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Volumn 12, Issue 4, 2007, Pages 351-356

Conversion from calcineurin inhibitors to mTOR inhibitors

Author keywords

Calcineurin inhibitor; Chronic allograft nephropathy; Sirolimus

Indexed keywords

CALCINEURIN INHIBITOR; CYCLOSPORIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RAPAMYCIN; TACROLIMUS;

EID: 34447536218     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e32819f8ef4     Document Type: Review
Times cited : (2)

References (60)
  • 1
    • 0029833753 scopus 로고    scopus 로고
    • A study of the quality of life and cost-utility of renal transplantation
    • Laupacis A, Keown P, Pus N, et al. A study of the quality of life and cost-utility of renal transplantation. Kidney Int 1996; 50:235-242.
    • (1996) Kidney Int , vol.50 , pp. 235-242
    • Laupacis, A.1    Keown, P.2    Pus, N.3
  • 2
    • 0033518231 scopus 로고    scopus 로고
    • Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of first cadaveric transplants
    • Wolfe RA, Ashby VB, Milford EL, et al. Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of first cadaveric transplants. N Engl J Med 1999; 341:1725-1730.
    • (1999) N Engl J Med , vol.341 , pp. 1725-1730
    • Wolfe, R.A.1    Ashby, V.B.2    Milford, E.L.3
  • 3
    • 1942502227 scopus 로고    scopus 로고
    • Withdrawal of cyclosporine or tacrolimus after addition of mycophenolate mofetil in patients with chronic allograft nephropathy
    • Suwelack B, Gerhardt U, Hohage H. Withdrawal of cyclosporine or tacrolimus after addition of mycophenolate mofetil in patients with chronic allograft nephropathy. Am J Transplant 2004; 4:655-662.
    • (2004) Am J Transplant , vol.4 , pp. 655-662
    • Suwelack, B.1    Gerhardt, U.2    Hohage, H.3
  • 4
    • 4644277373 scopus 로고    scopus 로고
    • Late calcineurin inhibitor withdrawal as a strategy to prevent graft loss in patients with suboptimal kidney transplant function
    • Weir MR, Blahut S, Drachenburg C, et al. Late calcineurin inhibitor withdrawal as a strategy to prevent graft loss in patients with suboptimal kidney transplant function. Am J Nephrol 2004; 24:379-386.
    • (2004) Am J Nephrol , vol.24 , pp. 379-386
    • Weir, M.R.1    Blahut, S.2    Drachenburg, C.3
  • 5
    • 0035884710 scopus 로고    scopus 로고
    • Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure
    • Johnson RW, Kreis H, Oberbauer R, et al. Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure. Transplantation 2001; 72:777-786.
    • (2001) Transplantation , vol.72 , pp. 777-786
    • Johnson, R.W.1    Kreis, H.2    Oberbauer, R.3
  • 6
    • 0037115133 scopus 로고    scopus 로고
    • Sirolimus Renal Function Study Group: Improved renal function in sirolimus treated renal transplant patients after early cyclosporine elimination
    • Gonwa TA, Hricik DE, Brinker K, et al. Sirolimus Renal Function Study Group: improved renal function in sirolimus treated renal transplant patients after early cyclosporine elimination. Transplantation 2002; 74:1560-1567.
    • (2002) Transplantation , vol.74 , pp. 1560-1567
    • Gonwa, T.A.1    Hricik, D.E.2    Brinker, K.3
  • 7
    • 0345161813 scopus 로고    scopus 로고
    • Sirolimus (Rapamycin)-based therapy in human renal transplantation: Similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group
    • Groth CG, Backman L, Morales JM, et al. Sirolimus (Rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group. Transplantation 1999; 67:1036-1042.
    • (1999) Transplantation , vol.67 , pp. 1036-1042
    • Groth, C.G.1    Backman, L.2    Morales, J.M.3
  • 8
    • 18244427344 scopus 로고    scopus 로고
    • Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients
    • Kreis H, Cisterne JM, Land W, et al. Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipients. Transplantation 2000; 69:1252-1260.
