Gene transfer of human TCR in primary murine T cells is improved by pseudo-typing with amphotropic and ecotropic envelopes

Journal of Gene Medicine

Volumn 9, Issue 7, 2007, Pages 561-570

  Pouw, Nadine M C ^a   Westerlaken, Elike J ^a   Willemsen, Ralph A ^a   Debets, Reno ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

GFP; Primary murine T lymphocyte; Retroviral transduction; TCR; Viral envelope

Indexed keywords

GAG PROTEIN; GLYCOPROTEIN GP 100; GREEN FLUORESCENT PROTEIN; INTERLEUKIN 2; POL PROTEIN; RETROVIRUS VECTOR; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL DENSITY; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DNA PACKAGING; ENVELOPE GENE; GENE EXPRESSION; GENETIC TRANSDUCTION; GENETIC TRANSFECTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PSEUDOTYPING; T LYMPHOCYTE ACTIVATION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD28; ANTIGENS, CD3; CELL COUNT; CELL PROLIFERATION; CONCANAVALIN A; HUMANS; LYMPHOCYTE ACTIVATION; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, VIRUS; RETROVIRIDAE; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE III; SOLUBILITY; T-LYMPHOCYTES; TRANSDUCTION, GENETIC; VIRUS ASSEMBLY;

GIBBON APE LEUKEMIA VIRUS; MURINAE; MURINE LEUKEMIA VIRUS; VESICULAR STOMATITIS VIRUS;

EID: 34447569374     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1047     Document Type: Article

References (29)

1. Rosenberg SA, et al. Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2. J Natl Cancer Inst 1994; 86: 1159-1166.
2. Walter EA, et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 1995; 333: 1038-1044.
3. Dudley ME, et al. A phase I study of nonmyeloablative chemotherapy and adoptive transfer of autologous tumor antigen-specific T lymphocytes in patients with metastatic melanoma. J Immunothe. 2002; 25: 243-251.
4. Yee C, et al. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc Natl Acad Sci U S A 2002; 99: 16168-16173.
5. Rosenberg SA, Dudley ME. Cancer regression in patients with metastatic melanoma after the transfer of autologous antitumor lymphocytes. Proc Natl Acad Sci USA 2004; 101(Suppl 2): 14639-14645.
6. Dudley ME, et al. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol 2005; 23: 2346-2357.
7. Clay TM, Custer MC, Sachs J, Hwu P, Rosenberg SA, Nishimura MI. Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity. J Immunol 1999; 163: 507-513.
8. Willemsen RA, et al. Grafting primary human T lymphocytes with cancer-specific chimeric single chain and two chain TCR. Gene Ther 2000; 7: 1369-1377.
9. Schaft N, et al. Peptide fine specificity of anti-glycoprotein 100 CTL is preserved following transfer of engineered TCR alpha beta genes into primary human T lymphocytes. J Immunol 2003; 170: 2186-2194.
10. Lamers C, Willemsen R, van Elzakker P, van Krimpen B, Gratama J, Debets R. Phoenix-ampho outperforms PG13 as retroviral packaging cells to transduce human T cells with tumor-specific receptors: implications for clinical immunogene therapy of cancer. Cancer Gene Ther 2006; 13: 503-509.
11. Lamers CHJ, et al. Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience. J Clin Oncol 2006; 24: e20-22.
12. Kershaw MH, et al. A phase I study utilizing adoptive transfer of gene-modified T cells for ovarian cancer. Clin Cancer Res 2006; submitted.
13. Morgan RA, et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 2006; in press.
14. Hagani AB, Rivière I, Tan C, Krause A, Sadelain M. Activation conditions determine susceptibility of murine primary T-lymphocytes to retroviral infection. J Gene Med 1999; 1: 341-351.
15. Haynes NM, et al. Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation. J Immunol 2002; 169: 5780-5786.
16. Kessels HW, Wolkers MC, van den Boom MD, van der Valk MA, Schumacher TN. Immunotherapy through TCR gene transfer. Nat Immunol 2001; 2: 957-961.
17. Beisner DR, Chu IH, Arechiga AF, Hedrick SM, Walsh CM. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. J Immunol 2003; 171: 247-256.
18. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003; 299: 1057-1061.
19. Rubinstein MP, et al. Transfer of TCR genes into mature T cells is accompanied by the maintenance of parental T cell avidity. J Immunol 2003; 170: 1209-1217.
20. Zhang T, Tsang TC, Harris DT. Efficient transduction of murine primary T cells requires a combination of high viral titer, preferred tropism, and proper timing of transduction. J Hematother Stem Cell Res 2003; 12: 123.
21. Chamoto K, et al. Potentiation of tumor eradication by adoptive immunotherapy with T-cell receptor gene-transduced T-helper type 1 cells. Cancer Res 2004; 64: 386-390.
22. Fujio K, et al. Nucleosome-specific regulatory T cells engineered by triple gene transfer suppress a systemic autoimmune disease. J Immunol 2004; 173: 2118-2125.
23. Weijtens MEM, Willemsen RA, Hart EH, Bolhuis RLH. A retroviral vector system 'STITCH' in combination with an optimized single chain antibody chimeric receptor gene structure allows efficient gene transduction and expression in human T lymphocytes. Gene Ther 1998; 5: 1195.
24. Stanislawski T, et al. Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer. Nat Immunol 2001; 2: 962-970.
25. Zarour H, et al. The majority of autologous cytolytic T-lymphocyte clones derived from peripheral blood lymphocytes of a melanoma patient recognize an antigenic peptide derived from gene Pmel17/gp100. J Invest Dermatol 1996; 107: 63-67.
26. Eshhar Z, Waks T, Bendavid A, Schindler DG. Functional expression of chimeric receptor genes in human T cells. J Immunol Methods 2001; 248: 67-76.
27. Lamers CH, Willemsen RA, Luider BA, Debets R, Bolhuis RL. Protocol for gene transduction and expansion of human T lymphocytes for clinical immunogene therapy of cancer. Cancer Gene Ther 2002; 9: 613-623.
28. Zhang T, He X, Tsang TC, Harris DT. Transgenic TCR expression: comparison of single chain with full-length receptor constructs for T-cell function. Cancer Gene Ther 2004; 11: 487-496.
29. Madsen LS, et al. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat Genet 1999; 23: 343-347.