Flux profile and modularity analysis of time-dependent metabolic changes of de novo adipocyte formation

American Journal of Physiology - Endocrinology and Metabolism

Volumn 292, Issue 6, 2007, Pages

  Si, Yaguang ^a   Yoon, Jeongah ^b   Lee, Kyongbum ^b  

^a TUFTS UNIVERSITY   (United States)

^b Tufts University   (United States)

Author keywords

Adipocyte metabolism; Metabolic profile; Network modularity

Indexed keywords

COLLAGEN GEL; COLLAGEN TYPE 1; MALIC ACID; PENTOSE PHOSPHATE; TRACER;

ADIPOCYTE; ANALYTIC METHOD; ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CELL METABOLISM; CONTROLLED STUDY; EMBRYO; GENE EXPRESSION PROFILING; LIPID STORAGE; LIPOGENESIS; METABOLIC REGULATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; PROADIPOCYTE; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES, WHITE; ALGORITHMS; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; COLLAGEN TYPE I; DNA; GELS; LIPID METABOLISM; LIPOGENESIS; MALATES; MICE; PENTOSE PHOSPHATE PATHWAY; PHENOTYPE;

EID: 34447562749     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00670.2006     Document Type: Article

References (52)

1. Boone C, Mourot J, Gregoire F, Remacle C. The adipose conversion process: regulation by extracellular and intracellular factors. Reprod Nutr Dev 40: 325-358, 2000.
2. Bottcher H, Furst P. Decreased white fat cell thermogenesis in obese individuals. Int J Obes Relat Metab Disord 21: 439-444, 1997.
3. Boudreau NJ, Jones PL. Extracellular matrix and integrin signalling: the shape of things to come. Biochem J 339: 481-488, 1999.
4. Bray GA, Greenway FL. Current and potential drugs for treatment of obesity. Endocr Rev 20: 805-875, 1999.
5. Buttgereit F, Brand MD. A hierarchy of ATP-consuming processes in mammalian cells. Biochem J 312: 163-167, 1995.
6. Cabezas H, Raposo RR, Melendez-Hevia E. Activity and metabolic roles of the pentose phosphate cycle in several rat tissues. Mol Cell Biochem 201: 57-63, 1999.
7. Carmen GY, Victor SM. Signalling mechanisms regulating lipolysis. Cell Signal 18: 401-408, 2006.
8. Cohen SA, De Antonis KM. Applications of amino acid derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate. Analysis of feed grains, intravenous solutions and glycoproteins. J Chromatogr A 661: 25-34, 1994.
9. Cormen TH, Leiserson CE, Rivest RL, Stein C. Introduction to Algorithms. Cambridge, MA: The MIT Press, 2001.
10. Dani C, Doglio A, Grimaldi P, Ailhaud G. Expression of the phosphoenolpyruvate carboxykinase gene and its insulin regulation during differentiation of preadipose cell lines. Biochem Biophys Res Commun 138: 468-475, 1986.
11. Faust IM, Johnson PR, Stern JS, Hirsch J. Diet-induced adipocyte number increase in adult rats: a new model of obesity. Am J Physiol Endocrinol Metab Gastrointest Physiol 235: E279-E286, 1978.
12. Fell DA, Small JR. Fat synthesis in adipose tissue. An examination of stoichiometric constraints. Biochem J 238: 781-786, 1986.
13. Flatt JP. Conversion of carbohydrate to fat in adipose tissue: an energy-yielding and, therefore, self-limiting process. J Lipid Res 11: 131-143, 1970.
14. Flatt JP, Ball EG. Studies on the metabolism of adipose tissue. Xv. An evaluation of the major pathways of glucose catabolism as influenced by insulin and epinephrine. J Biol Chem 239: 675-685, 1964.
15. Goodridge AG, Fisch JE, Glynias MJ. Regulation of the activity and synthesis of malic enzyme in 3T3-L1 cells. Arch Biochem Biophys 228: 54-63, 1984.
16. Hauner H, Skurk T, Wabitsch M. Cultures of human adipose precursor cells. In: Adipose Tissue Protocols, edited by Ailhaud G. Totowa, NJ: Humana, 2001, p. xiii, 334.
17. Herrera MG, Philipps GR, Renold AE. Stimulation of metabolic activity of adipose tissue from fasted rats by prolonged incubation in vitro. I. Requirement for glucose and insulin. Biochim Biophys Acta 106: 221-233, 1965.
18. Hu CW, Utter MF, Patel MS. Induction of pyruvate dehydrogenase in 3T3-L1 cells during differentiation. J Biol Chem 258: 2315-2320, 1983.
19. Johnson PR, Stern JS, Greenwood MR, Hirsch J. Adipose tissue hyperplasia and hyperinsulinemia on Zucker obese female rats: a developmental study. Metabolism 27: 1941-1954, 1978.
20. Johnson PR, Zucker LM, Cruce JA, Hirsch J. Cellularity of adipose depots in the genetically obese Zucker rat. J Lipid Res 12: 706-714, 1971.
21. Kanehisa M, Goto S, Hattori M, Aoki-Kinoshita KF, Itoh M, Kawashima S, Katayama T, Araki M, Hirakawa M. From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res 34: D354-D357, 2006.
22. Kather H, Rivera M, Brand K. Interrelationship and control of glucose metabolism and lipogenesis in isolated fat-cells. Control of pentose phosphate-cycle activity by cellular requirement for reduced nicotinamide adenine dinucleotide phosphate. Biochem J 128: 1097-1102, 1972.