    • (2000) Transplantation , vol.69 , pp. 1252-1260
    • Kreis, H.1    Cisterne, J.M.2    Land, W.3
  • 9
    • 0037184316 scopus 로고    scopus 로고
    • Kidney transplantation without calcineurin inhibitor drugs: A prospective, randomized trial of sirolimus versus cyclosporine
    • Flechner SM, Goldfarb D, Modlin C, et al. Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporine. Transplantation 2002; 74:1770-1776.
    • (2002) Transplantation , vol.74 , pp. 1770-1776
    • Flechner, S.M.1    Goldfarb, D.2    Modlin, C.3
  • 10
    • 7244220158 scopus 로고    scopus 로고
    • De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years
    • Flechner SM, Kurian SM, Solez K, et al. De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years. Am J Transplant 2004; 4:1776-1785.
    • (2004) Am J Transplant , vol.4 , pp. 1776-1785
    • Flechner, S.M.1    Kurian, S.M.2    Solez, K.3
  • 11
    • 33644889043 scopus 로고    scopus 로고
    • Complete avoidance of calcineurin inhibitors in renal transplantation: A randomized trial comparing sirolimus and tacrolimus
    • Larson TS, Dean PG, Stegall M, et al. Complete avoidance of calcineurin inhibitors in renal transplantation: a randomized trial comparing sirolimus and tacrolimus. Am J Transplant 2006; 6:514-522.
    • (2006) Am J Transplant , vol.6 , pp. 514-522
    • Larson, T.S.1    Dean, P.G.2    Stegall, M.3
  • 12
    • 33750605108 scopus 로고    scopus 로고
    • Conversion from cyclosporine microemulsion to tacrolimus in stable kidney transplant patients with hypercholesterolemia is related to an improvement in cardiovascular risk profile: A prospective study
    • Marcen R, Chahin J, Alarcon A, Bravo J. Conversion from cyclosporine microemulsion to tacrolimus in stable kidney transplant patients with hypercholesterolemia is related to an improvement in cardiovascular risk profile: a prospective study. Transplant Proc 2006; 38:2427-2430.
    • (2006) Transplant Proc , vol.38 , pp. 2427-2430
    • Marcen, R.1    Chahin, J.2    Alarcon, A.3    Bravo, J.4
  • 13
    • 33745685284 scopus 로고    scopus 로고
    • Paired kidney analysis of tacrolimus and cyclosporine microemulsion-based therapy in Chinese cadaveric renal transplant recipients
    • Cheung CY, Wong KM, Chan HW, et al. Paired kidney analysis of tacrolimus and cyclosporine microemulsion-based therapy in Chinese cadaveric renal transplant recipients. Transpl Int 2006; 19:657-666.
    • (2006) Transpl Int , vol.19 , pp. 657-666
    • Cheung, C.Y.1    Wong, K.M.2    Chan, H.W.3
  • 14
    • 20344393398 scopus 로고    scopus 로고
    • Do blood pressure and arterial wall properties change after conversion from cyclosporine to tacrolimus?
    • Gelens MA, Christiaans MH, van Hoof JP. Do blood pressure and arterial wall properties change after conversion from cyclosporine to tacrolimus? Transplant Proc 2005; 37:1900-1901.
    • (2005) Transplant Proc , vol.37 , pp. 1900-1901
    • Gelens, M.A.1    Christiaans, M.H.2    van Hoof, J.P.3
  • 15
  • 16
    • 0038075448 scopus 로고    scopus 로고
    • Incidence and cost of new onset diabetes mellitus among U.S. wait-listed and transplanted renal allograft recipients
    • Woodward RS, Schnitzler MA, Baty J, et al. Incidence and cost of new onset diabetes mellitus among U.S. wait-listed and transplanted renal allograft recipients. Am J Transplant 2003; 3:590-598.
