Heterologous expression of the adenosine A1 receptor in transgenic mouse retina

Biochemistry

Volumn 46, Issue 28, 2007, Pages 8350-8359

  Li, Ning ^a,d   Salom, David ^a,d   Zhang, Li ^a,e   Harris, Tim ^a,f   Ballesteros, Juan A ^a,g   Golczak, Marcin ^b   Jastrzebska, Beata ^b   Palczewski, Krzysztof ^b   Kurahara, Carole ^c   Juan, Todd ^c   Jordan, Steven ^c   Salon, John A ^c  

^a Novasite Pharmaceuticals Inc   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c AMGEN INC   (United States)

^d Polgenix Inc   (United States)

^e Forbes Medi Tech Inc   (United States)

^f SAIC FREDERICK INC   (United States)

^g OrphaMed SL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MOUSE OPSIN PROMOTER; PHOTORECEPTOR SYSTEMS; RHODOPSIN ROD;

CELLS; CONFORMATIONS; PROTEINS;

BIOCHEMISTRY;

ADENOSINE A1 RECEPTOR; G PROTEIN COUPLED RECEPTOR; MEMBRANE RECEPTOR; RECEPTOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GLYCOSYLATION; IN VIVO STUDY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; QUALITY CONTROL; RETINA; SOLUBILIZATION; TRANSGENIC MOUSE;

ANIMALS; CELL LINE; GENETIC ENGINEERING; HUMANS; LIGANDS; MICE; MICE, TRANSGENIC; PHOTORECEPTORS, VERTEBRATE; RECEPTOR, ADENOSINE A1; RETINA;

MUS MUSCULUS;

EID: 34447565075     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700154h     Document Type: Article

References (42)