23. Katz J, Landau BR, Bartsch GE. The pentose cycle, triose phosphate isomerization, and lipogenesis in rat adipose tissue. J Biol Chem 241: 727-740, 1966.
24. Katz J, Rognstad R. The metabolism of tritiated glucose by rat adipose tissue. J Biol Chem 241: 3600-3610, 1966.
25. Kim MS, Yoon CY, Jang PG, Park YJ, Shin CS, Park HS, Ryu JW, Pak YK, Park JY, Lee KU, Kim SY, Lee HK, Kim YB, Park KS. The mitogenic and antiapoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol Endocrinol 18: 2291-2301, 2004.
26. Koh HJ, Lee SM, Son BG, Lee SH, Ryoo ZY, Chang KT, Park JW, Park DC, Song BJ, Veech RL, Song H, Huh TL. Cytosolic NADP+-dependent isocitrate dehydrogenase plays a key role in lipid metabolism. J Biol Chem 279: 39968-39974, 2004.
27. Lehninger AL, Nelson DL, Cox MM. Principles of Biochemistry. New York: WH Freeman, 2005.
28. Loomis ME. An enzymatic fluorometric method for the determination of lactic acid in serum. J Lab Clin Med 57: 966-969, 1961.
29. Ma H, Zeng AP. Reconstruction of metabolic networks from genome data and analysis of their global structure for various organisms. Bioinformatics 19: 270-277, 2003.
30. Mackall JC, Student AK, Polakis SE, Lane MD. Induction of lipogenesis during differentiation in a "preadipocyte" cell line. J Biol Chem 251: 6462-6464, 1976.
31. Martin BR, Denton RM. The intracellular localization of enzymes in white-adipose-tissue fat-cells and permeability properties of fat-cell mitochondria. Transfer of acetyl units and reducing power between mitochondria and cytoplasm. Biochem J 117: 861-877, 1970.
32. Melnikova I, Wages D. Anti-obesity therapies. Nat Rev Drug Discov 5: 369-370, 2006.
33. Newman ME, Girvan M. Finding and evaluating community structure in networks. Phys Rev E Stat Nonlin Soft Matter Phys 69: 026113, 2004.
34. Nolan RP, Fenley AP, Lee K. Identification of distributed metabolic objectives in the hypermetabolic liver by flux and energy balance analysis. Metab Eng 8: 30-45, 2006.
35. Olsen C. An enzymatic fluorimetric micromethod for the determination of acetoacetate, -hydroxybutyrate, pyruvate and lactate. Clin Chim Acta 33: 293-300, 1971.
36. Rajala MW, Scherer PE. Minireview: The adipocyte-at the crossroads of energy homeostasis, inflammation, and atherosclerosis. Endocrinology 144: 3765-3773, 2003.
37. Schuster S, Hilgetag C, Woods JH, Fell DA. Reaction routes in biochemical reaction systems: algebraic properties, validated calculation procedure and example from nucleotide metabolism. J Math Biol 45: 153-181, 2002.
38. Song H, O'Connor KC, Papadopoulos KD, Jansen DA. Differentiation kinetics of in vitro 3T3-L1 preadipocyte cultures. Tissue Eng 8: 1071-1081, 2002.
39. Sottile V, Seuwen K. A high-capacity screen for adipogenic differentiation. Anal Biochem 293: 124-128, 2001.
40. Soukas A, Socci ND, Saatkamp BD, Novelli S, Friedman JM. Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem 276: 34167-34174, 2001.
41. Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 104: 531-543, 2001.
42. Stryer L. Biochemistry. New York: WH Freeman, 1995.
43. Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen. J Clin Pathol 22: 158-161, 1969.
44. Veech RL, Eggleston LV, Krebs HA. The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver. Biochem J 115: 609-619, 1969.
45. Viravaidya K, Shuler ML. The effect of various substrates on cell attachment and differentiation of 3T3-F442A preadipocytes. Biotechnol Bioeng 78: 454-458, 2002.
46. von Heimburg D, Hemmrich K, Zachariah S, Staiger H, Pallua N. Oxygen consumption in undifferentiated versus differentiated adipogenic mesenchymal precursor cells. Respir Physiol Neurobiol 146: 107-116, 2005.
47. Wang T, Zang Y, Ling W, Corkey BE, Guo W. Metabolic partitioning of endogenous fatty acid in adipocytes. Obesity Res 11: 880-887, 2003.
48. Wickelgren I. Obesity: how big a problem? Science 280: 1364-1367, 1998.
49. Yonemitsu N, Bittinger F, Gerheld T, Sugihara H, Mittermayer C, Kirkpatrick CJ. Influence of extracellular matrix on the lipogenesis of cultured white fat cells. Acta Histochem Cytochem 31: 9-15, 1998.
50. Yoon J, Blumer A, Lee K. An algorithm for modularity analysis of directed and weighted biological networks based on edge-betweenness centrality. Bioinformatics 22: 3106-3108, 2006.
51. Yoon J, Lee K. Metabolic flux profiling of reaction modules in liver drug transformation. Pac Symp Biocomput 12: 193-204, 2007.
52. Young JW, Shrago E, Lardy HA. Metabolic control of enzymes involved in lipogenesis and gluconeogenesis. Biochemistry 3: 1687-1692, 1964.