    • (2003) Am J Transplant , vol.3 , pp. 590-598
    • Woodward, R.S.1    Schnitzler, M.A.2    Baty, J.3
  • 17
    • 0034671108 scopus 로고    scopus 로고
    • Impact of immunosuppressive therapy on hypertension
    • MacDonald AS. Impact of immunosuppressive therapy on hypertension. Transplantation 2000; 70 (11 Suppl):S70-S76.
    • (2000) Transplantation , vol.70 , Issue.11 SUPPL.
    • MacDonald, A.S.1
  • 18
    • 22244461170 scopus 로고    scopus 로고
    • Endothelin-1 plasma levels and hypertension in cyclosporine-treated renal transplant patients
    • Cauduro RL, Costa C, Lhulier F, et al. Endothelin-1 plasma levels and hypertension in cyclosporine-treated renal transplant patients. Clin Transplant 2005; 19:470-474.
    • (2005) Clin Transplant , vol.19 , pp. 470-474
    • Cauduro, R.L.1    Costa, C.2    Lhulier, F.3
  • 19
    • 2342636824 scopus 로고    scopus 로고
    • Hyperlipidemia in renal transplant recipients
    • Hricik DE. Hyperlipidemia in renal transplant recipients. Graft 2000; 3:11-19.
    • (2000) Graft , vol.3 , pp. 11-19
    • Hricik, D.E.1
  • 20
    • 0036139867 scopus 로고    scopus 로고
    • Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based immunosuppression
    • van Duijnhoven EM, Christiians MH, Boots JM, et al. Glucose metabolism in the first 3 years after renal transplantation in patients receiving tacrolimus versus cyclosporine-based immunosuppression. J Am Soc Nephrol 2002; 13:213-220.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 213-220
    • van Duijnhoven, E.M.1    Christiians, M.H.2    Boots, J.M.3
  • 22
    • 0028787493 scopus 로고
    • Regulation of transforming growth factor-β and its receptor by cyclosporine in human T lymphocytes
    • Ahuja SS, Shrivastav S, Danielpour D, et al. Regulation of transforming growth factor-β and its receptor by cyclosporine in human T lymphocytes. Transplantation 1995; 60:718-723.
    • (1995) Transplantation , vol.60 , pp. 718-723
    • Ahuja, S.S.1    Shrivastav, S.2    Danielpour, D.3
  • 23
    • 0029145672 scopus 로고
    • Cyclosporine stimulates expression of transforming growth factor-β in renal cells
    • Wolf G, Thaiss F, Stahl RAK. Cyclosporine stimulates expression of transforming growth factor-β in renal cells. Transplantation 1995; 60:237-241.
    • (1995) Transplantation , vol.60 , pp. 237-241
    • Wolf, G.1    Thaiss, F.2    Stahl, R.A.K.3
  • 24
    • 0347382381 scopus 로고    scopus 로고
    • Mycophenolate mofetil ameliorates arteriolopathy and decreases transforming growth factor-β1 in chronic cyclosporine nephrotoxicity
    • Shihab FS, Bennett WM, Hong Y, et al. Mycophenolate mofetil ameliorates arteriolopathy and decreases transforming growth factor-β1 in chronic cyclosporine nephrotoxicity. Am J Transplant 2003; 3:1550-1559.
    • (2003) Am J Transplant , vol.3 , pp. 1550-1559
    • Shihab, F.S.1    Bennett, W.M.2    Hong, Y.3
  • 25
    • 0032946290 scopus 로고    scopus 로고
    • Rethinking chronic allograft nephropathy: The concept of accelerated senescence
    • Halloran PF, Melk A, Bath C. Rethinking chronic allograft nephropathy: the concept of accelerated senescence. J Am Soc Nephrol 1999; 10:167-173.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 167-173
    • Halloran, P.F.1    Melk, A.2    Bath, C.3
  • 26
    • 0033979599 scopus 로고    scopus 로고
    • Nephrotoxicity of immunosuppressive drugs: Long-term consequences and challenges for the future
    • Ojo AO, Held PJ, Port FK, et al. Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future. Am J Kidney Dis 2000; 35:333-346.