1. Lefkowitz, R. J. (2004) Historical review: A brief history and personal retrospective of seven-transmembrane receptors, Trends Pharmacol. Sci. 25, 413-422.
2. Thompson, M. D., Burnham, W. M., and Cole, D. E. (2005) The G protein-coupled receptors: pharmacogenetics and disease, Crit. Rev. Clin. Lab. Sci. 42, 311-392.
3. Schlyer, S., and Horuk, R. (2006) I want a new drug: G-protein-coupled receptors in drug development, Drug Discov. Today 11, 481-493.
4. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le Trong, I., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Crystal structure of rhodopsin: A G protein-coupled receptor, Science 289, 739-745.
5. Salom, D., Lodowski, D. T., Stenkamp, R. E., Le Trong, I., Golczak, M., Jastrzebska, B., Harris, T., Ballesteros, J. A., and Palczewski, K. (2006) Crystal structure of a photoactivated deprotonated intermediate of rhodopsin, Proc. Natl. Acad. Sci. U.S.A. 103, 16123-16128.
6. Ridge, K. D., and Palczewski, K. (2007) Visual rhodopsin sees the light: structure and mechanism of G protein signaling, J. Biol. Chem. 282, 9297-9301.
7. Palczewski, K. (2006) G protein-coupled receptor rhodopsin, Annu. Rev. Biochem. 75, 743-767.
8. Okada, T., Le Trong, I., Fox, B. A., Behnke, C. A., Stenkamp, R. E., and Palczewski, K. (2000) X-Ray diffraction analysis of three-dimensional crystals of bovine rhodopsin obtained from mixed micelles, J. Struct. Biol. 130, 73-80.
9. Deretic, D. (2006) A role for rhodopsin in a signal transduction cascade that regulates membrane trafficking and photoreceptor polarity, Vision Res. 46, 4427-4433.
10. Filipek, S., Stenkamp, R. E., Teller, D. C., and Palczewski, K. (2003) G protein-coupled receptor rhodopsin: A prospectus, Annu. Rev. Physiol. 65, 851-879.
11. Eroglu, C., Cronet, P., Panneels, V., Beaufils, P., and Sinning, I. (2002) Functional reconstitution of purified metabotropic glutamate receptor expressed in the fly eye, EMBO Rep. 3, 491-496.
12. Eroglu, C., Brugger, B., Wieland, F., and Sinning, I. (2003) Glutamate-binding affinity of Drosophila metabotropic glutamate receptor is modulated by association with lipid rafts, Proc. Natl. Acad. Sci. U.S.A. 100, 10219-10224.
13. Zhang, L., Salom, D., He, J., Okun, A., Ballesteros, J., Palczewski, K., and Li, N. (2005) Expression of functional G protein-coupled receptors in photoreceptors of transgenic Xenopus laevis, Biochemistry 44, 14509-14518.
14. al-Ubaidi, M. R., Pittler, S. J., Champagne, M. S., Triantafyllos, J. T., McGinnis, J. F., and Baehr, W. (1990) Mouse opsin. Gene structure and molecular basis of multiple transcripts, J. Biol Chem. 265, 20563-20569.
15. Zack, D. J., Bennett, J., Wang, Y., Davenport, C., Klaunberg, B., Gearhart, J., and Nathans, J. (1991) Unusual topography of bovine rhodopsin promoter-lacZ fusion gene expression in transgenic mouse retinas, Neuron 6, 187-199.
16. Lem, J., Applebury, M. L., Falk, J. D., Flannery, J. G., and Simon, M. I. (1991) Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice, Neuron 6, 201-210.
17. Kashanchi, F., Thompson, J., Sadaie, M. R., Doniger, J., Duvall, J., Brady, J. N., and Rosenthal, L. J. (1994) Transcriptional activation of minimal HIV-1 promoter by ORF-1 protein expressed from the SalI-L fragment of human herpesvirus 6, Virology 201, 95-106.
18. MacKenzie, D., Arendt, A., Hargrave, P., McDowell, J. H., and Molday, R. S. (1984) Localization of binding sites for carboxyl terminal specific anti-rhodopsin monoclonal antibodies using synthetic peptides, Biochemistry 23, 6544-6549.
19. Brinster, R. L., Chen, H. Y., Trumbauer, M. E., Yagle, M. K., and Palmiter, R. D. (1985) Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs, Proc. Natl. Acad. Sci. U.S.A. 82, 4438-4442.
20. Simonet, W. S., Hughes, T. M., Nguyen, H. Q., Trebasky, L. D., Danilenko, D. M., and Medlock, E. S. (1994) Long-term impaired neutrophil migration in mice overexpressing human interleukin-8, J. Clin. Invest. 94, 1310-1319.
21. Jewell-Motz, E. A., Donnelly, E. T., Eason, M. G., and Liggett, S. B. (1998) Agonist-mediated downregulation of G alpha i via the alpha 2-adrenergic receptor is targeted by receptor-Gi interaction and is independent of receptor signaling and regulation, Biochemistry 37, 15720-15725.
22. Zhang, X., Wensel, T. G., and Kraft, T. W. (2003) GTPase regulators and photoresponses in cones of the eastern chipmunk, J. Neurosci. 23, 1287-1297.
23. Adamus, G., Zam, Z. S., Arendt, A., Palczewski, K., McDowell, J. H., and Hargrave, P. A. (1991) Anti-rhodopsin monoclonal antibodies of defined specificity: characterization and application, Vision Res. 31, 17-31.
