary R ^b   Hardisty, Jerry F ^c   Sharpe, Richard M ^d   Foster, Paul M D ^e  

^a DUPONT COMPANY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^f PFIZER INC   (United States)

Author keywords

Chemically induced Leydig cell tumors; Human relevance of rodent Leydig cell tumors; Interstitial cell; Interstitial cell tumors; Leydig cell; Leydig cell tumors; Review; Testis

Indexed keywords

1,3 BUTADIENE; ACTIVIN; ALCOHOL; ANTIESTROGEN; ANTIHYPERTENSIVE AGENT; ANTITHYROID AGENT; AROMATASE INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR; CADMIUM; CALCIUM CHANNEL BLOCKING AGENT; DIBROMOCHLOROPROPANE; DOPAMINE RECEPTOR STIMULATING AGENT; FUNGICIDE; GONADORELIN AGONIST; GROWTH FACTOR; HORMONE RECEPTOR BLOCKING AGENT; INHIBIN; INTERLEUKIN 1; LACTOSE; LEAD ACETATE; NICOTINE; ORGANOCHLORINE DERIVATIVE; PEROXISOME PROLIFERATOR; SOMATOMEDIN C; STEROID 5ALPHA REDUCTASE INHIBITOR; SUGAR; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA; TRICHLOROETHYLENE; UNINDEXED DRUG;

ADENOMA; CANCER INCIDENCE; CARCINOGENESIS; CELL COUNT; CELL HYPERPLASIA; CELL PROLIFERATION; CYTOLOGY; GENOTOXICITY; HISTOPATHOLOGY; HORMONAL REGULATION; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; LEYDIG CELL TUMOR; NONHUMAN; ONTOGENY; PARACRINE SIGNALING; RAT; REGULATORY MECHANISM; REVIEW; SPERMATOGENESIS; TESTOSTERONE SYNTHESIS;

ANIMALIA; RODENTIA;

EID: 0032903895     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.1080/10408449991349203     Document Type: Review

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