    • (2000) Am J Kidney Dis , vol.35 , pp. 333-346
    • Ojo, A.O.1    Held, P.J.2    Port, F.K.3
  • 27
    • 0344666767 scopus 로고    scopus 로고
    • The natural history of chronic allograft nephropathy
    • Nankivell BJ, Borrows RJ, Fung CL, et al. The natural history of chronic allograft nephropathy. N Engl J Med 2003; 349:2326-2333.
    • (2003) N Engl J Med , vol.349 , pp. 2326-2333
    • Nankivell, B.J.1    Borrows, R.J.2    Fung, C.L.3
  • 29
    • 0033610638 scopus 로고    scopus 로고
    • Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in Caucasian recipients of mismatched primary renal allografts: A phase II trial
    • Kahan BD, Julian BA, Pescovitz MD, et al. Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in Caucasian recipients of mismatched primary renal allografts: a phase II trial. Transplantation 1999; 68:1526-1532.
    • (1999) Transplantation , vol.68 , pp. 1526-1532
    • Kahan, B.D.1    Julian, B.A.2    Pescovitz, M.D.3
  • 30
    • 0035956745 scopus 로고    scopus 로고
    • A worldwide phase III randomised, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts
    • MacDonald AS. A worldwide phase III randomised, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts. Transplantation 2001; 71:271-280.
    • (2001) Transplantation , vol.71 , pp. 271-280
    • MacDonald, A.S.1
  • 31
    • 0035011155 scopus 로고    scopus 로고
    • Influence of cyclosporine, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation
    • Morales JM, Andres A, Rengel M, Rodicio JL. Influence of cyclosporine, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation. Nephrol Dial Transplant 2001; 16:121-124.
    • (2001) Nephrol Dial Transplant , vol.16 , pp. 121-124
    • Morales, J.M.1    Andres, A.2    Rengel, M.3    Rodicio, J.L.4
  • 32
    • 0035165578 scopus 로고    scopus 로고
    • Rapamycin in transplantation: A review of the evidence
    • Saunders RN, Metcalfe MS, Nicholson ML. Rapamycin in transplantation: a review of the evidence. Kidney Int 2001; 59:3-16.
    • (2001) Kidney Int , vol.59 , pp. 3-16
    • Saunders, R.N.1    Metcalfe, M.S.2    Nicholson, M.L.3
  • 33
    • 27644576791 scopus 로고    scopus 로고
    • Sirolimus in combination with tacrolimus is associated with worse renal allograft survival compared to mycophenolate mofetil combined with tacrolimus
    • Meier-Kriesche HU, Schold JD, Srinivas TR, et al. Sirolimus in combination with tacrolimus is associated with worse renal allograft survival compared to mycophenolate mofetil combined with tacrolimus. Am J Transplant 2005; 5:2273-2280.
    • (2005) Am J Transplant , vol.5 , pp. 2273-2280
    • Meier-Kriesche, H.U.1    Schold, J.D.2    Srinivas, T.R.3
  • 34
    • 0034667761 scopus 로고    scopus 로고
    • Rapamycin induces transforming growth factor-β production by lymphocytes
    • Dodge IL, Demirici G, Strom TB, Li XC. Rapamycin induces transforming growth factor-β production by lymphocytes. Transplantation 2000; 70:1104-1106.
    • (2000) Transplantation , vol.70 , pp. 1104-1106
    • Dodge, I.L.1    Demirici, G.2    Strom, T.B.3    Li, X.C.4
  • 35
    • 1642356729 scopus 로고    scopus 로고
    • Combination therapy with sirolimus and mycophenolate mofetil: Effects on the kidney and on transforming growth factor-β1
    • Shihab FS, Bennett WM, Hong Y, et al. Combination therapy with sirolimus and mycophenolate mofetil: effects on the kidney and on transforming growth factor-β1. Transplantation 2004; 77:683-686.