24. Ye, H., Holterman, A. X., Yoo, K. W., Franks, R. R., and Costa, R. H. (1999) Premature expression of the winged helix transcription factor HFH-11B in regenerating mouse liver accelerates hepatocyte entry into S phase, Mol. Cell. Biol. 19, 8570-8580.
25. Zhu, L., Jang, G. F., Jastrzebska, B., Filipek, S., Pearce-Kelling, S. E., Aguirre, G. D., Stenkamp, R. E., Acland, G. M., and Palczewski, K. (2004) A naturally occurring mutation of the opsin gene (T4R) in dogs affects glycosylation and stability of the G protein-coupled receptor, J. Biol. Chem. 279, 53828-53839.
26. Zhu, L., Imanishi, Y., Filipek, S., Alekseev, A., Jastrzebska, B., Sun, W., Saperstein, D. A., and Palczewski, K. (2006) Autosomal recessive retinitis pigmentosa and E150K mutation in the opsin gene, J. Biol. Chem. 281, 22289-22298.
27. Breathnach, R., and Harris, B. A. (1983) Plasmids for the cloning and expression of full-length double-stranded cDNAs under control of the SV40 early or late gene promoter, Nucleic Acids Res. 11, 7119-7136.
28. Crouch, R., Purvin, V., Nakanishi, K., and Ebrey, T. (1975) lsorhodopsin II: artificial photosensitive pigment formed from 9,13-dicis retinal, Proc. Natl. Acad. Sci. U.S.A. 72, 1538-1542.
29. Jastrzebska, B., Fotiadis, D., Jang, G. F., Stenkamp, R. E., Engel, A., and Palczewski, K. (2006) Functional and structural characterization of rhodopsin oligomers, J. Biol. Chem. 281, 11917-11922.
30. Rivkees, S. A., Lasbury, M. E., and Barbhaiya, H. (1995) Identification of domains of the human A1 adenosine receptor that are important for binding receptor subtype-selective ligands using chimeric A1/A2a adenosine receptors, J. Biol. Chem. 270, 20485-20490.
31. Cordeaux, Y., Ijzerman, A. P., and Hill, S. J. (2004) Coupling of the human A1 adenosine receptor to different heterotrimeric G proteins: evidence for agonist-specific G protein activation, Br. J. Pharmacol. 143, 705-714.
32. Fredholm, B. B., Ap, I. J., Jacobson, K. A., Klotz, K. N., and Linden, J. (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors, Pharmacol. Rev. 53, 527-552.
33. Reeves, P. J., Callewaert, N., Contreras, R., and Khorana, H. G. (2002) Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line, Proc. Natl. Acad. Sci. U.S.A. 99, 13419-13424.
34. Chelikani, P., Reeves, P. J., Rajbhandary, U. L., and Khorana, H. G. (2006) The synthesis and high-level expression of a beta2-adrenergic receptor gene in a tetracycline-inducible stable mammalian cell line, Protein Sci. 15, 1433-1440.
35. Lundstrom, K., Wagner, R., Reinhart, C., Desmyter, A., Cherouati, N., Magnin, T., Zeder-Lutz, G., Courtot, M., Prual, C., Andre, N., Hassaine, G., Michel, H., Cambillau, C., and Pattus, F. (2006) Structural genomics on membrane proteins: comparison of more than 100 GPCRs in 3 expression systems, J. Struct. Funct. Genomics 7, 77-91.
36. Kodama, T., Imai, H., Doi, T., Chisaka, O., Shichida, Y., and Fujiyoshi, Y. (2005) Expression and localization of an exogenous G protein-coupled receptor fused with the rhodopsin C-terminal sequence in the retinal rod cells of knockin mice, Exp. Eye Res. 80, 859-869.
37. Fliesler, S. J., Rapp, L. M., and Hollyfield, J. G. (1984) Photoreceptor-specific degeneration caused by tunicamycin, Nature 311, 575-577.
38. Fliesler, S. J., Rayborn, M. E., and Hollyfield, J. G. (1985) Membrane morphogenesis in retinal rod outer segments: inhibition by tunicamycin, J. Cell Biol. 100, 574-587.
39. Salom, D., Le Trong, I., Pohl, E., Ballesteros, J. A., Stenkamp, R. E., Palczewski, K., and Lodowski, D. T. (2006) Improvements in G protein-coupled receptor purification yield light stable rhodopsin crystals, J. Struct. Biol. 156, 497-504.
40. Humphries, M. M., Rancourt, D., Farrar, G. J., Kenna, P., Hazel, M., Bush, R. A., Sieving, P. A., Sheils, D. M., McNally, N., Creighton, P., Erven, A., Boros, A., Gulya, K., Capecchi, M. R., and Humphries, P. (1997) Retinopathy induced in mice by targeted disruption of the rhodopsin gene, Nat. Genet. 15, 216-219.
41. Liang, Y., Fotiadis, D., Maeda, T., Maeda, A., Modzelewska, A., Filipek, S., Saperstein, D. A., Engel, A., and Palczewski, K. (2004) Rhodopsin signaling and organization in heterozygote rhodopsin knockout mice, J. Biol Chem. 279, 48189-48196.
42. Olsson, J. E., Gordon, J. W., Pawlyk, B. S., Roof, D., Hayes, A., Molday, R. S., Mukai, S., Cowley, G. S., Berson, E. L., and Dryja, T. P. (1992) Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa, Neuron 9, 815-830.