    • (2004) Transplantation , vol.77 , pp. 683-686
    • Shihab, F.S.1    Bennett, W.M.2    Hong, Y.3
  • 36
    • 0000961614 scopus 로고    scopus 로고
    • Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in nonhuman primates: Trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening
    • Ikonen TS, Gummert JF, Serkova N, et al. Efficacies of sirolimus (rapamycin) and cyclosporine in allograft vascular disease in nonhuman primates: trough levels of sirolimus correlate with inhibition of progression of arterial intimal thickening. Transpl Int 2000; 13 (Suppl 1):S314-S320.
    • (2000) Transpl Int , vol.13 , Issue.SUPPL. 1
    • Ikonen, T.S.1    Gummert, J.F.2    Serkova, N.3
  • 37
    • 0033979599 scopus 로고    scopus 로고
    • Nephrotoxicity of immunosuppressive drugs: Long-term consequences and challenges for the future
    • deMattaos AM, Olyai AJ, Bennett WM. Nephrotoxicity of immunosuppressive drugs: long-term consequences and challenges for the future. Am J Kidney Dis 2000; 35:333-346.
    • (2000) Am J Kidney Dis , vol.35 , pp. 333-346
    • deMattaos, A.M.1    Olyai, A.J.2    Bennett, W.M.3
  • 38
    • 4744351965 scopus 로고    scopus 로고
    • Effect of sirolimus withdrawal in patients with deteriorating renal function
    • Kaplan B, Schold J, Srinivas T, et al. Effect of sirolimus withdrawal in patients with deteriorating renal function. Am J Transplant 2004; 4:1709-1712.
    • (2004) Am J Transplant , vol.4 , pp. 1709-1712
    • Kaplan, B.1    Schold, J.2    Srinivas, T.3
  • 39
    • 33646372477 scopus 로고    scopus 로고
    • Improved renal function after conversion from tacrolimus/sirolimus to tacrolimus/mycophenolate mofetil in kidney transplant recipients
    • Augustine JJ, Chang PC, Knauss TC, et al. Improved renal function after conversion from tacrolimus/sirolimus to tacrolimus/mycophenolate mofetil in kidney transplant recipients. Transplantation 2006; 81:1004-1009.
    • (2006) Transplantation , vol.81 , pp. 1004-1009
    • Augustine, J.J.1    Chang, P.C.2    Knauss, T.C.3
  • 40
    • 33645945017 scopus 로고    scopus 로고
    • Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients
    • Stallone G, Infante B, Schena A, et al. Rapamycin for treatment of chronic allograft nephropathy in renal transplant patients. J Am Soc Nephrol 2005; 16:3755-3762.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3755-3762
    • Stallone, G.1    Infante, B.2    Schena, A.3
  • 41
    • 33747095113 scopus 로고    scopus 로고
    • Stephany BR, Augustine JJ, Krishnamurthi V, et al. Differences in proteinuria and graft function in de novo sirolimus-based versus calcineurin inhibitorbased immunosuppression in live donor kidney transplantation. Transplantation 2006; 82:368-374. This study is one of the first to suggest that sirolimus may cause proteinuria independent of treatment with calcineurin inhibitors.
    • Stephany BR, Augustine JJ, Krishnamurthi V, et al. Differences in proteinuria and graft function in de novo sirolimus-based versus calcineurin inhibitorbased immunosuppression in live donor kidney transplantation. Transplantation 2006; 82:368-374. This study is one of the first to suggest that sirolimus may cause proteinuria independent of treatment with calcineurin inhibitors.
  • 42
    • 34447501126 scopus 로고    scopus 로고
    • Oberbauer R, Schena FP, Wali R, et al. Conversion from caclineurin inhibitors to sirolimus compared with continued use of calcineurin inhibitors in renal allograft recipients: 24-month safety and efficacy results from the CONVERT trial [abstract]. J Am Soc Nephrol 2006; 17:69A. This abstract summarizes the important outcomes of the CONVERT trial, the largest currently active randomized trial of CNI-to-sirolimus conversion
    • Oberbauer R, Schena FP, Wali R, et al. Conversion from caclineurin inhibitors to sirolimus compared with continued use of calcineurin inhibitors in renal allograft recipients: 24-month safety and efficacy results from the CONVERT trial [abstract]. J Am Soc Nephrol 2006; 17:69A. This abstract summarizes the important outcomes of the CONVERT trial, the largest currently active randomized trial of CNI-to-sirolimus conversion
  • 43
    • 33750991068 scopus 로고    scopus 로고
    • Conversion from calcineurin inhibitors to sirolimus for chronic renal allograft dysfunction: A systematic review of the evidence
    • A meta-analysis of randomized and nonrandomized trials that forms the primary basis for the current review
    • Mulay AV, Cockfield S, Stryker R, et al. Conversion from calcineurin inhibitors to sirolimus for chronic renal allograft dysfunction: a systematic review of the evidence. Transplantation 2006; 82:1153-1162. A meta-analysis of randomized and nonrandomized trials that forms the primary basis for the current review.
    • (2006) Transplantation , vol.82 , pp. 1153-1162
    • Mulay, A.V.1    Cockfield, S.2    Stryker, R.3
  • 44
    • 33644694497 scopus 로고    scopus 로고
    • A randomized controlled trial of late conversion from CNI-based to sirolimus-based immunosuppression following renal transplantation
    • Watson CJE, Firth JE, Williams PF, et al. A randomized controlled trial of late conversion from CNI-based to sirolimus-based immunosuppression following renal transplantation. Am J Transplant 2005; 5:2496-2503.
    • (2005) Am J Transplant , vol.5 , pp. 2496-2503
    • Watson, C.J.E.1    Firth, J.E.2    Williams, P.F.3
  • 45
    • 33751016596 scopus 로고    scopus 로고
    • Six month interim analysis of a phase III prospective, randomised study to compare conversion from calcineurin inhibitors to rapamycin in established renal allograft recipients with mild to moderate renal insufficiency [abstract]
    • Baboolal K. Six month interim analysis of a phase III prospective, randomised study to compare conversion from calcineurin inhibitors to rapamycin in established renal allograft recipients with mild to moderate renal insufficiency [abstract]. Am J Transplant 2004; 4 (S8):220.
    • (2004) Am J Transplant , vol.4 , Issue.S8 , pp. 220
    • Baboolal, K.1
  • 46
    • 28444436796 scopus 로고    scopus 로고
    • An open non comparative pilot study of renal function after conversion from cyclosporine to sirolimus in stable renal allograft recipients with mild to moderate renal insufficiency [abstract]
    • Paczek L, Dedocova J, Matl I, Ohanka E. An open non comparative pilot study of renal function after conversion from cyclosporine to sirolimus in stable renal allograft recipients with mild to moderate renal insufficiency [abstract]. Am J Transplant 2003; 3 (Suppl 5):217.
    • (2003) Am J Transplant , vol.3 , Issue.SUPPL. 5 , pp. 217
    • Paczek, L.1    Dedocova, J.2    Matl, I.3    Ohanka, E.4
  • 47
    • 13644265974 scopus 로고    scopus 로고
    • An open-label pilot study evaluating the safety and efficacy of converting from calcineurin inhibitors to sirolimus in established renal allograft recipients with moderate renal insufficiency
    • Peddi VR, Jensik S, Pescovitz M, et al. An open-label pilot study evaluating the safety and efficacy of converting from calcineurin inhibitors to sirolimus in established renal allograft recipients with moderate renal insufficiency. Clin Transplant 2005; 19:130-136.
    • (2005) Clin Transplant , vol.19 , pp. 130-136
    • Peddi, V.R.1    Jensik, S.2    Pescovitz, M.3
  • 48
    • 28444491603 scopus 로고    scopus 로고
    • Can we change the progressive decay in graft function after the onset of chronic allograft nephropathy in the recipients of kidney allografts? [abstract]
    • Wali RK, Richards A, Cunningham R, et al. Can we change the progressive decay in graft function after the onset of chronic allograft nephropathy in the recipients of kidney allografts? [abstract]. Am J Transplant 2003; 3 (S5):336.
    • (2003) Am J Transplant , vol.3 , Issue.S5 , pp. 336
    • Wali, R.K.1    Richards, A.2    Cunningham, R.3
  • 49
    • 33750971395 scopus 로고    scopus 로고
    • Conversion to and from sirolimus in renal and hepatic transplant recipients treated with calcineurin inhibitors: Effect on renal function [abstract]
    • Moneim HA, Fletchner SM, George P, et al. Conversion to and from sirolimus in renal and hepatic transplant recipients treated with calcineurin inhibitors: effect on renal function [abstract]. Am J Transplant 2005; 5 (S11):376.
    • (2005) Am J Transplant , vol.5 , Issue.S11 , pp. 376
    • Moneim, H.A.1    Fletchner, S.M.2    George, P.3
  • 50
    • 27644485782 scopus 로고    scopus 로고
    • Switch of immunosuppression from calci9neurin inhibitors to sirolimus in pediatric renal transplant recipients with CNI toxicity [abstract]
    • Hoecker N, Feneberg R, Koepf S, et al. Switch of immunosuppression from calci9neurin inhibitors to sirolimus in pediatric renal transplant recipients with CNI toxicity [abstract]. Am J Transplant 2005; 5 (S11):497.
    • (2005) Am J Transplant , vol.5 , Issue.S11 , pp. 497
    • Hoecker, N.1    Feneberg, R.2    Koepf, S.3
  • 51
    • 27644439969 scopus 로고    scopus 로고
    • Lonf term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimus
    • Bumbea V, Kamar N, Ribes D, et al. Lonf term results in renal transplant patients with allograft dysfunction after switching from calcineurin inhibitors to sirolimus. Nephrol Dial Transplant 2005; 20:2517-2523.
    • (2005) Nephrol Dial Transplant , vol.20 , pp. 2517-2523
    • Bumbea, V.1    Kamar, N.2    Ribes, D.3
  • 52
    • 28444499887 scopus 로고    scopus 로고
    • A single center experience with sirolimus conversion therapy in renal allograft recipients [abstract]
    • Crowley KL, Hardinger KL, Koch M, et al. A single center experience with sirolimus conversion therapy in renal allograft recipients [abstract]. Am J Transplant 2003; 3 (S5):354.
    • (2003) Am J Transplant , vol.3 , Issue.S5 , pp. 354
    • Crowley, K.L.1    Hardinger, K.L.2    Koch, M.3
  • 53
    • 0035674916 scopus 로고    scopus 로고
    • Conversion to rapamycin in renal allograft recipients with biopsy-proven calcineurin inhibitor induced nephrotoxicity
    • Diekmann F, Waiser J, Fritsche L, et al. Conversion to rapamycin in renal allograft recipients with biopsy-proven calcineurin inhibitor induced nephrotoxicity. Transplant Proc 2001; 33:3234-3235.
    • (2001) Transplant Proc , vol.33 , pp. 3234-3235
    • Diekmann, F.1    Waiser, J.2    Fritsche, L.3
  • 54
    • 0038298952 scopus 로고    scopus 로고
    • Conversion to sirolimus in solid organ transplantation: A single-center experience
    • Egidi MF, Cowan PA, Naser A, Gaber AO. Conversion to sirolimus in solid organ transplantation: a single-center experience. Transplant Proc 2003; 35:131S-137S.
    • (2003) Transplant Proc , vol.35
    • Egidi, M.F.1    Cowan, P.A.2    Naser, A.3    Gaber, A.O.4
  • 55
    • 33750968731 scopus 로고    scopus 로고
    • Nephrotic range proteinuria and other severe adverse events after conversion to sirolimus in renal transplantation: Is high exposure to sirolimus responsible? [abstract]
    • Hadaya K, Wissing M, Broeders N, Abramaowicz D. Nephrotic range proteinuria and other severe adverse events after conversion to sirolimus in renal transplantation: is high exposure to sirolimus responsible? [abstract]. Am J Transplant 2004; 4 (S8):433.
    • (2004) Am J Transplant , vol.4 , Issue.S8 , pp. 433
    • Hadaya, K.1    Wissing, M.2    Broeders, N.3    Abramaowicz, D.4
  • 56
    • 33750969312 scopus 로고    scopus 로고
    • Sirolimus associated proteinuria. Study in kidney and heart recipients after calcineurin inhibitor withdrawal and in kidney transplant recipients with sirolimus de novo immunosuppression. [abstract]
    • Lacha J, Bartosova K, Matl I, et al. Sirolimus associated proteinuria. Study in kidney and heart recipients after calcineurin inhibitor withdrawal and in kidney transplant recipients with sirolimus de novo immunosuppression. [abstract]. Am J Transplant 2005; 5:414.
    • (2005) Am J Transplant , vol.5 , pp. 414
    • Lacha, J.1    Bartosova, K.2    Matl, I.3
  • 57
    • 4344686731 scopus 로고    scopus 로고
    • Low-dose sirolimus in combination with mycophenolate mofetil improves kidney graft function late after renal transplantation and suggests pharmacokinetic interaction of both immunosuppressive drugs
    • Renders L, Steinbach R, Valerius T, et al. Low-dose sirolimus in combination with mycophenolate mofetil improves kidney graft function late after renal transplantation and suggests pharmacokinetic interaction of both immunosuppressive drugs. Kidney Blood Press 2004; 27:181-185.
    • (2004) Kidney Blood Press , vol.27 , pp. 181-185
    • Renders, L.1    Steinbach, R.2    Valerius, T.3
  • 58
    • 0037783795 scopus 로고    scopus 로고
    • Rapid conversion to sirolimus for chronic progressive deterioration of the renal function in kidney allograft recipients
    • Citterlo F, Scata MC, Violo P, et al. Rapid conversion to sirolimus for chronic progressive deterioration of the renal function in kidney allograft recipients. Transplant Proc 2003; 35:1292-1294.
    • (2003) Transplant Proc , vol.35 , pp. 1292-1294
    • Citterlo, F.1    Scata, M.C.2    Violo, P.3
  • 59
    • 32844474879 scopus 로고    scopus 로고
    • Glucose metabolism in renal transplant recipients: Effect of calcineurin inhibitor withdrawal and conversion to sirolimus
    • Teutonico A, Schena PF, Paolo S. Glucose metabolism in renal transplant recipients: effect of calcineurin inhibitor withdrawal and conversion to sirolimus. J Am Soc Nephrol 2005; 16:3128-3135.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3128-3135
    • Teutonico, A.1    Schena, P.F.2    Paolo, S.3
  • 60
    • 0345118182 scopus 로고    scopus 로고
    • Oral ulcers in kidney transplant recipients treated with sirolimus and mycophenolate mofetil
    • Van Gelder T, ter Muelen CG, Hene R, et al. Oral ulcers in kidney transplant recipients treated with sirolimus and mycophenolate mofetil. Transplantation 2003; 75:788-792.
    • (2003) Transplantation , vol.75 , pp. 788-792
    • Van Gelder, T.1    ter Muelen, C.G.2    Hene, R.3


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